Search Results - "Suzich, Joann"
-
1
A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants
Published in Science translational medicine (03-05-2017)“…Prevention of respiratory syncytial virus (RSV) illness in all infants is a major public health priority. However, no vaccine is currently available to protect…”
Get more information
Journal Article -
2
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
Published in Science translational medicine (12-11-2014)“…Widespread drug resistance due to empiric use of broad-spectrum antibiotics has stimulated development of bacteria-specific strategies for prophylaxis and…”
Get more information
Journal Article -
3
Prevalence and Significance of Substitutions in the Fusion Protein of Respiratory Syncytial Virus Resulting in Neutralization Escape From Antibody MEDI8897
Published in The Journal of infectious diseases (13-07-2018)“…Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection among infants and young children. To date, no vaccine is approved…”
Get full text
Journal Article -
4
Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease
Published in mBio (17-02-2015)“…Staphylococcus aureus is a Gram-positive, commensal bacterium known to asymptomatically colonize the human skin, nares, and gastrointestinal tract. Colonized…”
Get full text
Journal Article -
5
Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae
Published in Nature communications (08-12-2017)“…Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust…”
Get full text
Journal Article -
6
Identification of broadly protective human antibodies to Pseudomonas aeruginosa exopolysaccharide Psl by phenotypic screening
Published in The Journal of experimental medicine (02-07-2012)“…Pseudomonas aeruginosa is a leading cause of hospital-associated infections in the seriously ill, and the primary agent of chronic lung infections in cystic…”
Get full text
Journal Article -
7
Attenuate Newcastle disease virus by codon modification of the glycoproteins and phosphoprotein genes
Published in Virology (New York, N.Y.) (01-02-2019)“…A codon modification strategy was used to attenuate the avian pathogenicity of an oncolytic mesogenic Newcastle disease virus (NDV) by targeting the three…”
Get full text
Journal Article -
8
A broadly neutralizing human monoclonal antibody directed against a novel conserved epitope on the influenza virus H3 hemagglutinin globular head
Published in Journal of virology (01-06-2014)“…Most neutralizing antibodies elicited during influenza virus infection or vaccination target immunodominant, variable epitopes on the globular head region of…”
Get full text
Journal Article -
9
Analysis of Respiratory Syncytial Virus Preclinical and Clinical Variants Resistant to Neutralization by Monoclonal Antibodies Palivizumab and/or Motavizumab
Published in The Journal of infectious diseases (01-03-2011)“…Background. Palivizumab is a US Food and Drug Administration—approved monoclonal antibody for the prevention of respiratory syncytial virus (RSV) lower…”
Get full text
Journal Article -
10
Infection and Propagation of Human Rhinovirus C in Human Airway Epithelial Cells
Published in Journal of Virology (01-12-2012)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
11
Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model
Published in PloS one (02-10-2013)“…An optimal host response against Staphylococcus aureus skin and soft tissue infections (SSTI) is dependent on IL-1β and IL-17 mediated abscess formation. Alpha…”
Get full text
Journal Article -
12
Natural Polymorphisms and Resistance-Associated Mutations in the Fusion Protein of Respiratory Syncytial Virus (RSV): Effects on RSV Susceptibility to Palivizumab
Published in The Journal of infectious diseases (15-02-2012)“…Specific mutations in respiratory syncytial virus (RSV) fusion protein can cause palivizumab resistance. We assessed the incidence of sequence polymorphisms…”
Get full text
Journal Article -
13
HBeAg seroconversion is associated with a more effective PD-L1 blockade during chronic hepatitis B infection
Published in JHEP reports (01-09-2019)“…Current therapies for chronic hepatitis B virus (HBV) infection control viral replication but do not eliminate the risk of progression to hepatocellular…”
Get full text
Journal Article -
14
The effect of dexamethasone on polyclonal T cell activation and redirected target cell lysis as induced by a CD19/CD3-bispecific single-chain antibody construct
Published in Cancer Immunology, Immunotherapy (01-10-2007)“…BiTE molecules comprise a new class of bispecific single-chain antibodies redirecting previously unstimulated CD8+ and CD4+ T cells for the elimination of…”
Get full text
Journal Article -
15
POTENTIAL FOR PALIVIZUMAB INTERFERENCE WITH COMMERCIALLY AVAILABLE ANTIBODY-ANTIGEN BASED RESPIRATORY SYNCYTIAL VIRUS DIAGNOSTIC ASSAYS
Published in The Pediatric infectious disease journal (01-10-2013)“…Palivizumab is a monoclonal antibody indicated for the prevention of serious lower respiratory tract disease caused by respiratory syncytial virus infection in…”
Get full text
Journal Article -
16
A Phase 1 Study of a Recombinant Viruslike Particle Vaccine against Human Papillomavirus Type 11 in Healthy Adult Volunteers
Published in The Journal of infectious diseases (15-05-2001)“…Viruslike particles (VLPs) produced from the L1 protein of several papillomaviruses have induced protection from infection after live challenge in animal…”
Get full text
Journal Article -
17
Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis
Published in The Journal of infectious diseases (15-12-2008)“…Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly…”
Get full text
Journal Article -
18
Isolation and Characterization of Monoclonal Antibodies Which Neutralize Human Metapneumovirus In Vitro and In Vivo
Published in Journal of Virology (01-08-2006)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
19
Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in the lungs of preterm lambs
Published in Respiratory research (09-08-2011)“…Factors explaining the greater susceptibility of preterm infants to severe lower respiratory infections with respiratory syncytial virus (RSV) remain poorly…”
Get full text
Journal Article -
20
Surveillance of Clinical Isolates of Respiratory Syncytial Virus for Palivizumab (Synagis)–Resistant Mutants
Published in The Journal of infectious diseases (01-09-2004)“…Premature infants and those with chronic lung disease or congenital heart disease are at high risk of severe respiratory syncytial virus (RSV) disease…”
Get full text
Journal Article