Search Results - "Svihalkova Sindlerova, Lenka"

Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions by Kolářová, Hana, Ambrůzová, Barbora, Švihálková Šindlerová, Lenka, Klinke, Anna, Kubala, Lukáš

“…The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall. The glycocalyx is…”
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Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes by Šafaříková, Eva, Švihálková Šindlerová, Lenka, Stříteský, Stanislav, Kubala, Lukáš, Vala, Martin, Weiter, Martin, Víteček, Jan

“…•TIPS-Pentacene, DPP(TBFu)2 and P3HT were water stable; PEDOT:PSS produced leachates.•Native TIPS-Pentacene, DPP(TBFu)2, P3HT and PEDOT:PSS showed limited…”
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Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin by Adamovsky, Ondrej, Moosova, Zdena, Pekarova, Michaela, Basu, Amrita, Babica, Pavel, Svihalkova Sindlerova, Lenka, Kubala, Lukas, Blaha, Ludek

“…Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of…”
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The isolation and characterization of lipopolysaccharides from Microcystis aeruginosa, a prominent toxic water bloom forming cyanobacteria by Bláhová, Lucie, Adamovský, Ondřej, Kubala, Lukáš, Švihálková Šindlerová, Lenka, Zounková, Radka, Bláha, Luděk

“…Massive toxic blooms of cyanobacteria represent a major threat to water supplies worldwide, yet serious gaps exist in understanding their complex toxic…”
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Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines by Vondracek, J, Svihalkova-Sindlerova, L, Pencikova, K, Marvanova, S, Krcmar, P, Ciganek, M, Neca, J, Trosko, J.E, Upham, B, Kozubik, A

“…Alkylated polycyclic aromatic hydrocarbons (PAHs) are important environmental pollutants. In the present study, we determined levels of monomethylated…”
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The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells by Andrysík, Zdenek, Vondrácek, Jan, Machala, Miroslav, Krcmár, Pavel, Svihálková-Sindlerová, Lenka, Kranz, Anne, Weiss, Carsten, Faust, Dagmar, Kozubík, Alois, Dietrich, Cornelia

“…Disruption of cell proliferation control by polycyclic aromatic hydrocarbons (PAHs) may contribute to their carcinogenicity. We investigated role of the aryl…”
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High effectiveness of platinum(IV) complex with adamantylamine in overcoming resistance to cisplatin and suppressing proliferation of ovarian cancer cells in vitro by Kozubík, Alois, Horváth, Viktor, Švihálková-Šindlerová, Lenka, Souček, Karel, Hofmanová, Jiřina, Sova, Petr, Kroutil, Aleš, Žák, František, Mistr, Adolf, Turánek, Jaroslav

“…[( OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)], coded as LA-12, is an octahedral platinum(IV) complex containing a bulky hydrophobic…”
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LA-12 Overcomes Confluence-dependent Resistance of HT-29 Colon Cancer Cells to Pt (II) Compounds by SVIHALKOVA-SINDLEROVA, Lenka, FOLTINOVA, Vendula, VACULOVA, Alena, HORVATH, Viktor, SOUCEK, Karel, SOVA, Petr, HOFMANOVA, Jirina, KOZUBIK, Alois

“…LA-12 is a new platinum (IV) drug with promising cytotoxic effects in a wide range of cancer cell lines. Its confluence-dependent effects were compared with…”
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β-Naphthoflavone and 3′-methoxy-4′-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver ‘stem-like’ cells by Zatloukalová, Jiřina, Švihálková-Šindlerová, Lenka, Kozubík, Alois, Krčmář, Pavel, Machala, Miroslav, Vondráček, Jan

“…Both natural and synthetic flavonoids are known to interact with the aryl hydrocarbon receptor (AhR); however, their agonist/antagonist properties in vitro…”
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Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells by Horváth, Viktor, Blanářová, Olga, Švihálková-Šindlerová, Lenka, Souček, Karel, Hofmanová, Jiřina, Sova, Petr, Kroutil, Aleš, Fedoročko, Peter, Kozubík, Alois

“…The resistance of tumor cells to cisplatin remains a major cause of treatment failure in cancer patients. In this study, the ability of Pt(IV) complex with…”
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Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin by Horváth, Viktor, Soucek, Karel, Svihálková-Sindlerová, Lenka, Vondrácek, Jan, Blanárová, Olga, Hofmanová, Jirina, Sova, Petr, Kozubík, Alois

“…Platinum (IV) derivative with adamantylamine-LA-12-represents a new generation of highly efficient anti-cancer drug derived from cisplatin and is currently in…”
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The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells by Binó, Lucia, Kučera, Jan, Štefková, Kateřina, Švihálková Šindlerová, Lenka, Lánová, Martina, Kudová, Jana, Kubala, Lukáš, Pacherník, Jiří

“…Hypoxic conditions are suggested to affect the differentiation status of stem cells (SC), including embryonic stem cells (ESC). Hypoxia inducible factor (HIF)…”
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Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha by Pekarova, Michaela, Koudelka, Adolf, Kolarova, Hana, Ambrozova, Gabriela, Klinke, Anna, Cerna, Anna, Kadlec, Jaroslav, Trundova, Maria, Sindlerova Svihalkova, Lenka, Kuchta, Radek, Kuchtova, Zdenka, Lojek, Antonin, Kubala, Lukas

“…Abstract Pulmonary hypertension (PH), associated with imbalance in vasoactive mediators and massive remodeling of pulmonary vasculature, represents a serious…”
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Immunomodulatory effects of cyanobacterial toxin cylindrospermopsin on innate immune cells by Moosova, Zdena, Pekarova, Michaela, Sindlerova, Lenka Svihalkova, Vasicek, Ondrej, Kubala, Lukas, Blaha, Ludek, Adamovsky, Ondrej

“…Cylindrospermopsin (CYN), a cyanobacterial toxin, is an important water pollutant with broad biological activity. It has been known mainly from tropical areas,…”
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β-Νaphthoflavone and 3' -methoxy -4' -nitroflavone exert ambiguous effects on Αh receptor-dependent cell proliferation and gene expression in rat liver 'stem-like' cells by ZATLOUKALOVA, Jirina, SVIHALKOVA-SINDLEROVA, Lenka, KOZUBIK, Alois, KRCMAR, Pauel, MACHALA, Miroslav, VONDRACEK, Jan

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Concentrations of methylated naphthalenes, anthracenes and phenathrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines by Vondracek, Jan, Svihalkova-Sindlerova, Lenka, Pencikova, Katerina, Marvanova, Sona, Krcmar, Pavel, Ciganek, Miroslav, Neca, Jiri, Trosko, James, Upham, Brad, Kozubik, Alois, Machala, Miroslav

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The effects of puwainaphycins F on Caco-2 cell line as a model of the intestinal barrier by Vašíček, Ondřej, Hrouzek, Pavel, Hájek, Jan, Kubala, Lukáš, Babica, Pavel, Šindlerová, Lenka Švihálková

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7H-Dibenzo[c,g]carbazole and 5,9-dimethyldibenzo[c,g]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial 'stem-like' cells by Vondrácek, Jan, Svihálková-Sindlerová, Lenka, Pencíková, Katerina, Krcmár, Pavel, Andrysík, Zdenek, Chramostová, Katerina, Marvanová, Sona, Valovicová, Zuzana, Kozubík, Alois, Gábelová, Alena, Machala, Miroslav

“…Immature liver progenitor cells have been suggested to be an important target of hepatotoxins and hepatocarcinogens. The goal of the present study was to…”
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