Search Results - "Swahn, Marie"

Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease by Jeppsson, Fredrik, Eketjäll, Susanna, Janson, Juliette, Karlström, Sofia, Gustavsson, Susanne, Olsson, Lise-Lotte, Radesäter, Ann-Cathrine, Ploeger, Bart, Cebers, Gvido, Kolmodin, Karin, Swahn, Britt-Marie, von Berg, Stefan, Bueters, Tjerk, Fälting, Johanna

“…β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid precursor protein (APP) and…”
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Characterization of AZD4694, a novel fluorinated Aβ plaque neuroimaging PET radioligand by Juréus, Anders, Swahn, Britt-Marie, Sandell, Johan, Jeppsson, Fredrik, Johnson, Allan E, Johnström, Peter, Neelissen, Jan A.M, Sunnemark, Dan, Farde, Lars, Svensson, Samuel P.S

“…J. Neurochem. (2010) 114, 784-794. Positron emission tomography (PET) radioligands that bind selectively to β-amyloid plaques (Aβ) are promising imaging tools…”
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Video Radiology Reports: A Valuable Tool to Improve Patient-Centered Radiology by Recht, Michael P, Westerhoff, Malte, Doshi, Ankur M, Young, Matthew, Ostrow, Dana, Swahn, Dawn-Marie, Krueger, Sebastian, Thesen, Stefan

“…Improved communication between radiologists and patients is a key component of patient-centered radiology. The purpose of this study was to create…”
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Radiosynthesis of the candidate β-amyloid radioligand [11C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys by Andersson, Jan D., Varnäs, Katarina, Cselényi, Zsolt, Gulyás, Balázs, Wensbo, David, Finnema, Sjoerd J., Swahn, Britt-Marie, Svensson, Samuel, Nyberg, Svante, Farde, Lars, Halldin, Christer

“…β‐Amyloid accumulation is associated with the pathogenesis of Alzheimer's disease (AD). AZD2184, a new radioligand for high‐contrast positron emission…”
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Decreased Tongue Volume Post Radiation by Garber, David, Rotsides, Janine, Abu-Ghanem, Sara, Bandler, Ilana, Smith, Amy, Oyfe, Irina, Swahn, Dawn-Marie, Hagiwara, Mari, Amin, Milan, Johnson, Aaron M.

“…Objectives: To evaluate volume changes within the tongue post chemoradiation therapy (CRT) Study Design: Retrospective review Setting: Academic Medical Center…”
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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

“…Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and…”
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Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides by Swahn, Britt-Marie, Kolmodin, Karin, Karlström, Sofia, von Berg, Stefan, Söderman, Peter, Holenz, Jörg, Berg, Stefan, Lindström, Johan, Sundström, Marie, Turek, Dominika, Kihlström, Jacob, Slivo, Can, Andersson, Lars, Pyring, David, Rotticci, Didier, Öhberg, Liselotte, Kers, Annika, Bogar, Krisztian, von Kieseritzky, Fredrik, Bergh, Margareta, Olsson, Lise-Lotte, Janson, Juliette, Eketjäll, Susanna, Georgievska, Biljana, Jeppsson, Fredrik, Fälting, Johanna

“…The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the discovery of a clinical…”
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Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules by Luker, Tim, Alcaraz, Lilian, Chohan, Kamaldeep K., Blomberg, Niklas, Brown, Dearg S., Butlin, Roger J., Elebring, Thomas, Griffin, Andrew M., Guile, Simon, St-Gallay, Stephen, Swahn, Britt-Marie, Swallow, Steve, Waring, Michael J., Wenlock, Mark C., Leeson, Paul D.

“…A valid PLS-DA model to predict attrition in pre-clinical toxicology for basic oral candidate drugs was built. A combination of aromatic/aliphatic balance,…”
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AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice by Eketjäll, Susanna, Janson, Juliette, Jeppsson, Fredrik, Svanhagen, Alexander, Kolmodin, Karin, Gustavsson, Susanne, Radesäter, Ann-Cathrin, Eliason, Kristina, Briem, Sveinn, Appelkvist, Paulina, Niva, Camilla, Berg, Anna-Lena, Karlström, Sofia, Swahn, Britt-Marie, Fälting, Johanna

“…Aβ, the product of APP (amyloid precursor protein), has been implicated in the pathophysiology of Alzheimer's disease (AD). β-Site APP cleaving enzyme1 (BACE1)…”
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Creation of Novel Cores for β‑Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy by Viklund, Jenny, Kolmodin, Karin, Nordvall, Gunnar, Swahn, Britt-Marie, Svensson, Mats, Gravenfors, Ylva, Rahm, Fredrik

“…In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of…”
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Design and synthesis of 2′-anilino-4,4′-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3 by Swahn, Britt-Marie, Xue, Yafeng, Arzel, Erwan, Kallin, Elisabet, Magnus, Angelika, Plobeck, Niklas, Viklund, Jenny

“…The design and synthesis of new c-Jun N-terminal kinase-3 inhibitors (JNK3) with selectivity against JNK1 and p38α are reported. Compound 18 displayed the best…”
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Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer’s disease patients by Forsberg, Anton, Juréus, Anders, Cselényi, Zsolt, Eriksdotter, Maria, Freund-Levi, Yvonne, Jeppsson, Fredrik, Swahn, Britt-Marie, Sandell, Johan, Julin, Per, Schou, Magnus, Andersson, Jan, Johnström, Peter, Varnäs, Katarina, Halldin, Christer, Farde, Lars, Svensson, Samuel

“…Purpose The aim of this study was to evaluate AZD2995 side by side with AZD2184 as novel PET radioligands for imaging of amyloid-β in Alzheimer’s disease (AD)…”
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Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3 by Swahn, Britt-Marie, Huerta, Fernando, Kallin, Elisabet, Malmström, Jonas, Weigelt, Tatjana, Viklund, Jenny, Womack, Patrick, Xue, Yafeng, Öhberg, Liselotte

“…The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors 4 with selectivity against JNK1 and p38α is reported. The…”
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Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy by Swahn, Britt-Marie, Holenz, Jörg, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, Plobeck, Niklas, Rotticci, Didier, Sehgelmeble, Fernando, Sundström, Marie, Berg, Stefan von, Fälting, Johanna, Georgievska, Biljana, Gustavsson, Susanne, Neelissen, Jan, Ek, Margareta, Olsson, Lise-Lotte, Berg, Stefan

“…The evaluation of a series of bicyclic aminoimidazoles as potent BACE-1 inhibitors is described. The crystal structures of compound 14 and compound 23 in…”
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Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides by Swahn, Britt-Marie, Macsari, Istvan, Viklund, Jenny, Öhberg, Liselotte, Sjödin, Johanna, Neelissen, Jan, Lindquist, Johanna

“…The synthesis and SAR of a new series of LXR agonist is reported. The N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide hits were found in a limited…”
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Recent Progress in the Discovery of Kv7 Modulators by Dorange, Ismet, Swahn, Britt-Marie

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A phase II study of docetaxel weekly in combination with carboplatin every three weeks as first line chemotherapy in stage IIB-IV epithelial ovarian cancer: Neurological toxicity and quality-of-life evaluation by SORBE, Bengt, GRAFLUND, Marianne, NYGREN, Lisa, HORVATH, György, SWAHN, Marie, BOMAN, Karin, BANGSHÖJ, René, LOOD, Margareta, MALMSTRÖM, Henric

“…The purpose of this study was to assess the response rate, toxicity, progression-free survival (PFS) and overall survival (OS) in a series of advanced stage…”
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Phase II study of docetaxel weekly in combination with carboplatin every 3 weeks as first-line chemotherapy in stage IIB to stage IV epithelial ovarian cancer by Sorbe, Bengt, Graflund, Marianne, Horvath, György, Swahn, Marie, Boman, Karin, Bangshöj, René, Lood, Margareta, Malmström, Henric

“…The purpose of this study was to assess the response rate, toxicity, progression-free survival, and overall survival in a series of patients with…”
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New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity by Swahn, Britt-Marie, Claesson, Alf, Pelcman, Benjamin, Besidski, Yevgeni, Molin, Håkan, Sandberg, Mats P., Berge, Odd-Geir

“…The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2-naphthalene-propanoic acid,…”
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Two non-racemic preparations of a piperidine-based NMDA antagonist with analgesic activity by Swahn, Britt-Marie, Edvinsson, Karin M., Kallin, Elisabet, Larsson, Ulf, Berge, Odd-Geir, Molin, Håkan, Pelcman, Benjamin, Claesson, Alf

“…(2 R,3 S,1′ R)-3-(1-Hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 has been synthesized by two different methods. The NMDA receptor binding affinities…”
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