Search Results - "Svedin, Emma"

A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes by Stone, Virginia M., Hankaniemi, Minna M., Svedin, Emma, Sioofy-Khojine, Amirbabak, Oikarinen, Sami, Hyöty, Heikki, Laitinen, Olli H., Hytönen, Vesa P., Flodström-Tullberg, Malin

“…Aims/hypothesis Epidemiological studies suggest a role for Coxsackievirus B (CVB) serotypes in the pathogenesis of type 1 diabetes, but their actual…”
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New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms by Laitinen, Olli H., Svedin, Emma, Kapell, Sebastian, Hankaniemi, Minna M., Larsson, Pär G., Domsgen, Erna, Stone, Virginia M., Määttä, Juha A.E., Hyöty, Heikki, Hytönen, Vesa P., Flodström-Tullberg, Malin

“…•Antibodies to Coxsackievirus B proteases 2A and 3C were generated and characterized.•The antibodies recognized a wide spectrum of enterovirus species B…”
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Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells by Pedersen, Morten Gram, Salunkhe, Vishal Ashok, Svedin, Emma, Edlund, Anna, Eliasson, Lena

“…Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent…”
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Enteroviral proteases: structure, host interactions and pathogenicity by Laitinen, Olli H., Svedin, Emma, Kapell, Sebastian, Nurminen, Anssi, Hytönen, Vesa P., Flodström-Tullberg, Malin

“…Summary Enteroviruses are common human pathogens, and infections are particularly frequent in children. Severe infections can lead to a variety of diseases,…”
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Composition and functionality of the intrahepatic innate lymphoid cell‐compartment in human nonfibrotic and fibrotic livers by Forkel, Marianne, Berglin, Lena, Kekäläinen, Eliisa, Carlsson, Adrian, Svedin, Emma, Michaëlsson, Jakob, Nagasawa, Maho, Erjefält, Jonas S, Mori, Michiko, Flodström‐Tullberg, Malin, Bergquist, Annika, Ljunggren, Hans‐Gustaf, Westgren, Magnus, Lindforss, Ulrik, Friberg, Danielle, Jorns, Carl, Ellis, Ewa, Björkström, Niklas K, Mjösberg, Jenny

“…Human innate lymphoid cells have been described to exist in different organs, with functional deregulation of these cells contributing to several disease…”
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Coxsackievirus counters the host innate immune response by blocking type III interferon expression by Lind, Katharina, Svedin, Emma, Domsgen, Erna, Kapell, Sebastian, Laitinen, Olli H, Moll, Markus, Flodström-Tullberg, Malin

“…Type I IFNs play an important role in the immune response to enterovirus infections. Their importance is underscored by observations showing that many…”
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Enterovirus Infections in Type 1 Diabetes and Cystic Fibrosis: Antiviral Defence and Viral Immune Evasion Strategies by Svedin, Emma

“…Enteroviruses are common viruses which cause infections in humans that usually result in mild flu-like symptoms before viral clearance. However, in some cases…”
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Enteroviral proteases: structure, host interactions and pathogenicity: Pathogenicity of enteroviral proteases by Laitinen, Olli H., Svedin, Emma, Kapell, Sebastian, Nurminen, Anssi, Hytönen, Vesa P., Flodström-Tullberg, Malin

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Defective exocytosis and processing of insulin in a cystic fibrosis mouse model by Edlund, A, Barghouth, M, Hühn, M, Abels, M, Esguerra, J S E, Mollet, I G, Svedin, E, Wendt, A, Renström, E, Zhang, E, Wierup, N, Scholte, B J, Flodström-Tullberg, M, Eliasson, L

“…Cystic fibrosis-related diabetes (CFRD) is a common complication for patients with cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis…”
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Cystic fibrosis bronchial epithelial cells have impaired ability to activate vitamin D by Pincikova, Terezia, Svedin, Emma, Domsgen, Erna, Flodström-Tullberg, Malin, Hjelte, Lena

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A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense by Svedin, Emma, Utorova, Renata, Hühn, Michael H., Larsson, Pär G., Stone, Virginia M., Garimella, Manasa, Lind, Katharina, Hägglöf, Thomas, Pincikova, Terezia, Laitinen, Olli H., McInerney, Gerald M., Scholte, Bob, Hjelte, Lena, Karlsson, Mikael C. I., Flodström-Tullberg, Malin

“…Acute respiratory virus infections predispose the cystic fibrosis (CF) lung to chronic bacterial colonization, which contributes to high mortality. For reasons…”
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Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas by Richardson, Sarah J., Leete, Pia, Dhayal, Shalinee, Russell, Mark A., Oikarinen, Maarit, Laiho, Jutta E., Svedin, Emma, Lind, Katharina, Rosenling, Therese, Chapman, Nora, Bone, Adrian J., Foulis, Alan K., Frisk, Gun, Flodstrom-Tullberg, Malin, Hober, Didier, Hyoty, Heikki, Morgan, Noel G.

“…Aims/hypothesis Enteroviral infection has been implicated in the development of islet autoimmunity in type 1 diabetes and enteroviral antigen expression has…”
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New Coxsackievirus 2A pro and 3C pro protease antibodies for virus detection and discovery of pathogenic mechanisms by Laitinen, Olli H, Svedin, Emma, Kapell, Sebastian, Hankaniemi, Minna M, Larsson, Pär G, Domsgen, Erna, Stone, Virginia M, Määttä, Juha A E, Hyöty, Heikki, Hytönen, Vesa P, Flodström-Tullberg, Malin

“…Enteroviruses (EVs), such as the Coxsackie B-viruses (CVBs), are common human pathogens, which can cause severe diseases including meningitis, myocarditis and…”
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Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection by Hühn, Michael H, McCartney, Stephen A, Lind, Katharina, Svedin, Emma, Colonna, Marco, Flodström-Tullberg, Malin

“…Abstract Coxsackievirus infections are associated with severe diseases such as myocarditis, meningitis and pancreatitis. To study the contribution of the…”
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Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter] by Richardson, Sarah J., Leete, Pia, Dhayal, Shalinee, Russell, Mark A., Oikarinen, Maarit, Laiho, Jutta E., Svedin, Emma, Lind, Katharina, Rosenling, Therese, Chapman, Nora, Bone, Adrian J., Foulis, Alan K., Frisk, Gun, Flodström-Tullberg, Malin, Hober, Didier, Hyoty, Heikki, Pugliese, Alberto, Morgan, Noel G.

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