Search Results - "Svingen, Phyllis A"

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD) by Sarmento, Olga F., Svingen, Phyllis A., Xiong, Yuning, Sun, Zhifu, Bamidele, Adebowale O., Mathison, Angela J., Smyrk, Thomas C., Nair, Asha A., Gonzalez, Michelle M., Sagstetter, Mary R., Baheti, Saurabh, McGovern, Dermot P.B., Friton, Jessica J., Papadakis, Konstantinos A., Gautam, Goel, Xavier, Ramnik J., Urrutia, Raul A., Faubion, William A.

“…Regulatory T (Treg) cells expressing the transcription factor FOXP3 play a pivotal role in maintaining immunologic self-tolerance. We and others have shown…”
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Stem Cells for Murine Interstitial Cells of Cajal Suppress Cellular Immunity and Colitis Via Prostaglandin E2 Secretion by Dave, Maneesh, Hayashi, Yujiro, Gajdos, Gabriella B, Smyrk, Thomas C, Svingen, Phyllis A, Kvasha, Sergiy M, Lorincz, Andrea, Dong, Haidong, Faubion, William A, Ordog, Tamas

“…Background & Aims After allogeneic transplantation, murine stem cells (SCs) for interstitial cells of Cajal (ICCs), electrical pacemaker, and neuromodulator…”
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Polycomb Antagonizes p300/CREB-binding Protein-associated Factor to Silence FOXP3 in a Kruppel-like Factor-dependent Manner by Xiong, Yuning, Khanna, Sahil, Grzenda, Adrienne L., Sarmento, Olga F., Svingen, Phyllis A., Lomberk, Gwen A., Urrutia, Raul A., Faubion, William A.

“…Inducible gene expression underlies the epigenetically inherited differentiation program of most immune cells. We report that the promoter of the FOXP3 gene…”
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Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene by Xiong, Yuning, Svingen, Phyllis A, Sarmento, Olga O, Smyrk, Thomas C, Dave, Maneesh, Khanna, Sahil, Lomberk, Gwen A, Urrutia, Raul A, Faubion, Jr, William A

“…Inducible gene expression, which requires chromatin remodeling on gene promoters, underlies the epigenetically inherited differentiation program of most immune…”
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Components of the Cell Death Machine and Drug Sensitivity of the National Cancer Institute Cell Line Panel by SVINGEN, Phyllis A, LOEGERING, David, REED, John C, LAZEBNIK, Yuri A, KAUFMANN, Scott H, RODRIQUEZ, Joe, XUE WEI MENG, MESNER, Peter W, HOLBECK, Susan, MONKS, Anne, KRAJEWSKI, Stan, SCUDIERO, Dominic A, SAUSVILLE, Edward A

“…Purpose: According to some studies, susceptibility of cells to anticancer drug-induced apoptosis is markedly inhibited by targeted deletion of genes encoding…”
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BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease by Gonzalez, Michelle M, Bamidele, Adebowale O, Svingen, Phyllis A, Sagstetter, Mary R, Smyrk, Thomas C, Gaballa, Joseph M, Hamdan, Feda H, Kosinsky, Robyn Laura, Gibbons, Hunter R, Sun, Zhifu, Ye, Zhenqing, Nair, Asha, Ramos, Guilherme P, Neto, Manuel B. Braga, Wixom, Alexander Q, Mathison, Angela J, Johnsen, Steven A, Urrutia, Raul, Faubion, William A., Jr

“…[FOXP3.sup.+] Tregs are expanded within the inflamed intestine of human Crohn's disease, yet FOXP3-mediated gene repression within these cells is lost. The…”
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Lack of Correlation between Caspase Activation and Caspase Activity Assays in Paclitaxel-treated MCF-7 Breast Cancer Cells by Kottke, Timothy J., Blajeski, April L., Meng, X. Wei, Svingen, Phyllis A., Ruchaud, Sandrine, Mesner, Peter W., Boerner, Scott A., Samejima, Kumiko, Henriquez, Nicholas V., Chilcote, Tamie J., Lord, Janet, Salmon, Michael, Earnshaw, William C., Kaufmann, Scott H.

“…MCF-7 human breast cancer cells are widely utilized to study apoptotic processes. Recent studies demonstrated that these cells lack procaspase-3. In the…”
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Phase I and Pharmacologic Study of Infusional Topotecan and Carboplatin in Relapsed and Refractory Acute Leukemia by KAUFMANN, Scott H, KARP, Judith E, LITZOW, Mark R, SLOAN, Jeff A, REID, Joel M, AMES, Matthew M, ADJEI, Alex A, ERLICHMAN, Charles, LETENDRE, Louis, KOTTKE, Timothy J, SAFGREN, Stephanie, GREER, Jackie, GOJO, Ivana, ATHERTON, Pamela, SVINGEN, Phyllis A, LOEGERING, David A

“…Purpose: To assess the maximum tolerated dose, toxicities, pharmacokinetics, and antileukemic activity of topotecan and carboplatin in adults with recurrent or…”
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Disruption of FOXP3–EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation by Bamidele, Adebowale O, Svingen, Phyllis A, Sagstetter, Mary R, Sarmento, Olga F, Gonzalez, Michelle, Braga Neto, Manuel B, Kugathasan, Subra, Lomberk, Gwen, Urrutia, Raul A, Faubion, William A

“…Background & Aims Forkhead box protein 3 (FOXP3)+ regulatory T cell (Treg) dysfunction is associated with autoimmune diseases; however, the mechanisms…”
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The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival by Rahman, Meher K, Midtling, Emilie H, Svingen, Phyllis A, Xiong, Yuning, Bell, Michael P, Tung, Jeanne, Smyrk, Tom, Egan, Larry J, Faubion, Jr, William A

“…The expression of pathogen recognition receptors in human FOXP3+ T regulatory cells is established, yet the function of these receptors is currently obscure…”
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Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines by Kalli, Kimberly R, Devine, Kathryn E, Cabot, Myles C, Arnt, Christina R, Heldebrant, Michael P, Svingen, Phyllis A, Erlichman, Charles, Hartmann, Lynn C, Conover, Cheryl A, Kaufmann, Scott H

“…The mechanism of action of fenretinide, a synthetic retinoid currently undergoing testing as a chemopreventive and chemotherapeutic agent, is incompletely…”
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Mo1712 Kruppel-Like Factor Klf10 Regulates Transforming Growth Factor Receptor Signaling in CD8+ Cytotoxic T Lymphocytes by Papadakis, Konstantinos A, Krempski, James, Dave, Maneesh, Svingen, Phyllis A, Faubion, William A

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261 Adult Stem Cells for Murine Interstitial Cells of Cajal Suppress Cellular Immunity via PGE2 Secretion by Dave, Maneesh, Gajdos, Gabriella B, Svingen, Phyllis A, Faubion, William A, Ordog, Tamas

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FOXP3 regulates TLR10 expression in human T regulatory cells by Bell, Michael P, Svingen, Phyllis A, Rahman, Meher K, Xiong, Yuning, Faubion, Jr, William A

“…Although functionally relevant TLRs can be expressed on human T regulatory (Treg) cells, little is known about the transcriptional control of their expression…”
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A Novel Role for Kruppel-like Factor 14 (KLF14) in T-Regulatory Cell Differentiation by Sarmento, Olga F, Svingen, Phyllis A, Xiong, Yuning, Xavier, Ramnik J, McGovern, Dermot, Smyrk, Thomas C, Papadakis, Konstantinos A, Urrutia, Raul A, Faubion, William A

“…Background & Aims Kruppel-like Factor 14 (KLF14) proteins function as epigenetic reprogramming factors during cell differentiation in many cell populations and…”
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275 Adult Stem Cells for Murine Interstitial Cells of Cajal (ICC) Mediate Immunosuppression In Vitro by Dave, Maneesh, Hayashi, Yujiro, Khanna, Sahil, Bardsley, Michael R, Svingen, Phyllis A, Faubion, William A, Ordog, Tamas

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Sa1787 Kruppel Like Factor-10 Regulates Adaptive FOXP3+ Treg Cell Development in a TGFβ Dependent Manner by Khanna, Sahil, Svingen, Phyllis A, Dave, Maneesh, Xiong, Yuning, Sarmento, Olga F, Smyrk, Thomas C, Faubion, William A

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Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse by Kaufmann, Scott H., Karp, Judith E., Svingen, Phyllis A., Krajewski, Stan, Burke, Philip J., Gore, Steven D., Reed, John C.

“…Bcl-2, Bcl-xL, and Mcl-1 are three related intracellular polypeptides that have been implicated as negative regulators of apoptosis. In contrast, the partner…”
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Tu1923 The Effect of Antigen Oxidation and TGF on NaïVE T Cell Phenotype and Proliferation by Khanna, Sahil, Tremaine, William I, Dave, Maneesh, Svingen, Phyllis A, Xiong, Yuning, Linden, David R, Faubion, William A

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A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity by Adjei, A A, Erlichman, C, Davis, J N, Cutler, D L, Sloan, J A, Marks, R S, Hanson, L J, Svingen, P A, Atherton, P, Bishop, W R, Kirschmeier, P, Kaufmann, S H

“…Farnesyl protein transferase (FT), an enzyme that catalyzes the first step in the posttranslational modification of ras and a number of other polypeptides, has…”
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