Search Results - "Swales, Catherine"

Angiopoietin-like 4 is over-expressed in rheumatoid arthritis patients: association with pathological bone resorption by Swales, Catherine, Athanasou, Nicholas A, Knowles, Helen J

“…Osteoclasts are responsible for the bone loss associated with rheumatoid arthritis (RA). The secreted adipokine angiopoietin-like 4 (ANGPTL4) specifically…”
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Cross-sectional Survey of Medical student Attitudes to Research and Training pathways (SMART) in the UK: study protocol by Roche, Sophie, Bandyopadhyay, Soham, Grassam-Rowe, Alexander, Brown, Robin Andrew, Iveson, Poppy, Mallett, Garry, Eggington, Holly, Swales, Catherine

“…BackgroundAn understanding and appreciation of scientific research is a key quality of the modern clinician. Yet the Medical Schools Council has previously…”
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Cross-sectional Survey of Medical student perceptions of And desires for Research and Training pathways (SMART): an analysis of prospective cohort study of UK medical students by Parameswaran, Gokul, Bowman, Amelia, Swales, Catherine, Ooi, Setthasorn Zhi Yang, Chan, Shie Wei, Babu, Priya Rose, Ramsay, Daniele, Kostoudi, Sofia, Bandyopadhyay, Soham

“…Clinician-scientists are critical to medical innovation and research. However, the number of clinician scientists in the UK has been declining steadily over…”
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Synovial fluid fingerprinting in end-stage knee osteoarthritis: a novel biomarker concept by Jayadev, Chethan, Hulley, Philippa, Swales, Catherine, Snelling, Sarah, Collins, Gary, Taylor, Peter, Price, Andrew

“…The lack of disease-modifying treatments for osteoarthritis (OA) is linked to a shortage of suitable biomarkers. This study combines multi-molecule synovial…”
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Cellular and molecular mechanisms of bone damage and repair in inflammatory arthritis by Swales, Catherine, Sabokbar, Afsie

“…•An increased RANKL:OPG ratio favours osteoclastogenesis and bone resorption.•TH17 cells (and IL-17) are crucial regulators of osteoclast activity.•IL-23 is…”
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Anti-tumour necrosis factor therapy in seronegative spondyloarthritis by Swales, Catherine, Bowness, Paul

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Are Janus kinase inhibitors safe and effective in treating the key clinical domains of psoriatic arthritis? A systematic review and meta‐analysis by Harkins, Patricia, Burke, Eoghan, Swales, Catherine, Silman, Alan, Conway, Richard

“…Objectives Psoriatic arthritis (PsA), is a complex inflammatory arthropathy with a heterogenous spectrum of disease presentation. Despite the vast therapeutic…”
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420 ‘Weigh to go’ report of the British academy of childhood disability (BACD) national audit by Lau, Witney, Swales, Catherine, Lazenby, Sophia, Tuffrey, Catherine, Robinson, Kelly, Cadwgan, Jill

“…ObjectiveThe BACD launched the WEIGH TO GO! Initiative in November 2022.The aim of this national re-audit (five years post NCEPOD report), is to assess growth…”
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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response by Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K., Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J., Sheppard, Robert J., Smith, Julia E., Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J., Lee, Kevin, Wilson, David M.

“…A structure-guided small-molecule and chemoproteomics approach uncovers a catalytic site inhibitor selective for the jumonji subfamily of H3K27me3…”
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The online version of an evidence-based hand exercise program for people with rheumatoid arthritis: A mixed-method, proof-of-concept study by Srikesavan, Cynthia, Williamson, Esther, Thompson, Jacqueline Y., Cranston, Tim, Swales, Catherine, Lamb, Sarah E.

“…The Strengthening And stretching for Rheumatoid Arthritis of the Hand (SARAH) program is a tailored, 12-week hand and arm exercise program recommended in the…”
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Virtual patients improve history-taking competence and confidence in medical students by Raafat, Nader, Harbourne, Alexander D, Radia, Kajal, Woodman, Myles J, Swales, Catherine, Saunders, Kate E A

“…Klark is a novel online medical education tool (www.klark-cases.com) where students take histories from virtual patients with common presentations from…”
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‘All disease begins in the gut’—the role of the intestinal microbiome in ankylosing spondylitis by Harkins, Patricia, Burke, Eoghan, Swales, Catherine, Silman, Alan

“…Ankylosing spondylitis is a chronic, debilitating arthritis with a predilection for the axial skeleton. It has a strong genetic predisposition, but the precise…”
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Thoughts of being an imposter, in medical students by Warraich, Sara, Swales, Catherine, O'Leary, Denis

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The impact of patient skin colour on diagnostic ability and confidence of medical students by Dodd, Rebecca V., Rafi, Damir, Stackhouse, Ashlyn A., Brown, Celia A., Westacott, Rachel J., Meeran, Karim, Hughes, Elizabeth, Wilkinson, Paul, Gurnell, Mark, Swales, Catherine, Sam, Amir H.

“…Previous literature has explored unconscious racial biases in clinical education and medicine, finding that people with darker skin tones can be…”
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TSG‐6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin by Mahoney, David J., Swales, Catherine, Athanasou, Nicholas A., Bombardieri, Michele, Pitzalis, Costantino, Kliskey, Karolina, Sharif, Mohammed, Day, Anthony J., Milner, Caroline M., Sabokbar, Afsie

“…Objective TSG‐6 (the product of tumor necrosis factor [TNF]–stimulated gene 6) has a potent inhibitory effect on RANKL‐mediated bone erosion. The aim of this…”
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131. Utility of Ultrasound in the Nuffield Orthopaedic Centre Emergency Rheumatology Clinic: Survey of Clinical Effectiveness by Bhamra, Kuljeet K., Seymour, Matthew W., Swales, Catherine E., Taylor, Peter C.

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Independent roles for the dorsal paraflocculus and vermal lobule VII of the cerebellum in visuomotor coordination by KRALJ-HANS, Ines, BAIZER, Joan S, SWALES, Catherine, GLICKSTEIN, Mitchell

“…Two distinct areas of cerebellar cortex, vermal lobule VII and the dorsal paraflocculus (DPFl) receive visual input. To help understand the visuomotor…”
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Kruidenier et al. reply by Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K., Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J., Sheppard, Robert J., Smith, Julia E., Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J., Lee, Kevin, Wilson, David M.

“…Replying to B. Heinemann et al. Nature514, 10.1038/nature13688 (2014) We welcome the accompanying Comment 1 by Heinemann et al. , in which the authors use an…”
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Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis by Sabokbar, Afsie, Afrough, Sara, Mahoney, David J, Uchihara, Yoshinobu, Swales, Catherine, Athanasou, Nicholas A

“…To characterise the role of substitutes for receptor-activator nuclear factor kappa-B ligand (RANKL) in rheumatoid arthritis (RA) joint destruction. Synovial…”
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Inhibition of demethylases by GSK-J1/J4/Kruidenier et al. reply by Heinemann, Bo, Nielsen, Jesper Morten, Hudlebusch, Heidi Rye, Lees, Michael J, Larsen, Dorthe Vang, Boesen, Thomas, Labelle, Marc, Gerlach, Lars-Ole, Birk, Peter, Helin, Kristian, Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K, Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J, Sheppard, Robert J, Smith, Julia E, Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J, Lee, Kevin, Wilson, David M

“…Here we show that the inhibitor is not specific for the H3K27me3/me2-demethylase subfamily in vitro and in tissue culture assays. Thus, the inhibitor cannot be…”
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