Search Results - "Swamy, Malisetty V"

Diosgenin, a Steroid Saponin of Trigonella foenum graecum (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells by RAJU, Jayadev, PATLOLLA, Jagan M. R, SWAMY, Malisetty V, RAO, Chinthalapally V

“…Trigonella foenum graecum (fenugreek) is traditionally used to treat disorders such as diabetes, high cholesterol, wounds, inflammation, and gastrointestinal…”
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Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice by SWAMY, Malisetty V, PATLOLLA, Jagan M. R, STEELE, Vernon E, KOPELOVICH, Levy, REDDY, Bandaru S, RAO, Chinthalapally V

“…Preclinical and clinical studies have established evidence that cyclooxygenase-2 (COX-2) inhibitors and statins [hydroxy-3-methylglutaryl CoA reductase (HMGR)…”
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Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells by Patlolla, Jagan M R, Raju, Jayadev, Swamy, Malisetty V, Rao, Chinthalapally V

“…Extracts of Aesculus hippocastanum (horse chestnut) seed have been used in the treatment of chronic venous insufficiency, edema, and hemorrhoids. Most of the…”
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Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids by Swamy, Malisetty V, Citineni, Bhargava, Patlolla, Jagan M.R, Mohammed, Altaf, Zhang, Yuting, Rao, Chinthalapally V

“…Pancreatic cancer BxPC-3 cells were exposed to curcumin, docosahexaenoic acid (DHA), or combinations of both and analyzed for proliferation and apoptosis…”
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Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells by Janakiram, Naveena B., Indranie, Cooma, Malisetty, Swamy V., Jagan, Patlolla, Steele, Vernon E., Rao, Chinthalapally V.

“…Purpose To assess the chemopreventive effect of oleanolic acid (ONA) and its synthetic analog 18α-olean-12-ene-3β-23,28-triol (OT) on azoxymethane…”
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Colonic Tumorigenesis in BubR1+/-ApcMin/+Compound Mutant Mice Is Linked to Premature Separation of Sister Chromatids and Enhanced Genomic Instability by Rao, Chinthalapally V., Yang-Ming Yang, Swamy, Malisetty V., Liu, Tongyi, Fang, Yuqiang, Mahmood, Radma, Jhanwar-Uniyal, Meena, Dai, Wei, Vogelstein, Bert

“…Faithful chromosome segregation is essential for the maintenance of genetic stability during cell division and it is at least partly monitored by the spindle…”
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Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53 by SWAMY, Malisetty V, HERZOG, Christopher R, RAO, Chinthalapally V

“…Inactivation of the p53 tumor suppressor gene usually involves somatic mutation or binding of viral oncoproteins to the p53 protein. However, several types of…”
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Inhibition of Azoxymethane-Induced Colorectal Cancer by CP-31398, a TP53 Modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats by RAO, Chinthalapally V, STEELE, Vernon E, SWAMY, Malisetty V, PATLOLLA, Jagan M. R, GURUSWAMY, Suresh, KOPELOVICH, Levy

“…Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53-modulating agent CP-31398 alone and…”
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S‐adenosyl L‐methionine inhibits azoxymethane‐induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco‐2 cell growth in 3D culture by Guruswamy, Suresh, Swamy, Malisetty V., Choi, Chang‐In, Steele, Vernon E., Rao, Chinthalapally V.

“…S‐Adenosyl L‐methionine (SAM) is a universal methyl group donor to various intermediary metabolites, hormones, proteins, neurotransmitters, phospholipids and…”
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Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment by Swamy, Malisetty V, Cooma, Indranie, Patlolla, Jagan M R, Simi, Barbara, Reddy, Bandaru S, Rao, Chinthalapally V

“…To develop efficient synergistic or additive combinations of chemopreventive and nutritional agents to reduce the risk of colon cancer, experiments were…”
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Suppression of familial adenomatous polyposis by CP-31398, a TP53 modulator, in APCmin/+ mice by Rao, Chinthalapally V, Swamy, Malisetty V, Patlolla, Jagan M R, Kopelovich, Levy

“…p53 mutations occur in a large number of human malignancies. Mutant p53 is unable to affect downstream genes necessary for DNA repair, cell cycle regulation,…”
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Low doses of β‐carotene and lutein inhibit AOM‐induced rat colonic ACF formation but high doses augment ACF incidence by Raju, Jayadev, Swamy, Malisetty V., Cooma, Indranie, Patlolla, Jagan M.R., Pittman, Brian, Reddy, Bandaru S., Steele, Vernon E., Rao, Chinthalapally V.

“…Epidemiological studies suggest that carotenoids such as β‐carotene and lutein play an important role in reducing the risk for several cancers. However, in…”
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Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens by Swamy, Malisetty V, Cooma, Indranie, Reddy, Bandaru S, Rao, Chinthalapally V

“…Apoptosis plays a central role in tumor development and it has been hypothesized that lack/failure of apoptosis leads to the development of tumors, including…”
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Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines by Patlolla, Jagan M R, Swamy, Malisetty V, Raju, Jayadev, Rao, Chinthalapally V

“…Caveolin-1, -2, and -3 are the principal proteins of caveolae, the vesicular invaginations of the plasma membrane. Recent studies suggest that caveolins play…”
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Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation by El-Bayoumy, Karam, Rose, David P, Papanikolaou, Nick, Leszczynska, Joanna, Swamy, Malisetty V, Rao, Chinthalapally V

“…Increased expression of cyclooxygenase-2 (COX-2) significantly enhances carcinogenesis and inflammatory reactions. Regulation of COX-2 overexpression may be a…”
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Abstract 954: A selective iNOS inhibitor N6-iminoethyl-lysine tetrazoleamide (NILT), suppress invasive colonic cancers and improves preventive efficacy of low-dose COX-2 inhibitor, celecoxib in F344 rats by Janakiram, Naveena B., Swamy, Malisetty V., Patlolla, Jagan M., Guruswamy, Suresh, Rao, Chinthalapally V.

“…Abstract Clinical and preclinical studies suggest that NSAIDs and cyclooxygenase (COX)-2 inhibitors such as celecoxib, reduce the risk of colorectal cancer…”
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Inhibition of AOM-Induced Colorectal Cancer by CP-31398, a TP53 modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats by Rao, Chinthalapally V., Steele, Vernon E., Swamy, Malisetty V., Patlolla, Jagan M.R., Guruswamy, Suresh, Kopelovich, Levy

“…Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53 modulating agent CP-31398 alone and…”
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Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 modulator, in APCmin/+ Mice1 by Rao, Chinthalapally V., Swamy, Malisetty V., Patlolla, Jagan M.R., Kopelovich, Levy

“…p53 mutations occur in a large number of human malignancies. Mutant p53 is unable to affect downstream genes necessary for DNA repair, cell cycle regulation,…”
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Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in APC7min/+ Mice by RAO, Chinthalapally V, SWAMY, Malisetty V, PATLOLLA, Jagan M. R, KOPELOVICH, Levy

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Chemoprevention of Colon Carcinogenesis by Oleanolic Acid and Its Analog in Male F344 Rats and Modulation of COX-2 and Apoptosis in Human Colon HT-29 Cancer Cells : Cancer chemoprevention by JANAKIRAM, Naveena B, INDRANIE, Cooma, MALISETTY, Swamy V, JAGAN, Patlolla, STEELE, Vernon E, RAO, Chinthalapally V

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