Search Results - "Swain, Mark G"

Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression by D'Mello, Charlotte, Swain, Mark G

“…A growing body of evidence now highlights a key role for inflammation in mediating sickness behaviors and depression. Systemic inflammatory diseases such as…”
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Liver–brain interactions in inflammatory liver diseases: Implications for fatigue and mood disorders by D’Mello, Charlotte, Swain, Mark G

“…Highlight • Communication between liver and the brain via neural, humoral and monocyte-driven pathways mediates alterations in central neural activity and…”
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Fatigue in chronic liver disease: New insights and therapeutic approaches by Swain, Mark G., Jones, David E. J.

“…The management of fatigue associated with chronic liver disease is a complex and major clinical challenge. Although fatigue can complicate many chronic…”
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Modelling the cost effectiveness of non-alcoholic fatty liver disease risk stratification strategies in the community setting by Congly, Stephen E, Shaheen, Abdel Aziz, Swain, Mark G

“…Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. Identifying high-risk patients is critical to best utilize limited health…”
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Liver-brain inflammation axis by D'Mello, Charlotte, Swain, Mark G

“…It is becoming increasingly evident that peripheral organ-centered inflammatory diseases, including chronic inflammatory liver diseases, are associated with…”
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Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms by Nguyen, Henry H, Swain, Mark G

“…Symptoms of fatigue, social withdrawal and mood disturbances are commonly encountered in patients with chronic liver disease and have a detrimental effect on…”
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Race and Ethnicity in Non-Alcoholic Fatty Liver Disease (NAFLD): A Narrative Review by Riazi, Kiarash, Swain, Mark G, Congly, Stephen E, Kaplan, Gilaad G, Shaheen, Abdel-Aziz

“…Non-alcoholic fatty liver disease (NAFLD) is a significant public health concern worldwide with a complex etiology attributed to behavioural, environmental,…”
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Liver stiffness by transient elastography predicts liver-related complications and mortality in patients with chronic liver disease by Pang, Jack X Q, Zimmer, Scott, Niu, Sophia, Crotty, Pam, Tracey, Jenna, Pradhan, Faruq, Shaheen, Abdel Aziz M, Coffin, Carla S, Heitman, Steven J, Kaplan, Gilaad G, Swain, Mark G, Myers, Robert P

“…Liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) is a validated method for noninvasively staging liver fibrosis. Most hepatic…”
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Hepatic NKT cells: friend or foe? by Swain, Mark G

“…The innate immune system represents a critical first line of host response to infectious, injurious and inflammatory insults. NKT cells (natural killer…”
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The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice by Almishri, Wagdi, Shaheen, Abdel Aziz, Sharkey, Keith A, Swain, Mark G

“…Activation of the innate immune system, including tissue macrophages and associated neutrophil infiltration, is an important driver of subsequent adaptive…”
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The burden of hepatitis B virus (HBV) infection, genotypes and drug resistance mutations in human immunodeficiency virus-positive patients in Northwest Ethiopia by Deressa, Tekalign, Damtie, Debasu, Fonseca, Kevin, Gao, Shan, Abate, Ebba, Alemu, Shitaye, Aleka, Yetemwork, Swain, Mark G, van Marle, Guido, Coffin, Carla S

“…In sub-Saharan Africa, the hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections are endemic. Although there has been great progress in HIV…”
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Evaluation of classical and novel autoantibodies for the diagnosis of Primary Biliary Cholangitis-Autoimmune Hepatitis Overlap Syndrome (PBC-AIH OS) by Nguyen, Henry H, Shaheen, Abdel Aziz, Baeza, Natalia, Lytvyak, Ellina, Urbanski, Stefan J, Mason, Andrew L, Norman, Gary L, Fritzler, Marvin J, Swain, Mark G

“…Up to 20% of Primary Biliary Cholangitis (PBC) patients are estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH…”
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P-selectin-mediated monocyte-cerebral endothelium adhesive interactions link peripheral organ inflammation to sickness behaviors by D'Mello, Charlotte, Riazi, Kiarash, Le, Tai, Stevens, Katarzyna M, Wang, Arthur, McKay, Derek M, Pittman, Quentin J, Swain, Mark G

“…Sickness behaviors, such as fatigue, mood alterations, and cognitive dysfunction, which result from changes in central neurotransmission, are prevalent in…”
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Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior by Cluny, Nina L, Nyuyki, Kewir D, Almishri, Wagdi, Griffin, Lateece, Lee, Benjamin H, Hirota, Simon A, Pittman, Quentin J, Swain, Mark G, Sharkey, Keith A

“…Behavioral comorbidities, such as anxiety and depression, are a prominent feature of IBD. The signals from the inflamed gut that cause changes in the brain…”
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Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences by Nyuyki, Kewir D, Cluny, Nina L, Swain, Mark G, Sharkey, Keith A, Pittman, Quentin J

“…Crohn's disease (CD) and ulcerative colitis (UC) are incurable lifelong inflammatory bowel diseases (IBD) with a rising worldwide incidence. IBD is…”
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The impact of depression and antidepressant usage on primary biliary cholangitis clinical outcomes by Shaheen, Abdel-Aziz, Kaplan, Gilaad G, Almishri, Wagdi, Vallerand, Isabelle, Frolkis, Alexandra D, Patten, Scott, Swain, Mark G

“…Depression is prevalent in primary biliary cholangitis (PBC) patients. Our aims were to examine the effects of depression and antidepressants on hepatic…”
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Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: A population‐based study by Myers, Robert P., Shaheen, Abdel Aziz M., Fong, Andrew, Burak, Kelly W., Wan, Alex, Swain, Mark G., Hilsden, Robert J., Sutherland, Lloyd, Quan, Hude

“…The recent epidemiology and outcomes of primary biliary cirrhosis (PBC) in North America are incompletely described, partly due to difficulties in case…”
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A qualitative patient interview study to understand the experience of patients with nonalcoholic steatohepatitis by Swain, Mark G, Pettersson, Billie, Meyers, Oren, Venerus, Meredith, Oscarsson, Jan

“…NASH is a potentially progressive form of NAFLD characterized by hepatocyte injury and liver inflammation which can cause fibrosis. Currently, there are…”
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Protective Role of Interleukin-17 in Murine NKT Cell-Driven Acute Experimental Hepatitis by Wondimu, Zenebech, Santodomingo-Garzon, Tania, Le, Tai, Swain, Mark G

“…NKT cells are highly enriched within the liver. On activation NKT cells rapidly release large quantities of different cytokines which subsequently activate,…”
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Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial by Jones, David, Carbone, Marco, Invernizzi, Pietro, Little, Nicola, Nevens, Frederik, Swain, Mark G, Wiesel, Philippe, Levy, Cynthia

“…There is a real unmet need for primary biliary cholangitis (PBC) treatments that can improve quality of life impacting symptoms. In this post hoc analysis, we…”
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