Search Results - "Suzanne Craft"

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches by Kellar, Derek, Craft, Suzanne

“…Insulin is a peptide secreted by the pancreas and plays an important role in the regulation of glucose metabolism in peripheral tissues. Although the role of…”
Get full text

Insulin resistance and AD—extending the translational path by Craft, Suzanne

“…Two recent studies have carefully characterized amyloid-related brain insulin resistance in animal models of, and patients with, Alzheimer disease (AD). The…”
Get full text

Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment by Craft, Suzanne

“…Insulin modulates cognition and other aspects of normal brain function. Insulin resistance is characterized by chronic peripheral insulin elevations, and it is…”
Get more information

Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages by Neth, Bryan J, Craft, Suzanne

“…Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced by brain glucose hypometabolism that can be observed potentially…”
Get full text

Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation by Craft, Suzanne

“…Insulin plays an important role in memory and other aspects of brain function. The insulin resistance syndrome, characterized by chronic peripheral insulin…”
Get full text

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums by Arnold, Steven E., Arvanitakis, Zoe, Macauley-Rambach, Shannon L., Koenig, Aaron M., Wang, Hoau-Yan, Ahima, Rexford S., Craft, Suzanne, Gandy, Sam, Buettner, Christoph, Stoeckel, Luke E., Holtzman, David M., Nathan, David M.

“…Key Points The molecular signalling pathways through which insulin exerts its actions in the body also mediate its roles in synaptic neurotransmission,…”
Get full text

Diabetic Microvascular Disease: An Endocrine Society Scientific Statement by Barrett, Eugene J, Liu, Zhenqi, Khamaisi, Mogher, King, George L, Klein, Ronald, Klein, Barbara E K, Hughes, Timothy M, Craft, Suzanne, Freedman, Barry I, Bowden, Donald W, Vinik, Aaron I, Casellini, Carolina M

“…Abstract Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of…”
Get full text

Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial by Craft, Suzanne, Claxton, Amy, Baker, Laura D, Hanson, Angela J, Cholerton, Brenna, Trittschuh, Emily H, Dahl, Deborah, Caulder, Erin, Neth, Bryan, Montine, Thomas J, Jung, Youngkyoo, Maldjian, Joseph, Whitlow, Christopher, Friedman, Seth

“…Long acting insulin detemir administered intranasally for three weeks enhanced memory for adults with Alzheimer's disease dementia (AD) or amnestic mild…”
Get more information

Enhancement of Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes by NOVAK, Vera, MILBERG, William, YING HAO, MUNSHI, Medha, NOVAK, Peter, GALICA, Andrew, MANOR, Bradley, ROBERSON, Paula, CRAFT, Suzanne, ABDULJALIL, Amir

“…To determine acute effects of intranasal insulin on regional cerebral perfusion and cognition in older adults with type 2 diabetes mellitus (DM). This was a…”
Get full text

Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study by Nagpal, Ravinder, Neth, Bryan J., Wang, Shaohua, Mishra, Sidharth P., Craft, Suzanne, Yadav, Hariom

“…Recently, we reported that patients with mild cognitive impairment (MCI) harbor specific signature of bacteria in their gut and that a modified Mediterranean…”
Get full text

Intranasal Treatment of Central Nervous System Dysfunction in Humans by Chapman, Colin D., Frey, William H., Craft, Suzanne, Danielyan, Lusine, Hallschmid, Manfred, Schiöth, Helgi B., Benedict, Christian

“…ABSTRACT One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For…”
Get full text

Targeting immunometabolic pathways for combination therapy in Alzheimer's disease by Erichsen, Jennifer, Craft, Suzanne

“…The recent success of disease‐modifying anti‐amyloid monoclonal antibodies in slowing Alzheimer's disease (AD) symptoms has been an exciting step forward for…”
Get full text

Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces by Nagpal, Ravinder, Wang, Shaohua, Solberg Woods, Leah C, Seshie, Osborne, Chung, Stephanie T, Shively, Carol A, Register, Thomas C, Craft, Suzanne, McClain, Donald A, Yadav, Hariom

“…Gut microbiome plays a fundamental role in several aspects of host health and diseases. There has been an exponential surge in the use of animal models that…”
Get full text

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease by Turner, R Scott, Thomas, Ronald G, Craft, Suzanne, van Dyck, Christopher H, Mintzer, Jacobo, Reynolds, Brigid A, Brewer, James B, Rissman, Robert A, Raman, Rema, Aisen, Paul S

“…OBJECTIVE:A randomized, placebo-controlled, double-blind, multicenter 52-week phase 2 trial of resveratrol in individuals with mild to moderate Alzheimer…”
Get full text

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence by Freiherr, Jessica, Hallschmid, Manfred, Frey, William H., Brünner, Yvonne F., Chapman, Colin D., Hölscher, Christian, Craft, Suzanne, De Felice, Fernanda G., Benedict, Christian

“…Research in animals and humans has associated Alzheimer’s disease (AD) with decreased cerebrospinal fluid levels of insulin in combination with decreased…”
Get full text

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease by Snyder, Heather M, Corriveau, Roderick A, Craft, Suzanne, Faber, James E, Greenberg, Steven M, Knopman, David, Lamb, Bruce T, Montine, Thomas J, Nedergaard, Maiken, Schaffer, Chris B, Schneider, Julie A, Wellington, Cheryl, Wilcock, Donna M, Zipfel, Gregory J, Zlokovic, Berislav, Bain, Lisa J, Bosetti, Francesca, Galis, Zorina S, Koroshetz, Walter, Carrillo, Maria C

“…Abstract Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease…”
Get full text

Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative by Snyder, Heather M, Asthana, Sanjay, Bain, Lisa, Brinton, Roberta, Craft, Suzanne, Dubal, Dena B, Espeland, Mark A, Gatz, Margaret, Mielke, Michelle M, Raber, Jacob, Rapp, Peter R, Yaffe, Kristine, Carrillo, Maria C

“…Abstract More than 5 million Americans are living with Alzheimer's disease (AD) today, and nearly two-thirds of Americans with AD are women. This sex…”
Get full text

Intranasal insulin modulates cerebrospinal fluid markers of neuroinflammation in mild cognitive impairment and Alzheimer’s disease: a randomized trial by Kellar, Derek, Register, Thomas, Lockhart, Samuel N., Aisen, Paul, Raman, Rema, Rissman, Robert A., Brewer, James, Craft, Suzanne

“…Intranasal insulin (INI) has shown promise as a treatment for Alzheimer’s disease (AD) in pilot clinical trials. In a recent phase 2 trial, participants with…”
Get full text

Insulin resistance predicts brain amyloid deposition in late middle-aged adults by Willette, Auriel A, Johnson, Sterling C, Birdsill, Alex C, Sager, Mark A, Christian, Bradley, Baker, Laura D, Craft, Suzanne, Oh, Jennifer, Statz, Eric, Hermann, Bruce P, Jonaitis, Erin M, Koscik, Rebecca L, La Rue, Asenath, Asthana, Sanjay, Bendlin, Barbara B

“…Abstract Background Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased…”
Get full text

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease by Sperling, Reisa A, Aisen, Paul S, Beckett, Laurel A, Bennett, David A, Craft, Suzanne, Fagan, Anne M, Iwatsubo, Takeshi, Jack, Clifford R, Kaye, Jeffrey, Montine, Thomas J, Park, Denise C, Reiman, Eric M, Rowe, Christopher C, Siemers, Eric, Stern, Yaakov, Yaffe, Kristine, Carrillo, Maria C, Thies, Bill, Morrison-Bogorad, Marcelle, Wagster, Molly V, Phelps, Creighton H

“…Abstract The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long “preclinical”…”
Get full text