Search Results - "Suzuki, Hiroshi"

MicroRNA Control of TGF-β Signaling by Suzuki, Hiroshi I

“…Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome changes induced by various cellular signaling cascades. MicroRNAs…”
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TGF-β Signaling in Cellular Senescence and Aging-Related Pathology by Tominaga, Kana, Suzuki, Hiroshi I

“…Aging is broadly defined as the functional decline that occurs in all body systems. The accumulation of senescent cells is considered a hallmark of aging and…”
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Systems and Synthetic microRNA Biology: From Biogenesis to Disease Pathogenesis by Matsuyama, Hironori, Suzuki, Hiroshi I

“…MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that post-transcriptionally regulate gene expression. The biogenesis of miRNAs…”
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Biomolecular condensates in cancer biology by Suzuki, Hiroshi I., Onimaru, Koh

“…Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective,…”
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Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis by Suzuki, Hiroshi I., Young, Richard A., Sharp, Phillip A.

“…Super-enhancers are an emerging subclass of regulatory regions controlling cell identity and disease genes. However, their biological function and impact on…”
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Rotavirus Replication: Gaps of Knowledge on Virus Entry and Morphogenesis by Suzuki, Hiroshi

“…In 1973, rotaviruses A (RVAs) were discovered as major causative agents of acute gastroenteritis in infants and young children worldwide. The infectious RV…”
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L2 - Evaluation of disease progression / drug effects by expanding the PK concept by Suzuki, Hiroshi

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Modulation of microRNA processing by p53 by Suzuki, Hiroshi I, Iwamoto, Takashi, Miyazono, Kohei, Yamagata, Kaoru, Sugimoto, Koichi, Kato, Shigeaki

“…MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression, involved in diverse physiological and pathological processes…”
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Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications by Toyoda, Yu, Takada, Tappei, Suzuki, Hiroshi

“…The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance protein, BCRP) has been suggested to be involved in clinical multidrug…”
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YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer by Horie, Masafumi, Saito, Akira, Ohshima, Mitsuhiro, Suzuki, Hiroshi I., Nagase, Takahide

“…Small cell lung cancer (SCLC) is a highly aggressive and metastatic malignancy that shows rapid development of chemoresistance and a high rate of recurrence…”
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Chd4 choreographs self-antigen expression for central immune tolerance by Tomofuji, Yoshihiko, Takaba, Hiroyuki, Suzuki, Hiroshi I., Benlaribi, Rayene, Martinez, Cristian David Peña, Abe, Yoshihiro, Morishita, Yasuyuki, Okamura, Tadashi, Taguchi, Akashi, Kodama, Tatsuhiko, Takayanagi, Hiroshi

“…Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous expression of tissue-restricted self-antigens in medullary thymic…”
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Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions by Suzuki, Hiroshi, Tani, Kazutoshi, Tamura, Atsushi, Tsukita, Sachiko, Fujiyoshi, Yoshinori

“…Claudins are main cell–cell adhesion molecules of tight junctions (TJs) between cells in epithelial sheets that form tight barriers that separate the apical…”
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Can molecular dynamics facilitate the design of protein–protein-interaction inhibitors? by Honma, Masashi, Suzuki, Hiroshi

“…The design of effective inhibitors of protein–protein interactions is challenging. In a new study, thermal fluctuation of protein structure was simulated to…”
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MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation by Suzuki, Hiroshi I., Arase, Mayu, Matsuyama, Hironori, Choi, Young Lim, Ueno, Toshihide, Mano, Hiroyuki, Sugimoto, Koichi, Miyazono, Kohei

“…MicroRNAs (miRNAs) are versatile regulators of gene expression and undergo complex maturation processes. However, the mechanism(s) stabilizing or reducing…”
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ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts by Yan, Minglu, Komatsu, Noriko, Muro, Ryunosuke, Huynh, Nam Cong-Nhat, Tomofuji, Yoshihiko, Okada, Yukinori, Suzuki, Hiroshi I., Takaba, Hiroyuki, Kitazawa, Riko, Kitazawa, Sohei, Pluemsakunthai, Warunee, Mitsui, Yuichi, Satoh, Takashi, Okamura, Tadashi, Nitta, Takeshi, Im, Sin-Hyeog, Kim, Chan Johng, Kollias, George, Tanaka, Sakae, Okamoto, Kazuo, Tsukasaki, Masayuki, Takayanagi, Hiroshi

“…Fibroblasts, the most abundant structural cells, exert homeostatic functions but also drive disease pathogenesis. Single-cell technologies have illuminated the…”
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RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target by Honma, Masashi, Ikebuchi, Yuki, Suzuki, Hiroshi

“…RANKL is a key molecule that bridges the bone and immune systems. RANKL stimulation activates a signaling pathway downstream of RANK, thereby determining the…”
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Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function by Ogami, Koichi, Suzuki, Hiroshi I

“…The genome is pervasively transcribed across various species, yielding numerous non-coding RNAs. As a counterbalance for pervasive transcription, various…”
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ASCL1 regulates super‐enhancer‐associated miRNAs to define molecular subtypes of small cell lung cancer by Miyakawa, Kazuko, Miyashita, Naoya, Horie, Masafumi, Terasaki, Yasuhiro, Tanaka, Hidenori, Urushiyama, Hirokazu, Fukuda, Kensuke, Okabe, Yugo, Ishii, Takashi, Kuwahara, Naomi, Suzuki, Hiroshi I., Nagase, Takahide, Saito, Akira

“…Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor with dismal prognosis. Recently, molecular subtypes of SCLC have been defined by the…”
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Network Regulation of microRNA Biogenesis and Target Interaction by Komatsu, Shintaro, Kitai, Hiroki, Suzuki, Hiroshi I

“…MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression. Canonical miRNAs are generated through the two-step DROSHA- and…”
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Chern numbers in discretized brillouin zone : Efficient method of computing (spin) hall conductances by FUKUI, Takahiro, HATSUGAI, Yasuhiro, SUZUKI, Hiroshi

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