Search Results - "Swai, Hulda S."

In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems by Semete, Boitumelo, PhD, Booysen, Laetitia, MSc, Lemmer, Yolandy, MSc, Kalombo, Lonji, MSc, Katata, Lebogang, PhD, Verschoor, Jan, PhD, Swai, Hulda S., PhD

“…Abstract The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science…”
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Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies by Shadrack, Daniel M, Swai, Hulda S, Munissi, Joan J E, Mubofu, Egid B, Nyandoro, Stephen S

“…Clinical applications of many small molecules are limited due to poor solubility and lack of controlled release besides lack of other desirable properties…”
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Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at Once Weekly Administration for the Duration of Treatment by Kalombo, Lonji, Lemmer, Yolandy, Semete-Makokotlela, Boitumelo, Ramalapa, Bathabile, Nkuna, Patric, Booysen, Laetitia L L I J, Naidoo, Saloshnee, Hayeshi, Rose, Verschoor, Jan A, Swai, Hulda S

“…Aiming to improve the treatment outcomes of current daily tuberculosis (TB) chemotherapy over several months, we investigated whether nanoencapsulation of…”
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Permeation of PLGA nanoparticles across different in vitro models by Nkabinde, Lindiwe A, Shoba-Zikhali, Lungile N N, Semete-Makokotlela, Boitumelo, Kalombo, Lonji, Swai, Hulda S, Hayeshi, Rose, Naicker, Brendon, Hillie, Thembela K, Hamman, Josias H

“…Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as…”
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A computational study on the role of water and conformational fluctuations in Hsp90 in response to inhibitors by Shadrack, Daniel M., Swai, Hulda S., Hassanali, Ali

“…Molecular chaperone Heat Shock Protein 90 (Hsp90) represents an interesting chemotherapeutic target for cancer treatments as it plays a role in cancer…”
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Solvent effects on molecular encapsulation of Toussantine-A by chitosan nanoparticle: A metadynamics study by Shadrack, Daniel M., Swai, Hulda S.

“…We report a metadynamics study of toussantine-A with chitosan nanoparticle in dimethyl sulfoxide and water in order to assess the solvent related effects on…”
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Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration by Semete, Boitumelo, Booysen, Laetitia, Kalombo, Lonji, Ramalapa, Bathabile, Hayeshi, Rose, Swai, Hulda S.

“…The surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated…”
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Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms by Shadrack, Daniel M., Deogratias, Geradius, Kiruri, Lucy W., Swai, Hulda S., Vianney, John-Mary, Nyandoro, Stephen S.

“…The recent outbreak of SARS-CoV-2 is responsible for high morbidity and mortality rate across the globe. This requires an urgent identification of drugs and…”
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Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis by Lemmer, Yolandy, Kalombo, Lonji, Pietersen, Ray-Dean, Jones, Arwyn T., Semete-Makokotlela, Boitumelo, Van Wyngaardt, Sandra, Ramalapa, Bathabile, Stoltz, Anton C., Baker, Bienyameen, Verschoor, Jan A., Swai, Hulda S., de Chastellier, Chantal

“…The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat…”
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Relaxed complex scheme and molecular dynamics simulation suggests small molecule inhibitor of human TMPRSS2 for combating COVID-19 by Vuai, Said A. H., Ogedjo, Marcelina M., Isaac, Onoka, Sahini, Mtabazi G., Swai, Hulda S., Shadrack, Daniel M.

“…As the coronavirus disease 19 (COVID-19) pandemic continues to pose a health and economic crisis worldwide, the quest for drugs and/or vaccines against the…”
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Review of Agricultural and Rural Development System Models and Frameworks to Support Farming as a Business via Benchmarking: The Case of Tanzania by Kyaruzi, John J, Yonah, Zaipuna O, Swai, Hulda S

“…This paper presents a review of the current state of agricultural and rural development (ARD) system frameworks, focusing on their capabilities and limitations…”
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Potential of Improving the Treatment of Tuberculosis Through Nanomedicine by Semete, Boitumelo, Kalombo, Lonji, Katata, Lebogang, Chelule, Paul, Booysen, Laetitia, Lemmer, Yolandy, Naidoo, Saloshnee, Ramalapa, Bathabile, Hayeshi, Rose, Swai, Hulda S.

“…Current treatment of tuberculosis is inadequate due to lengthy treatment course and drug-related toxicity. To address these setbacks, we developed a…”
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Abrogating the nsp10-nsp16 switching mechanisms in SARS-CoV-2 by phytochemicals from Withania somnifera: a molecular dynamics study by Vuai, Said A. H., Onoka, Isaac, Sahini, Mtabazi G., Swai, Hulda S., Shadrack, Daniel M.

“…The search for therapeutic small molecules and vaccines for Covid-19 treatment is an urgent but evolving topic. The virus has claimed over 3,782,490 lives (as…”
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Antimalarial potential and phytochemical composition of fractions of Lippia kituiensis Vatke (Verbenaceae) growing in Northern Tanzania by Japheth, K. Ng’etich, Hulda, S. Swai, Joseph, M. Njokah, Sabina, W. Wachira, Lilian, C. Koech, Jeremiah, W. Gathirwa

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Pharmacology, Drug Delivery, Biodistribution, Toxicology, PLGA NPs, Commercial NPs by Semete, Boitumelo, Booysen, Laetitia, Lemmer, Yolandy, Kalombo, Lonji, Katata, Lebogang, Verschoor, Jan, Swai, Hulda S

“…The remarkable physicochemical properties of particles in the nanometer range have been proven to address many challenges in the field of science. However, the…”
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Targeted nanodrug delivery systems for the treatment of tuberculosis by Lemmer, Yolandy, Semete, Boitumelo, Booysen, Laetitia, Kalombo, Lonji, Katata, Lebogang, Jones, Arwyn T., Alexander, Cameron, Khati, Makobetsa, Swai, Hulda S., Verschoor, Jan A.

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