Search Results - "Swales, K. E."

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man by Gibson, G. G., Plant, N. J., Swales, K. E., Ayrton, A., El-Sankary, W.

“…1 The importance of CYP3A enzymes in drug metabolism and toxicology has yielded a wealth of information on the structure, function and regulation of this…”
Get full text

A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia by Vormoor, B., Veal, G. J., Griffin, M. J., Boddy, A. V., Irving, J., Minto, L., Case, M., Banerji, U., Swales, K. E., Tall, J. R., Moore, A. S., Toguchi, M., Acton, G., Dyer, K., Schwab, C., Harrison, C. J., Grainger, J. D., Lancaster, D., Kearns, P., Hargrave, D., Vormoor, J.

“…Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify…”
Get full text

Purinergic 2X1 receptors mediate endothelial dependent vasodilation to ATP by Harrington, L S, Evans, R J, Wray, J, Norling, L, Swales, K E, Vial, C, Ali, F, Carrier, M J, Mitchell, J A

“…ATP is an important endogenous mediator in the cardiovascular system. It induces endothelium dependent vasodilation, but the precise receptor pathway activated…”
Get more information

A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer by Kolinsky, M.P., Rescigno, P., Bianchini, D., Zafeiriou, Z., Mehra, N., Mateo, J., Michalarea, V., Riisnaes, R., Crespo, M., Figueiredo, I., Miranda, S., Nava Rodrigues, D., Flohr, P., Tunariu, N., Banerji, U., Ruddle, R., Sharp, A., Welti, J., Lambros, M., Carreira, S., Raynaud, F.I., Swales, K.E., Plymate, S., Luo, J., Tovey, H., Porta, N., Slade, R., Leonard, L., Hall, E., de Bono, J.S.

“…Activation of the PI3K/AKT/mTOR pathway through loss of phosphatase and tensin homolog (PTEN) occurs in approximately 50% of patients with metastatic…”
Get full text

Follicular growth and oocyte competence in the in vitro cultured mouse follicle: effects of gonadotrophins and steroids by Murray, Alison A., Swales, Anna K.E., Smith, Rowena E., Molinek, Michael D., Hillier, Stephen G., Spears, Norah

“…Although there have been extensive studies on the effects of gonadotrophins and steroids on follicular development, less is known as to the effects these…”
Get full text

Genomic imprinting and reproduction by Swales, A K E, Spears, N

“…Genomic imprinting is the parent-of-origin specific gene expression which is a vital mechanism through both development and adult life. One of the key elements…”
Get full text

Soluble HLA-G in IVF/ICSI embryo culture supernatants does not always predict implantation success: a multicentre study by Tabiasco, Julie, d'Hauterive, Sophie Perrier, Thonon, Fabienne, Parinaud, Jean, Léandri, Roger, Foidart, Jean-Michel, Chaouat, Gérard, Munaut, Carine, Lombroso, Raoul, Selva, Jacqueline, Bergère, Marianne, Hammoud, Ibrahim, Kozma, Noemi, Aguerre-Girr, Maryse, Swales, Anna KE, Sargent, Ian L, Le Bouteiller, Philippe, Lédée, Nathalie

“…Abstract Several reports have described an association between the presence of soluble human leukocyte antigen G (sHLA-G) in human embryo culture supernatants…”
Get full text

Use of suppression-PCR subtractive hybridisation to identify genes that demonstrate altered expression in male rat and guinea pig livers following exposure to Wy-14,643, a peroxisome proliferator and non-genotoxic hepatocarcinogen by Rockett, John C, Swales, Karen E, Esdaile, David J, Gibson, G.Gordon

“…Understanding the genetic profile of a cell at all stages of normal and carcinogenic development should provide an essential aid to developing new strategies…”
Get full text