Search Results - "Suzawa, Ken"

Perioperative Management for Patients with Metabolic and Endocrine Disorders by Suzawa, Ken, Toyooka, Shinichi

“…In recent years, the number of surgical cases involving patients with comorbidities has been increasing due to the aging society. Such patients may have a…”
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Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer by Suzawa, Ken, Offin, Michael, Lu, Daniel, Kurzatkowski, Christopher, Vojnic, Morana, Smith, Roger S, Sabari, Joshua K, Tai, Huichun, Mattar, Marissa, Khodos, Inna, de Stanchina, Elisa, Rudin, Charles M, Kris, Mark G, Arcila, Maria E, Lockwood, William W, Drilon, Alexander, Ladanyi, Marc, Somwar, Romel

“…exon 14 splice site alterations that cause exon skipping at the mRNA level ( ex14) are actionable oncogenic drivers amenable to therapy with MET tyrosine…”
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Antitumor effect of afatinib, as a human epidermal growth factor receptor 2‐targeted therapy, in lung cancers harboring HER2 oncogene alterations by Suzawa, Ken, Toyooka, Shinichi, Sakaguchi, Masakiyo, Morita, Mizuki, Yamamoto, Hiromasa, Tomida, Shuta, Ohtsuka, Tomoaki, Watanabe, Mototsugu, Hashida, Shinsuke, Maki, Yuho, Soh, Junichi, Asano, Hiroaki, Tsukuda, Kazunori, Miyoshi, Shinichiro

“…Human epidermal growth factor receptor 2 (HER2) is a member of the HER family of proteins containing four receptor tyrosine kinases. It plays an important role…”
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PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer by Thu, Yin Min, Suzawa, Ken, Tomida, Shuta, Ochi, Kosuke, Tsudaka, Shimpei, Takatsu, Fumiaki, Date, Keiichi, Matsuda, Naoki, Iwata, Kazuma, Nakata, Kentaro, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Toyooka, Shinichi

“…Mechanisms underlying primary and acquired resistance to MET tyrosine kinase inhibitors (TKIs) in managing non-small cell lung cancer remain unclear. In this…”
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Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice by Nakata, Kentaro, Okazaki, Mikio, Shimizu, Dai, Suzawa, Ken, Shien, Kazuhiko, Miyoshi, Kentaroh, Otani, Shinji, Yamamoto, Hiromasa, Sugimoto, Seiichiro, Yamane, Masaomi, Ousaka, Daiki, Ohara, Toshiaki, Matsukawa, Akihiro, Nishibori, Masahiro, Toyooka, Shinichi

“…During ischemia reperfusion (IR) injury, high mobility group box 1 (HMGB1), a chromatin binding protein, is released from necrotic cells and triggers…”
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YES1 activation induces acquired resistance to neratinib in HER2‐amplified breast and lung cancers by Takeda, Tatsuaki, Yamamoto, Hiromasa, Suzawa, Ken, Tomida, Shuta, Miyauchi, Shunsaku, Araki, Kota, Nakata, Kentaro, Miura, Akihiro, Namba, Kei, Shien, Kazuhiko, Soh, Junichi, Shien, Tadahiko, Kitamura, Yoshihisa, Sendo, Toshiaki, Toyooka, Shinichi

“…Molecular‐targeted therapies directed against human epidermal growth factor receptor 2 (HER2) are evolving for various cancers. Neratinib is an irreversible…”
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Comparative mutational evaluation of multiple lung cancers by multiplex oncogene mutation analysis by Takahashi, Yuta, Shien, Kazuhiko, Tomida, Shuta, Oda, Shinsuke, Matsubara, Takehiro, Sato, Hiroki, Suzawa, Ken, Kurihara, Eisuke, Ogoshi, Yusuke, Namba, Kei, Yoshioka, Takahiro, Torigoe, Hidejiro, Yamamoto, Hiromasa, Soh, Junichi, Toyooka, Shinichi

“…In patients presenting with synchronous or metachronous multiple lung cancer (MLC), it is important to distinguish between multiple primary lung cancer (MP)…”
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Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features by Sato, Hiroki, Shien, Kazuhiko, Tomida, Shuta, Okayasu, Kazuhiro, Suzawa, Ken, Hashida, Shinsuke, Torigoe, Hidejiro, Watanabe, Mototsugu, Yamamoto, Hiromasa, Soh, Junichi, Asano, Hiroaki, Tsukuda, Kazunori, Miyoshi, Shinichiro, Toyooka, Shinichi

“…MicroRNA (miR)-200 family members (miR-200s) are frequently silenced in advanced cancer and have been implicated in the process of epithelial-to-mesenchymal…”
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Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer‐associated fibroblast by Ochi, Kosuke, Suzawa, Ken, Thu, Yin Min, Takatsu, Fumiaki, Tsudaka, Shimpei, Zhu, Yidan, Nakata, Kentaro, Takeda, Tatsuaki, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Shien, Tadahiko, Okamoto, Yoshiharu, Tomida, Shuta, Toyooka, Shinichi

“…Cancer‐associated fibroblasts (CAFs) are a major component of the tumor microenvironment that mediate resistance of cancer cells to anticancer drugs. Tranilast…”
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The prognostic impact of sarcopenia on elderly patients undergoing pulmonary resection for non-small cell lung cancer by Miura, Akihiro, Yamamoto, Hiromasa, Sato, Hiroki, Tomioka, Yasuaki, Shiotani, Toshio, Suzawa, Ken, Miyoshi, Kentaroh, Otani, Shinji, Okazaki, Mikio, Sugimoto, Seiichiro, Yamane, Masaomi, Toyooka, Shinichi

“…Purpose The number of elderly patients who undergo surgery is increasing, even though they are at a high risk due to a decreased physical strength…”
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Therapeutic strategies for afatinib‐resistant lung cancer harboring HER2 alterations by Torigoe, Hidejiro, Shien, Kazuhiko, Takeda, Tatsuaki, Yoshioka, Takahiro, Namba, Kei, Sato, Hiroki, Suzawa, Ken, Yamamoto, Hiromasa, Soh, Junichi, Sakaguchi, Masakiyo, Tomida, Shuta, Tsukuda, Kazunori, Miyoshi, Shinichiro, Toyooka, Shinichi

“…Human epidermal growth factor receptor 2 (HER2) plays an important role in the pathogenesis of various cancers. HER2 alterations have been suggested to be a…”
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Author Correction: Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array by Tomioka, Yasuaki, Sugimoto, Seiichiro, Yamamoto, Haruchika, Tomida, Shuta, Shiotani, Toshio, Tanaka, Shin, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Otani, Shinji, Yamamoto, Hiromasa, Okazaki, Mikio, Yamane, Masaomi, Toyooka, Shinichi

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Acquisition of cancer stem cell‐like properties in non‐small cell lung cancer with acquired resistance to afatinib by Hashida, Shinsuke, Yamamoto, Hiromasa, Shien, Kazuhiko, Miyoshi, Yuichiro, Ohtsuka, Tomoaki, Suzawa, Ken, Watanabe, Mototsugu, Maki, Yuho, Soh, Junichi, Asano, Hiroaki, Tsukuda, Kazunori, Miyoshi, Shinichiro, Toyooka, Shinichi

“…Afatinib is an irreversible epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor (TKI) that is known to be effective against the EGFR T790M…”
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Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array by Tomioka, Yasuaki, Sugimoto, Seiichiro, Yamamoto, Haruchika, Tomida, Shuta, Shiotani, Toshio, Tanaka, Shin, Shien, Kazuhiko, Suzawa, Ken, Miyoshi, Kentaroh, Otani, Shinji, Yamamoto, Hiromasa, Okazaki, Mikio, Yamane, Masaomi, Toyooka, Shinichi

“…Renal dysfunction is a long-term complication associated with an increased mortality after lung transplantation (LT). We investigated the association of…”
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Prognostic nutrition index affects the prognosis of patients undergoing trimodality therapy for locally advanced non-small cell lung cancer by Soh, Junichi, Suzawa, Ken, Shien, Kazuhiko, Otani, Shinji, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Katsui, Kuniaki, Yamane, Masaomi, Kiura, Katsuyuki, Kanazawa, Susumu, Toyooka, Shinichi

“…Purpose Trimodality therapy, comprised of induction chemoradiotherapy (iCRT) followed by surgery, is a highly invasive treatment option for locally advanced…”
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Chronic Lung Injury After Trimodality Therapy for Locally Advanced Non-Small Cell Lung Cancer by Soh, Junichi, Sugimoto, Seiichiro, Namba, Kei, Miura, Akihiro, Shiotani, Toshio, Yamamoto, Haruchika, Suzawa, Ken, Shien, Kazuhiko, Yamamoto, Hiromasa, Okazaki, Mikio, Katsui, Kuniaki, Yamane, Masaomi, Kiura, Katsuyuki, Kanazawa, Susumu, Toyooka, Shinichi

“…Trimodality therapy is a treatment option for patients with locally advanced non-small cell lung cancer (LA-NSCLC). Thoracic radiation has both early…”
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Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR by Torigoe, Hidejiro, Yamamoto, Hiromasa, Sakaguchi, Masakiyo, Youyi, Chen, Namba, Kei, Sato, Hiroki, Shien, Kazuhiko, Soh, Junichi, Suzawa, Ken, Tomida, Shuta, Tsukuda, Kazunori, Miyoshi, Shinichiro, Toyooka, Shinichi

“…The expression of LRIG1 was lower in NSCLC cells than in non-malignant cells. Transfection of LRIG1 into NSCLC cells harboring mutant EGFR led to decrease in…”
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The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas by Yamamoto, Hiromasa, Namba, Kei, Yamamoto, Haruchika, Toji, Tomohiro, Soh, Junichi, Shien, Kazuhiko, Suzawa, Ken, Kurosaki, Takeshi, Otani, Shinji, Okazaki, Mikio, Sugimoto, Seiichiro, Yamane, Masaomi, Takahashi, Katsuhito, Kunisada, Toshiyuki, Oto, Takahiro, Toyooka, Shinichi

“…Purpose Sarcomas are among the most refractory malignant tumors and often recur as pulmonary metastasis. Although the presence of a high…”
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Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation by Shiotani, Toshio, Sugimoto, Seiichiro, Yamamoto, Haruchika, Miyoshi, Kentaroh, Otani, Shinji, Suzawa, Ken, Yamamoto, Hiromasa, Okazaki, Mikio, Yamane, Masaomi, Toyooka, Shinichi

“…Purpose Decreased irisin levels may be associated with the development of emphysema. Similarly, emphysematous changes may develop in patients with chronic lung…”
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Completely Video-assisted Thoracoscopic Lobectomy for Congenital Lobar Emphysema in a Young Adult by Ryuko, Tsuyoshi, Yamamoto, Hiromasa, Sugimoto, Seiichiro, Suzawa, Ken, Miyoshi, Kentaroh, Otani, Shinji, Okazaki, Mikio, Yamane, Masaomi, Toyooka, Shinichi

“…Congenital lobar emphysema (CLE) is defined as the hyperinflation of pulmonary lobes due to obstruction of the flow of air via a known or unknown etiology,…”
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