Search Results - "Sverdlov, E.D"

Activation of IGF/IGF-IR signaling pathway fails to induce epithelial-mesenchymal transition in pancreatic cancer cells by Kopantzev, E.P., Kopantseva, M.R., Grankina, E.V., Mikaelyan, A., Egorov, V.I., Sverdlov, E.D.

“…Pancreatic cancer stromal cells produce various protein factors, which presumably provide cancer cells with drug resistance and may influence their ability to…”
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Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter by Didych, D.A., Shamsutdinov, M.F., Smirnov, N.A., Akopov, S.B., Monastyrskaya, G.S., Uspenskaya, N.Y., Nikolaev, L.G., Sverdlov, E.D.

“…Head-to-head genes with a short distance between their transcription start sites may constitute up to 10% of all genes in the genomes of various species. It…”
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Only those genes of the KIAA1245 gene subfamily that contain HERV(K) LTRs in their introns are transcriptionally active by Illarionova, A.E, Vinogradova, T.V, Sverdlov, E.D

“…Abstract Insertion of LTRs into some genome locations might seriously affect regulation of the neighboring genes expression. This hypothesis is widely accepted…”
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Tissue specificity of enhancer and promoter activities of a HERV-K(HML-2) LTR by Ruda, V.M, Akopov, S.B, Trubetskoy, D.O, Manuylov, N.L, Vetchinova, A.S, Zavalova, L.L, Nikolaev, L.G, Sverdlov, E.D

“…Transient expression of a luciferase reporter gene was used to evaluate tissue-specific promoter and enhancer activities of a solitary extraviral long terminal…”
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Unsolvable Problems of Biology: It Is Impossible to Create Two Identical Organisms, to Defeat Cancer, or to Map Organisms onto Their Genomes by Sverdlov, E. D.

“…The review is devoted to unsolvable problems of biology. 1) Problems unsolvable due to stochastic mutations occurring during DNA replication that make it…”
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Cancer Stem Complex, Not a Cancer Stem Cell, Is the Driver of Cancer Evolution by Sverdlov, E. D., Chernov, I. P.

“…Here, we put forward the hypothesis on the mechanism of functioning of cancer stem cells, provided that they exist. The hypothesis is based on the following…”
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Multidimensional complexity of cancer. Simple solutions are needed by Sverdlov, E. D.

“…Cancer is a complex system. Tumor complexity is determined not only by genetic and epigenetic heterogeneity, but also by a huge number of interactions between…”
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PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer by Vinogradova, T. V., Sverdlov, E. D.

“…Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits…”
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Destabilase from the medicinal leech is a representative of a novel family of lysozymes by Zavalova, L.L., Baskova, I.P., Lukyanov, S.A., Sass, A.V., Snezhkov, E.V., Akopov, S.B., Artamonova, I.I., Archipova, V.S., Nesmeyanov, V.A., Kozlov, D.G., Benevolensky, S.V., Kiseleva, V.I., Poverenny, A.M., Sverdlov, E.D.

“…Intrinsic lysozyme-like activity was demonstrated for destabilase from the medicinal leech supported by (1) high specific lysozyme activity of the highly…”
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Fibroblast growth factors and their effects in pancreas organogenesis by Gnatenko, D A, Kopantzev, E P, Sverdlov, E D

“…Fibroblast growth factors (FGF) - growth factors that regulate many important biological processes, including proliferation and differentiation of embryonic…”
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Role of fibroblast growth factors in pancreatic cancer by Gnatenko, D A, Kopantsev, E P, Sverdlov, E D

“…Fibroblast growth factors belong to a family of growth factors that are involved in various processes in organism and have a wide range of biological…”
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Enhanced Vector Design for Cancer Gene Therapy with Hierarchical Enhancement of Therapeutic Transgene Expression by Kostina, M B, Sass, A V, Stukacheva, E A, Korobko, I V, Sverdlov, E D

“…A set of vectors for Cre recombinase-dependent expression of the hybrid suicidal FCU1 transgene was constructed, including a two-plasmid system wherein the…”
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Expression of Therapeutic Gene FCU1 Sensitizes Pancreatic Cancer Cells to 5-Fluorocytosine and Enhances the Cytotoxic Effect of 5-Fluorouracil by Kopantsev, E. P., Kostina, M. B., Grankina, E. V., Kopantseva, M. R., Egorov, V. I., Sverdlov, E. D.

“…Hybrid therapeutic gene FCU1 gene was cloned into a lentiviral expression vector and the therapeutic effect of its expression was studied in three pancreatic…”
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Assay of insulator enhancer-blocking activity with the use of transient transfection by Smirnov, N. A., Didych, D. A., Akopov, S. B., Nikolaev, L. G., Sverdlov, E. D.

“…We used a transient transfection of cultured cells with linearized plasmids to analyze the enhancer-blocking activity of potential insulators including the…”
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Application of mRNA regulatory regions to improve tumor specificity of transgene expression by Shepelev, M V, Korobko, E V, Georgiev, G P, Sverdlov, E D, Korobko, I V

“…Efficiency and specificity are two key attributes of anti-cancer drugs including genetic therapeutic agents. We suggest a way to improve specificity of gene…”
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Expression of chicken CTCF gene in COS-1 cells and partial purification of CTCF protein by Kotova, E. S., Sorokina, I. V., Akopov, S. B., Nikolaev, L. G., Sverdlov, E. D.

“…The chicken gene for transcription factor CTCF was expressed in COS-1 mammalian cells. The CTCF protein containing polyhistidine tag was partially purified…”
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Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity by Nikolaev, L G, Akopov, S B, Didych, D A, Sverdlov, E D

“…The CTCF transcription factor is an 11 zinc fingers multifunctional protein that uses different zinc finger combinations to recognize and bind different sites…”
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Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines by Mityaev, M. V., Kopantzev, E. P., Buzdin, A. A., Vinogradova, T. V., Sverdlov, E. D.

“…We have revealed evolutionarily conserved regions in a 4500-bp DNA sequence 5′-adjacent to the survivin ( BIRC5 ) gene. In the transcribed region of the BIRC5…”
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Functional dissection of an enhancer-like element located within the second intron of the human U2AF1L4 gene by Didych, D. A., Smirnov, N. A., Kotova, E. S., Akopov, S. B., Nikolaev, L. G., Sverdlov, E. D.

“…A detailed functional and evolutionary analysis of an enhancer element of the human genome (enhancer 12) located in the second intron of the U2AF1L4 gene,…”
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Promoters with cancer cell-specific activity for melanoma gene therapy by Pleshkan, V V, Alekseenko, I V, Zinovyeva, M V, Vinogradova, T V, Sverdlov, E D

“…Melanoma is one of the most aggressive tumors. It develops from pigment-forming cells (melanocytes) and results in a high number of lethal outcomes. The use of…”
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