Search Results - "Suzuki, Ayumu"

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing by Mochizuki, Kentaro, Sharif, Jafar, Shirane, Kenjiro, Uranishi, Kousuke, Bogutz, Aaron B., Janssen, Sanne M., Suzuki, Ayumu, Okuda, Akihiko, Koseki, Haruhiko, Lorincz, Matthew C.

“…Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the…”
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Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis‐related genes in mouse embryonic stem cells by Uranishi, Kousuke, Hirasaki, Masataka, Kitamura, Yuka, Mizuno, Yosuke, Nishimoto, Masazumi, Suzuki, Ayumu, Okuda, Akihiko

“…Although the physiological meaning of the high potential of mouse embryonic stem cells (ESCs) for meiotic entry is not understood, a rigid safeguarding system…”
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Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1 by Kitamura, Yuka, Uranishi, Kousuke, Hirasaki, Masataka, Nishimoto, Masazumi, Suzuki, Ayumu, Okuda, Akihiko

“…A non-canonical PRC1 (PRC1.6) prevents precocious meiotic onset. Germ cells alleviate its negative effect by reducing their amount of MAX, a component of…”
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Similarity and dissimilarity in alterations of the gene expression profile associated with inhalational anesthesia between sevoflurane and desflurane by Nogi, Takehiro, Uranishi, Kousuke, Suzuki, Ayumu, Hirasaki, Masataka, Nakamura, Tina, Kazama, Tomiei, Nagasaka, Hiroshi, Okuda, Akihiko, Mieda, Tsutomu

“…Although sevoflurane is one of the most commonly used inhalational anesthetic agents, the popularity of desflurane is increasing to a level similar to that of…”
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MAX controls meiotic entry in sexually undifferentiated germ cells by Suzuki, Ayumu, Uranishi, Kousuke, Nishimoto, Masazumi, Mizuno, Yosuke, Mizuno, Seiya, Takahashi, Satoru, Eisenman, Robert N., Okuda, Akihiko

“…Meiosis is a specialized type of cell division that occurs physiologically only in germ cells. We previously demonstrated that MYC-associated factor X (MAX)…”
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Unexpected link between MAX and meiotic onset by Okuda, Akihiko, Suzuki, Ayumu

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Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells by Suzuki, Ayumu, Hirasaki, Masataka, Hishida, Tomoaki, Wu, Jun, Okamura, Daiji, Ueda, Atsushi, Nishimoto, Masazumi, Nakachi, Yutaka, Mizuno, Yosuke, Okazaki, Yasushi, Matsui, Yasuhisa, Belmonte, Juan Carlos Izpisua, Okuda, Akihiko

“…Meiosis is a unique process that allows the generation of reproductive cells. It remains largely unknown how meiosis is initiated in germ cells and why…”
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Alternative splicing for germ cell‐specific Mga transcript can be eliminated without compromising mouse viability or fertility by Kitamura, Yuka, Suzuki, Ayumu, Uranishi, Kousuke, Nishimoto, Masazumi, Mizuno, Seiya, Takahashi, Satoru, Okuda, Akihiko

“…The stimulated by retinoic acid gene 8 (STRA8)/MEIOSIN complex and polycomb repressive complex (PRC) 1.6, a PRC1 subtype, are believed to be positive and…”
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Does MAX open up a new avenue for meiotic research? by Suzuki, Ayumu, Hirasaki, Masataka, Okuda, Akihiko

“…Meiosis is a central event of sexual reproduction. Like somatic cells, germ cells conduct mitosis to increase their cell number, but unlike somatic cells, germ…”
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Identification of the Coiled‐Coil Domain as an Essential Methyl‐CpG‐Binding Domain Protein 3 Element for Preserving Lineage Commitment Potential of Embryonic Stem Cells by Hirasaki, Masataka, Ueda, Atsushi, Asaka, Masamitsu N., Uranishi, Kousuke, Suzuki, Ayumu, Kohda, Masakazu, Mizuno, Yosuke, Okazaki, Yasushi, Nishimoto, Masazumi, Sharif, Jafar, Koseki, Haruhiko, Okuda, Akihiko

“…Embryonic stem cells (ESCs) exhibit two salient features beneficial for regenerative medicine: unlimited self‐renewal and pluripotency. Methyl‐CpG‐binding…”
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Link between embryonic stem cell pluripotency and homologous allelic pairing of Oct4 loci by Asaka, Masamitsu N., Uranishi, Kousuke, Suzuki, Ayumu, Hirasaki, Masataka, Nishimoto, Masazumi, Okuda, Akihiko

“…The Oct4 gene is a master regulator of the pluripotent properties of embryonic stem cells (ESCs). Recently, Oct4 loci were shown to frequently localize in…”
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Nuclear translocation of FGF8 and its implication to induce Sprouty2 by Suzuki, Ayumu, Harada, Hidekiyo, Nakamura, Harukazu

“…Fibroblast growth factor 8 (FGF8) functions as a local organizing signal for the tectum and cerebellum. FGF8 activates Ras‐ERK signaling pathway to induce…”
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Functional Compensation Between Myc and PI3K Signaling Supports Self‐Renewal of Embryonic Stem Cells by Hishida, Tomoaki, Nakachi, Yutaka, Mizuno, Yosuke, Katano, Miyuki, Okazaki, Yasushi, Ema, Masatsugu, Takahashi, Satoru, Hirasaki, Masataka, Suzuki, Ayumu, Ueda, Atsushi, Nishimoto, Masazumi, Hishida-Nozaki, Yuriko, Vazquez-Ferrer, Eric, Sancho-Martinez, Ignacio, Carlos Izpisua Belmonte, Juan, Okuda, Akihiko

“…c‐Myc and phosphatidylinositol 3‐OH kinase (PI3K) both participate in diverse cellular processes, including cell cycle control and tumorigenic transformation…”
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Forced Expression of Nanog or Esrrb Preserves the ESC Status in the Absence of Nucleostemin Expression by Katano, Miyuki, Ema, Masatsugu, Nakachi, Yutaka, Mizuno, Yosuke, Hirasaki, Masataka, Suzuki, Ayumu, Ueda, Atsushi, Nishimoto, Masazumi, Takahashi, Satoru, Okazaki, Yasushi, Okuda, Akihiko

“…Nucleostemin (NS) is a nucleolar GTP‐binding protein that is involved in a plethora of functions including ribosomal biogenesis and maintenance of telomere…”
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Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs by Hirasaki, Masataka, Hiraki-Kamon, Keiko, Kamon, Masayoshi, Suzuki, Ayumu, Katano, Miyuki, Nishimoto, Masazumi, Okuda, Akihiko

“…Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and…”
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Discovery of a new role for the p53 family in the onset of mesendodermal differentiation of embryonic stem cells by Okuda, Akihiko, Uranishi, Kousuke, Suzuki, Ayumu

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In vivo function and evolution of the eutherian-specific pluripotency marker UTF1 by Nishimoto, Masazumi, Katano, Miyuki, Yamagishi, Toshiyuki, Hishida, Tomoaki, Kamon, Masayoshi, Suzuki, Ayumu, Hirasaki, Masataka, Nabeshima, Yoko, Nabeshima, Yo-ichi, Katsura, Yukako, Satta, Yoko, Deakin, Janine E, Graves, Jennifer A Marshall, Kuroki, Yoko, Ono, Ryuichi, Ishino, Fumitoshi, Ema, Masatsugu, Takahashi, Satoru, Kato, Hidemasa, Okuda, Akihiko

“…Embryogenesis in placental mammals is sustained by exquisite interplay between the embryo proper and placenta. UTF1 is a developmentally regulated gene…”
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Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD by Nishimoto, Masazumi, Uranishi, Kousuke, Asaka, Masamitsu N., Suzuki, Ayumu, Mizuno, Yosuke, Hirasaki, Masataka, Okuda, Akihiko

“…YAP (also known as YAP1 or YAP65) is a transcriptional coactivator that interacts with a number of transcription factors including RUNX and TEAD and plays a…”
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Identification of Ccr4-not complex components as regulators of transition from partial to genuine induced pluripotent stem cells by Kamon, Masayoshi, Katano, Miyuki, Hiraki-Kamon, Keiko, Hishida, Tomoaki, Nakachi, Yutaka, Mizuno, Yosuke, Okazaki, Yasushi, Suzuki, Ayumu, Hirasaki, Masataka, Ueda, Atsushi, Nishimoto, Masazumi, Kato, Hidemasa, Okuda, Akihiko

“…Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by defined factors. However, substantial cell numbers subjected to iPSC induction…”
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Identification of the Coiled-Coil Domain as an Essential Mbd3 Element for Preserving Lineage Commitment Potential of Embryonic Stem Cells by Hirasaki, Masataka, Ueda, Atsushi, Asaka, Masamitsu N, Uranishi, Kousuke, Suzuki, Ayumu, Kohda, Masakazu, Mizuno, Yosuke, Okazaki, Yasushi, Nishimoto, Masazumi, Sharif, Jafar, Koseki, Haruhiko, Okuda, Akihiko

“…Embryonic stem cells (ESCs) exhibit two salient features beneficial for regenerative medicine: unlimited self-renewal and pluripotency. Methyl-CpG-binding…”
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