Search Results - "Suzuma, Izumi"

Erythropoietin as a Retinal Angiogenic Factor in Proliferative Diabetic Retinopathy by Watanabe, Daisuke, Suzuma, Kiyoshi, Suzuma, Izumi, Matsui, Shigeyuki, Kurimoto, Masafumi, Kiryu, Junichi, Kita, Mihori, Ohashi, Hirokazu, Ojima, Tomonari, Murakami, Tomoaki, Kobayashi, Toshihiro, Masuda, Seiji, Nagao, Masaya, Yoshimura, Nagahisa, Takagi, Hitoshi

“…This study measured vitreous levels of erythropoietin and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy and other eye…”
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Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR, Flt1, and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells by Suzuma, Kiyoshi, Naruse, Keiko, Suzuma, Izumi, Takahara, Noriko, Ueki, Kohjiro, Aiello, Lloyd P., King, George L.

“…Fibroblastic proliferation accompanies many angiogenesis-related retinal and systemic diseases. Since connective tissue growth factor (CTGF) is a potent…”
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Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization by Suzuma, Kiyoshi, Takahara, Noriko, Suzuma, Izumi, Isshiki, Keiji, Ueki, Kohjiro, Leitges, Michael, Aiello, Lloyd Paul, King, George L

“…Retinal neovascularization is a major cause of blindness and requires the activities of several signaling pathways and multiple cytokines. Activation of…”
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Suppression of Fas‐FasL‐induced endothelial cell apoptosis prevents diabetic blood‐retinal barrier breakdown in a model of streptozotocin‐induced diabetes by Joussen, Antonia M., Poulaki, Vassiliki, Mitsiades, Nicholas, Cai, Wen‐yi, Suzuma, Izumi, Pak, John, Ju, Shyr‐Te, Rook, Susan L., Esser, Peter, Mitsiades, Constantin, Kirchhof, Bernd, Adamis, Anthony P., Paul Aiello, Lloyd

“…ABSTRACT Diabetic macular edema, resulting from increased microvascular permeability, is the most prevalent cause of vision loss in diabetes. The mechanisms…”
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EphrinA1 Inhibits Vascular Endothelial Growth Factor-Induced Intracellular Signaling and Suppresses Retinal Neovascularization and Blood-Retinal Barrier Breakdown by Ojima, Tomonari, Takagi, Hitoshi, Suzuma, Kiyoshi, Oh, Hideyasu, Suzuma, Izumi, Ohashi, Hirokazu, Watanabe, Daisuke, Suganami, Eri, Murakami, Tomoaki, Kurimoto, Masafumi, Honda, Yoshihito, Yoshimura, Nagahisa

“…The Eph receptor/ephrin system is a recently discovered regulator of vascular development during embryogenesis. Activation of EphA2, one of the Eph receptors,…”
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Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis by Jiang, Zhen Y., He, Zhiheng, King, Benjamin L., Kuroki, Tatsuya, Opland, Darren M., Suzuma, Kiyoshi, Suzuma, Izumi, Ueki, Kohjiro, Kulkarni, Rohit N., Kahn, C.Ronald, King, George L.

“…The effects of insulin on vascular endothelial growth factor (VEGF) expression in cultured vascular cells and in angiogenesis were characterized. Insulin…”
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Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells by Yi, Xianjin, Schubert, Markus, Peachey, Neal S, Suzuma, Kiyoshi, Burks, Deborah J, Kushner, Jake A, Suzuma, Izumi, Cahill, Christopher, Flint, Carrie L, Dow, Matthew A, Leshan, Rebecca L, King, George L, White, Morris F

“…Insulin receptor substrates (Irs-proteins) integrate signals from the insulin and insulin-like growth factor-1 (IGF1) receptors with other processes to control…”
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Transcription Factor Ets-1 Mediates Ischemia- and Vascular Endothelial Growth Factor-Dependent Retinal Neovascularization by Watanabe, Daisuke, Takagi, Hitoshi, Suzuma, Kiyoshi, Suzuma, Izumi, Oh, Hideyasu, Ohashi, Hirokazu, Kemmochi, Seiji, Uemura, Akiyoshi, Ojima, Tomonari, Suganami, Eri, Miyamoto, Noriko, Sato, Yasufumi, Honda, Yoshihito

“…Transcription factor Ets-1 has been reported to regulate angiogenesis in vascular endothelial cells. Here, we investigated a mechanism that may regulate the…”
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Estrogen Protects Against Cellular Infiltration by Reducing the Expressions of E-Selectin and IL-6 in Endotoxin-Induced Uveitis by Miyamoto, Noriko, Mandai, Michiko, Suzuma, Izumi, Suzuma, Kiyoshi, Kobayashi, Kaori, Honda, Yoshihito

“…Anterior uveitis associated with Behcet's disease and ankylosing spondylitis preferentially occurs in adult men, which may suggest the effects of sex hormones…”
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Angiopoietin-1 Attenuates H2O2-induced SEK1/JNK Phosphorylation through the Phosphatidylinositol 3-Kinase/Akt Pathway in Vascular Endothelial Cells by Murakami, Tomoaki, Takagi, Hitoshi, Suzuma, Kiyoshi, Suzuma, Izumi, Ohashi, Hirokazu, Watanabe, Daisuke, Ojima, Tomonari, Suganami, Eri, Kurimoto, Masafumi, Kaneto, Hideaki, Honda, Yoshihito, Yoshimura, Nagahisa

“…Oxidative stress activates various signal transduction pathways, including Jun N-terminal kinase (JNK) and its substrates, that induce apoptosis. We reported…”
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Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor by Hata, Y, Clermont, A, Yamauchi, T, Pierce, E A, Suzuma, I, Kagokawa, H, Yoshikawa, H, Robinson, G S, Ishibashi, T, Hashimoto, T, Umeda, F, Bursell, S E, Aiello, L P

“…Prostacyclin-stimulating factor (PSF) acts on vascular endothelial cells to stimulate the synthesis of the vasodilatory molecule prostacyclin (PGI2). We have…”
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Increased Expression of KDR/Flk-1 (VEGFR-2) in Murine Model of Ischemia-Induced Retinal Neovascularization by Suzuma, Kiyoshi, Takagi, Hitoshi, Otani, Atsushi, Suzuma, Izumi, Honda, Yoshihito

“…Although the vascular endothelial growth factor (VEGF)/VEGF receptor system plays a critical role in the pathogenesis of ischemic retinal neovascular diseases…”
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Leptin Stimulates Ischemia-Induced Retinal Neovascularization by Suganami, Eri, Takagi, Hitoshi, Ohashi, Hirokazu, Suzuma, Kiyoshi, Suzuma, Izumi, Oh, Hideyasu, Watanabe, Daisuke, Ojima, Tomonari, Suganami, Takayoshi, Fujio, Yasushi, Nakao, Kazuwa, Ogawa, Yoshihiro, Yoshimura, Nagahisa

“…Leptin Stimulates Ischemia-Induced Retinal Neovascularization Possible Role of Vascular Endothelial Growth Factor Expressed in Retinal Endothelial Cells Eri…”
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Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor—2 by Suzuma, Izumi, Hata, Yasuaki, Clermont, Allen, Pokras, Frank, Rook, Susan L., Suzuma, Kiyoshi, Feener, Edward P., Aiello, Lloyd Paul

“…Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor—2 Potential…”
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Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy by Watanabe, Daisuke, Suzuma, Kiyoshi, Suzuma, Izumi, Ohashi, Hirokazu, Ojima, Tomonari, Kurimoto, Masafumi, Murakami, Tomoaki, Kimura, Tetsushi, Takagi, Hitoshi

“…To investigate the levels of angiopoietin-2 (Ang2) and vascular endothelial growth factor (VEGF) in the vitreous fluids of patients with proliferative diabetic…”
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Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue by CHOU, Eva, SUZUMA, Izumi, KING, George L, WAY, Kerrie J, OPLAND, Darren, CLERMONT, Allen C, NARUSE, Keiko, SUZUMA, Kiyoshi, BOWLING, Nancy L, VLAHOS, Chris J, AIELLO, Lloyd Paul

“…Inadequate angiogenic response to ischemia in the myocardium of diabetic patients could result in poor collateral formation. Yet, excessive neovascularization…”
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Novel role of erythropoietin in proliferative diabetic retinopathy by Takagi, Hitoshi, Watanabe, Daisuke, Suzuma, Kiyoshi, Kurimoto, Masafumi, Suzuma, Izumi, Ohashi, Hirokazu, Ojima, Tomonari, Murakami, Tomoaki

“…Abstract Diabetic retinopathy is a leading cause of visual disturbance in adults. In proliferative diabetic retinopathy, ischemia-induced pathologic growth of…”
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Pigment Epithelium-Derived Factor Suppresses Ischemia-Induced Retinal Neovascularization and VEGF-Induced Migration and Growth by Duh, Elia J, Yang, Hoseong S, Suzuma, Izumi, Miyagi, Masaru, Youngman, Elaine, Mori, Keisuke, Katai, Miyuki, Yan, Lin, Suzuma, Kiyoshi, West, Karen, Davarya, Shekar, Tong, Patrick, Gehlbach, Peter, Pearlman, Joel, Crabb, John W, Aiello, Lloyd P, Campochiaro, Peter A, Zack, Donald J

“…To determine the effect of pigment epithelium-derived factor (PEDF) in a mouse model of ischemia-induced retinal neovascularization and on vascular endothelial…”
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Leptin stimulates ischemia-induced retinal neovascularization: Possible role of vascular endothelial growth factor expressed in retinal endothelial cells by SUGANAMI, Eri, TAKAGI, Hitoshi, NAKAO, Kazuwa, OGAWA, Yoshihiro, YOSHIMURA, Nagahisa, OHASHI, Hirokazu, SUZUMA, Kiyoshi, SUZUMA, Izumi, OH, Hideyasu, WATANABE, Daisuke, OJIMA, Tomonari, SUGANAMI, Takayoshi, FUJIO, Yasushi

“…Diabetic retinopathy is the leading cause of new blindness in adults in developed countries. Leptin, an adipocyte-derived hormone, stimulates endothelial…”
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Cyclic Stretch–Induced Reactive Oxygen Species Generation Enhances Apoptosis in Retinal Pericytes Through c-Jun NH2-Terminal Kinase Activation by Suzuma, Izumi, Murakami, Tomoaki, Suzuma, Kiyoshi, Kaneto, Hideaki, Watanabe, Daisuke, Ojima, Tomonari, Honda, Yoshihito, Takagi, Hitoshi, Yoshimura, Nagahisa

“…Hypertension is known to exacerbate diabetic complications, such as retinopathy and nephropathy. Apoptosis of retinal vascular pericytes has been well…”
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