Search Results - "Sverdlov, E"

Unsolvable Problems of Biology: It Is Impossible to Create Two Identical Organisms, to Defeat Cancer, or to Map Organisms onto Their Genomes by Sverdlov, E. D.

“…The review is devoted to unsolvable problems of biology. 1) Problems unsolvable due to stochastic mutations occurring during DNA replication that make it…”
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Multidimensional complexity of cancer. Simple solutions are needed by Sverdlov, E. D.

“…Cancer is a complex system. Tumor complexity is determined not only by genetic and epigenetic heterogeneity, but also by a huge number of interactions between…”
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Cancer Stem Complex, Not a Cancer Stem Cell, Is the Driver of Cancer Evolution by Sverdlov, E. D., Chernov, I. P.

“…Here, we put forward the hypothesis on the mechanism of functioning of cancer stem cells, provided that they exist. The hypothesis is based on the following…”
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PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer by Vinogradova, T. V., Sverdlov, E. D.

“…Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits…”
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Incremental Science: Papers and Grants, Yes; Discoveries, No by Sverdlov, E. D.

“…Today, the effectiveness of scientific research is increasingly often determined by the size of grants obtained, the number of publications, and the level of…”
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Hydrodynamic Low-Frequency Regimes of Unstable Combustion and Methods of Their Suppression in Low-Emission Combustors of Gas-Turbine Units by Sverdlov, E. D., Doubovitsky, A. N., Lebedev, A. B.

“…The mechanisms of excitation of low-frequency unstable combustion of a methane–air mixture in full-scale low-emission combustors are experimentally studied…”
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Conceptual Design of a Low-Emission Combustor for an Industrial Natural Gas Turbine with NO and CO Emission Less than 5 ppm by Sverdlov, E. D., Dubovitskii, A. N., Lebedev, A. B.

“…This paper presents an analysis of the hydrodynamic and physicochemical characteristics of flow and combustion in a low-emission combustor (LEC) that differs…”
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Activation of IGF/IGF-IR signaling pathway fails to induce epithelial-mesenchymal transition in pancreatic cancer cells by Kopantzev, E.P., Kopantseva, M.R., Grankina, E.V., Mikaelyan, A., Egorov, V.I., Sverdlov, E.D.

“…Pancreatic cancer stromal cells produce various protein factors, which presumably provide cancer cells with drug resistance and may influence their ability to…”
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Properties, functions, and therapeutic prospects of enhancer RNAs by Kashkin, K. N., Sverdlov, E. D.

“…The minireview is dedicated to recently described enhancer RNAs (eRNAs), which are products of enhancer transcription. Features and putative functions of eRNAs…”
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Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells by Gnatenko, D. A., Kopantzev, E. P., Sverdlov, E. D.

“…Stimulation of BxPC-3, Panc-1, and MIA PaCA-2 pancreatic cancer cells with EGF, HGF, FGF-1, FGF-2, FGF-7, and FGF-10 growth factors caused changes in the…”
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Poised RNA polymerase II and master regulation in Metazoa by Kashkin, K. N., Sverdlov, E. D.

“…In this review, we discuss mechanisms of the transcription pausing of RNA polymerase II and its poised state. The important features of poised promoters and…”
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Fundamental taboos of biology by Sverdlov, E. D.

“…This paper formulates some taboos relating to living systems and cognition of these systems: in nature, there exist no two identical living complex…”
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Functional significance of a putative Sp1 transcription factor binding site in the survivin gene promoter by Mityaev, M. V, Kopantzev, E. P, Buzdin, A. A, Vinogradova, T. V, Sverdlov, E. D

“…We sequenced 1500-bp genomic DNA regions upstream from the survivin gene (BIRC5). DNA was isolated from human placenta and tumors of patients with diagnosed…”
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Expression of the FAP gene in non-fibroblast human cell lines. Development of cancer-associated fibroblast models by Tyulkina, D. V., Pleshkan, V. V., Alekseenko, I. V., Kopantseva, M. R., Sverdlov, E. D.

“…The fibroblast activation protein (FAP) is selectively expressed in cancer-associated fibroblasts (CAFs) and facilitates tumor progression, which makes this…”
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Suppression Subtractive Hybridization: A Method for Generating Differentially Regulated or Tissue-Specific cDNA Probes and Libraries by Diatchenko, Luda, Lau, Yun-Fai Chris, Campbell, Aaron P., Chenchik, Alex, Moqadam, Fauzia, Huang, Betty, Lukyanov, Sergey, Lukyanov, Konstantin, Gurskaya, Nadya, Sverdlov, Eugene D., Siebert, Paul D.

“…A new and highly effective method, termed suppression subtractive hybridization (SSH), has been developed for the generation of subtracted cDNA libraries. It…”
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Cancer–stroma interactions as a target for cancer treatment by Alekseenko, I. V., Pleshkan, V. V., Sverdlov, E. D.

“…During tumor evolution, cancer cells use the tumor-stroma crosstalk to reorganize the microenvironment for maximum robustness of tumor. The success of immune…”
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KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers by Zinovyeva, M. V., Kostina, M. B., Chernov, I. P., Kondratyeva, L. G., Sverdlov, E. D.

“…Pancreatic cancer is one of the most aggressive tumor types characterized by chemotherapy resistance and high metastatic activity. Recent studies revealed new…”
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A Universal Tumor-Specific Promoter for Cancer Gene Therapy by Alekseenko, I. V., Pleshkan, V. V., Sass, A. V., Filyukova, O. B., Snezhkov, E. V., Sverdlov, E. D.

“…An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters was constructed. Studies in in…”
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Correlation between Expression of KLF5 and ZEB1 Transcription Factor Genes in Pancreatic Cancer by Zinovyeva, M. V., Nikolaev, L. G., Kondratyeva, L. G., Vinogradova, T. V., Sverdlov, E. D.

“…The mRNA content of the transcription factors KLF5 and ZEB1 was studied in pancreatic tumor tissues and in fetal and normal pancreas. Transcription of these…”
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Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter by Didych, D.A., Shamsutdinov, M.F., Smirnov, N.A., Akopov, S.B., Monastyrskaya, G.S., Uspenskaya, N.Y., Nikolaev, L.G., Sverdlov, E.D.

“…Head-to-head genes with a short distance between their transcription start sites may constitute up to 10% of all genes in the genomes of various species. It…”
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