Search Results - "Swamynayaka, Ananda"
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Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells
Published in Molecules (Basel, Switzerland) (01-04-2023)“…Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a…”
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Development of 1-(4-(Substituted)piperazin-1-yl)-2-((2-((4-methoxybenzyl)thio)pyrimidin-4-yl)oxy)ethanones That Target Poly (ADP-Ribose) Polymerase in Human Breast Cancer Cells
Published in Molecules (Basel, Switzerland) (29-04-2022)“…A number of uracil amides cleave poly (ADP-ribose) polymerase and therefore novel thiouracil amide compounds were synthesized and screened for the loss of cell…”
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Investigation of NPB Analogs That Target Phosphorylation of BAD-Ser99 in Human Mammary Carcinoma Cells
Published in International journal of molecular sciences (12-10-2021)“…The design and development of a small molecule named NPB [3-{(4(2,3-dichlorophenyl)piperazin-1-yl}{2-hydroxyphenyl)methyl}-N-cyclopentylbenzamide], which…”
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Oxazine drug-seed induces paraptosis and apoptosis through reactive oxygen species/JNK pathway in human breast cancer cells
Published in Translational oncology (01-11-2024)“…•To overcome drug-resistant breast cancer, it is essential to develop compounds that induce apoptosis and paraptosis.•BSO-07 triggered G1 phase arrest, cleaved…”
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Methyl-Thiol-Bridged Oxadiazole and Triazole Heterocycles as Inhibitors of NF-κB in Chronic Myelogenous Leukemia Cells
Published in Biomedicines (01-06-2023)“…Nuclear factor kappa beta (NF-κB) is a transcriptional factor that plays a crucial role in regulating cancer cell proliferation. Therefore, the inhibition of…”
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Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromo-phen-yl)imidazo[1,2- a ]pyridine
Published in Acta crystallographica. Section E, Crystallographic communications (01-11-2019)“…The title imidazo[1,2- ] pyridine derivative, C H Br N , was synthesized a single-step reaction method. The title mol-ecule is planar, showing a dihedral angle…”
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De Novo Design of Imidazopyridine-Tethered Pyrazolines That Target Phosphorylation of STAT3 in Human Breast Cancer Cells
Published in Bioengineering (Basel) (24-01-2023)“…In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for…”
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Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells
Published in Biomedicines (10-01-2023)“…Small molecules are being used to inhibit cyclin dependent kinase (CDK) enzymes in cancer treatment. There is evidence that CDK is a drug-target for cancer…”
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Third-order nonlinear response of a novel organic acetohydrazide derivative: Experimental and theoretical approach
Published in Optical materials (01-05-2023)“…A novel nonlinear optical (NLO) organic material of N'-[(E)-(5-bromofuran-2-yl)methylidene]-2-(6-chloropyridin-3-yl)acetohydrazide (BCA) was synthesized by…”
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Physicochemical properties of thiazole-based NLO crystal: An efficient material for optoelectronic applications
Published in Journal of molecular structure (05-01-2025)“…•Good quality BTC single crystals were grown by slow evaporation solution method.•The PL study revealed a sharp, high-intensity peak at 420 nm, indicating its…”
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Optical limiting and third-order nonlinear optical properties of thiazole-based chalcone derivative: Insights from experimental and theoretical approaches
Published in Optical materials (01-11-2024)“…The current study delves into exploring the linear and nonlinear optical properties of (E)-3-(4-methylthiazole-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one (MNP)…”
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A simple fluorescent “Turn-Off” Schiff base sensor for Cu2+ and Fe2+ ions and its applications in real water sample analysis and logic gate construction
Published in Polyhedron (15-09-2024)“…[Display omitted] •Synthesized imidazole-based Schiff base ligand (Z)-N’-((1H-imidazol-2-yl)methylene)-2-hydroxybenzohydrazide (IMBH).•IMBH was used as a…”
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Third-order nonlinear optical studies of Bis(4-methylbenzylammonium) tetrachloridocuprate metal-organic crystal with optical limiting behavior: Experimental and theoretical investigations
Published in Journal of molecular structure (05-12-2022)“…•NLO single crystal of Bis(4-methylbenzylammonium) tetrachloridocuprate (4MBA) has been successfully grown by slow evaporation solution growth technique.•4MBA…”
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Chalcone-based Turn-Off Chemosensor for Selective and Susceptible Detection of Fe2+ Ions: Spectroscopic and DFT Investigations
Published in Journal of fluorescence (08-03-2024)“…Herein, in this report we are introducing newly synthesized chalcone derivative,…”
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Chalcone-based Turn-Off Chemosensor for Selective and Susceptible Detection of Fe 2+ Ions: Spectroscopic and DFT Investigations
Published in Journal of fluorescence (08-03-2024)“…Herein, in this report we are introducing newly synthesized chalcone derivative,…”
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Molecular Structure, DFT, Vibrational Spectra with Fluorescence Effect, Hirshfeld Surface, Docking Simulation and Antioxidant Activity of Thiazole Derivative
Published in ChemistrySelect (Weinheim) (24-04-2019)“…2‐(4‐methylphenoxy)‐N‐(4‐(4‐bromophenyl) thiazol‐2‐yl) acetamide compound was obtained via a multistep synthesis sequence processes, which is characterized by…”
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Crystal structure, DFT calculation, Hirshfeld surface analysis and energy framework study of 6-bromo-2-(4-bromo-phen-yl)imidazo1,2-apyridine
Published in Acta crystallographica. Section E, Crystallographic communications (01-11-2019)“…The title imidazo[1,2-a] pyridine derivative, C13H8Br2N2, was synthesized via a single-step reaction method. The title mol-ecule is planar, showing a dihedral…”
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