Search Results - "Sutton, Steven C"

Gut Microbiome: Profound Implications for Diet and Disease by Hills, Jr, Ronald D, Pontefract, Benjamin A, Mishcon, Hillary R, Black, Cody A, Sutton, Steven C, Theberge, Cory R

“…The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to…”
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Role of Physiological Intestinal Water in Oral Absorption by Sutton, Steven C.

“…Water volume has impact when the compound has low aqueous solubility. For example, the absorption of compounds with a Biopharmaceutics Classification System…”
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Effects of Digestion, Cell Culture Media, and Mucous on the Physical Properties, Cellular Effects, and Translocation of Polystyrene and Polymethacrylate Nanoparticles by Jabor, Zainab, Sutton, Steven C

“…The discovery of plastic and metal nanoparticles in organisms, foods, and beverages has generated numerous studies on the effects of these particles on the…”
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Fed and fasted gastric pH and gastric residence time in conscious beagle dogs by Sagawa, Kazuko, Li, Fasheng, Liese, Ryan, Sutton, Steven C

“…The gastric pH values are controversial in the literature. Some suggest the dog gastric pH is higher than human and dog gastric pH after fed with particular…”
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The impact of gastric pH, volume, and emptying on the food effect of ziprasidone oral absorption by Sutton, Steven C, Nause, Richard, Gandelman, Kuan

“…ABSTRACT In a recent food effect clinical study, the authors concluded that a meal consisting of ≥500 kcal, regardless of fat content, produced the maximal…”
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The use of gastrointestinal intubation studies for controlled release development by Sutton, Steven C.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Regional gastrointestinal absorption and toleration studies to support controlled release (CR) development have been…”
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Dog colonoscopy model for predicting human colon absorption by SUTTON, Steven C, EVANS, Loreen A, FORTNER, Jay H, MCCARTHY, Jennifer M, SWEENEY, Kathy

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Companion animal physiology and dosage form performance by Sutton, Steven C

“…Among the most critical parameters for any drug candidate are tolerability, dose, solubility and permeability. For controlled release formulations,…”
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Solid Nanocrystalline Dispersions of Ziprasidone with Enhanced Bioavailability in the Fasted State by Thombre, Avinash G, Caldwell, W. Brett, Friesen, Dwayne T, McCray, Scott B, Sutton, Steven C

“…Reducing the absorption difference between fed and fasted states is an important goal in the development of pharmaceutical dosage forms. The goal of this work…”
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In vitro models for selection of development candidates. Permeability studies to define mechanisms of absorption enhancement by LeCluyse, Edward L., Sutton, Steven C.

“…Considerable attention has been given to alternative strategies for improving the absorption of peptides and hydrophilic drugs across the intestinal…”
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A statistical method for the determination of absorption rate constant estimated using the rat single pass intestinal perfusion model and multiple linear regression by Sutton, Steven C, Rinaldi, M T S, McCarthy, J M, Vukovinsky, K E

“…The guide "Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Dosage Forms Containing Certain Active Moieties/Active…”
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Dog colonoscopy model for predicting human colon absorption by Sutton, Steven C, Evans, Loreen A, Fortner, Jay H, McCarthy, Jennifer M, Sweeney, Kathy

“…This study was conducted to develop and validate a dog colon model that predicts colon permeability in humans. The following compounds were studied: Class 1…”
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An automated process for building reliable and optimal in vitro/in vivo correlation models based on Monte Carlo simulations by Sutton, Steven C, Hu, Mingxiu

“…Many mathematical models have been proposed for establishing an in vitro/in vivo correlation (IVIVC). The traditional IVIVC model building process consists of…”
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A computational model for particle size influence on drug absorption during controlled-release colonic delivery by Waterman, Kenneth C., Sutton, Steven C.

“…The effect of particle size on the percent drug absorbed is computationally modeled for controlled-release dosage forms that deliver drug particles to the…”
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Comparison of the gravimetric, phenol red, and 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model by Sutton, S C, Rinaldi, M T, Vukovinsky, K E

“…This study was undertaken to determine whether the gravimetric method provided an accurate measure of water flux correction and to compare the gravimetric…”
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Simultaneous in vitro measurement of intestinal tissue permeability and transepithelial electrical resistance (TEER) using sweetana-grass diffusion cells by SUTTON, S. C, FORBES, A. E, CARGILL, R, HOCHMAN, J. H, LECLUYSE, E. L

“…A simple modification of the commercially available Sweetana-Grass (S-G) side-by-side diffusion cells, allowing the simultaneous measurement of tissue…”
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Companion animal physiology and dosage form performance: Veterinary drug delivery: Part VI by SUTTON, Steven C

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Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications. By Kiyohiko Sugano by Sutton, Steven C.

“…Wiley, Hoboken 2012. 520 pp., hardcover, $125.00.—ISBN 978‐1‐1180‐2868‐1…”
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Absorption of magnesium from orally administered magnesium sulfate in man by Morris, M E, LeRoy, S, Sutton, S C

“…The use of magnesium sulfate (Epsom salt) as a cathartic in patients with impaired renal function can lead to severe toxicity due to hypermagnesemia. Although…”
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Effect of dosage regimen on the development of tolerance to nitroglycerin in rats by Sutton, S C, Fung, H L

“…The recent introduction of several sustained delivery systems of nitroglycerin (NTG) raises the question whether the mode of drug input (e.g., sustained versus…”
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