Search Results - "Sutton, Margie N"

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters by Sutton, Margie N., Lu, Zhen, Li, Yao-Cheng, Zhou, Yong, Huang, Tao, Reger, Albert S., Hurwitz, Amy M., Palzkill, Timothy, Logsdon, Craig, Liang, Xiaowen, Gray, Joe W., Nan, Xiaolin, Hancock, John, Wahl, Geoffrey M., Bast, Robert C.

“…Oncogenic RAS mutations drive cancers at many sites. Recent reports suggest that RAS dimerization, multimerization, and clustering correlate strongly with…”
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Directed evolution of cyclic peptides for inhibition of autophagy by Gray, Joshua P, Uddin, Md. Nasir, Chaudhari, Rajan, Sutton, Margie N, Yang, Hailing, Rask, Philip, Locke, Hannah, Engel, Brian J, Batistatou, Nefeli, Wang, Jing, Grindel, Brian J, Bhattacharya, Pratip, Gammon, Seth T, Zhang, Shuxing, Piwnica-Worms, David, Kritzer, Joshua A, Lu, Zhen, Bast, Robert C, Millward, Steven W

“…In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy…”
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Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders by Li, Yao-Cheng, 李燿成, Lytle, Nikki K., Gammon, Seth T., Wang, Luke, Hayes, Tikvah K., Sutton, Margie N., Bast, Robert C., Der, Channing J., Piwnica-Worms, David, McCormick, Frank, Wahl, Geoffrey M.

“…HRAS, NRAS, and KRAS4A/KRAS4B comprise the RAS family of small GTPases that regulate signaling pathways controlling cell proliferation, differentiation, and…”
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Dimerization of the 4Ig isoform of B7-H3 in tumor cells mediates enhanced proliferation and tumorigenic signaling by Sutton, Margie N., Glazer, Sarah E., Muzzioli, Riccardo, Yang, Ping, Gammon, Seth T., Piwnica-Worms, David

“…B7-H3 ( CD276 ) has two isoforms (2Ig and 4Ig), no confirmed cognate receptor, and physiological functions that remain elusive. While differentially expressed…”
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Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging by Engel, Brian J, Paolillo, Vincenzo, Uddin, Md Nasir, Gonzales, Kristyn A, McGinnis, Kathryn M, Sutton, Margie N, Patnana, Madhavi, Grindel, Brian J, Gores, Gregory J, Piwnica-Worms, David, Beretta, Laura, Pisaneschi, Federica, Gammon, Seth T, Millward, Steven W

“…The worldwide incidence of hepatocellular carcinoma (HCC) continues to rise, in part due to poor diet, limited exercise, and alcohol abuse. Numerous studies…”
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DIRAS3: An Imprinted Tumor Suppressor Gene that Regulates RAS and PI3K-driven Cancer Growth, Motility, Autophagy, and Tumor Dormancy by Bildik, Gamze, Liang, Xiaowen, Sutton, Margie N, Bast, Jr, Robert C, Lu, Zhen

“…DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kDa GTPase with 60% amino acid homology to RAS, but with a distinctive 34 amino acid N-terminal…”
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Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner by Rao, Yi, Gammon, Seth T., Sutton, Margie N., Zacharias, Niki M., Bhattacharya, Pratip, Piwnica-Worms, David

“…Cellular pyruvate is an essential metabolite at the crossroads of glycolysis and oxidative phosphorylation, capable of supporting fermentative glycolysis by…”
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The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3‐induced dormant ovarian cancer xenografts by Mao, Weiqun, Peters, Haley L., Sutton, Margie N., Orozco, Aaron F., Pang, Lan, Yang, Hailing, Lu, Zhen, Bast, Robert C.

“…Background Re‐expression of the imprinted tumor suppressor gene DIRAS family GTPase 3 (DIRAS3) (aplysia ras homology member I [ARHI]) induces autophagy and…”
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RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells by Sutton, Margie N., Yang, Hailing, Huang, Gilbert Y., Fu, Caroline, Pontikos, Michael, Wang, Yan, Mao, Weiqun, Pang, Lan, Yang, Maojie, Liu, Jinsong, Parker-Thornburg, Jan, Lu, Zhen, Bast, Robert C.

“…Among the 3 GTPases in the DIRAS family, DIRAS3/ARHI is the best characterized. DIRAS3 is an imprinted tumor suppressor gene that encodes a 26-kDa GTPase that…”
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RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging by Sutton, Margie N., Gammon, Seth T., Muzzioli, Riccardo, Pisaneschi, Federica, Radaram, Bhasker, Yang, Ping, Piwnica-Worms, David

“…Purpose Macropinocytosis serves as a highly conserved endocytotic process that has recently been shown as a critical mechanism by which RAS-transformed cells…”
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Amino Acid Deprivation-Induced Autophagy Requires Upregulation of DIRAS3 through Reduction of E2F1 and E2F4 Transcriptional Repression by Sutton, Margie N, Huang, Gilbert Y, Zhou, Jinhua, Mao, Weiqun, Langley, Robert, Lu, Zhen, Bast, Jr, Robert C

“…Failure to cure ovarian cancer relates to the persistence of dormant, drug-resistant cancer cells following surgery and chemotherapy. "Second look" surgery can…”
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Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB by Morgado, Micaela, Sutton, Margie N, Simmons, Mary, Warren, Curtis R, Lu, Zhen, Constantinou, Pamela E, Liu, Jinsong, Francis, Lewis L W, Conlan, R Steven, Bast, Jr, Robert C, Carson, Daniel D

“…Transmembrane mucins (TMs) are restricted to the apical surface of normal epithelia. In cancer, TMs not only are over-expressed, but also lose polarized…”
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Complementary Longitudinal Serum Biomarkers to CA125 for Early Detection of Ovarian Cancer by Simmons, Archana R, Fourkala, Evangelia Ourania, Gentry-Maharaj, Aleksandra, Ryan, Andy, Sutton, Margie N, Baggerly, Keith, Zheng, Hui, Lu, Karen H, Jacobs, Ian, Skates, Steven, Menon, Usha, Bast, Jr, Robert C

“…Early detection of ovarian cancer has the potential to impact mortality. A multimodal screening strategy where rising CA125 values over time, analyzed with the…”
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Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models by Ornelas, Argentina, McCullough, Christopher R, Lu, Zhen, Zacharias, Niki M, Kelderhouse, Lindsay E, Gray, Joshua, Yang, Hailing, Engel, Brian J, Wang, Yan, Mao, Weiqun, Sutton, Margie N, Bhattacharya, Pratip K, Bast, Jr, Robert C, Millward, Steven W

“…Autophagy is a bulk catabolic process that modulates tumorigenesis, therapeutic resistance, and dormancy. The tumor suppressor ARHI (DIRAS3) is a potent…”
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Abstract 3659: DIRAS1 and DIRAS2 are novel ovarian cancer tumor suppressors that regulate cell growth, motility and autophagy by Sutton, Margie N., Lu, Zhen, Yang, Hailing, Huang, Gilbert, Wang, Yan, Mao, Weiqun, Bast, Robert C.

“…DIRAS3 (also known as ARHI; Aplasia Ras Homolog Member I) is a potent tumor suppressor that has been well characterized for its role in ovarian cancer and…”
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DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1 by Sutton, Margie N, Huang, Gilbert Y, Liang, Xiaowen, Sharma, Rajesh, Reger, Albert S, Mao, Weiqun, Pang, Lan, Rask, Philip J, Lee, Kwangkook, Gray, Joshua P, Hurwitz, Amy M, Palzkill, Timothy, Millward, Steven W, Kim, Choel, Lu, Zhen, Bast, Jr, Robert C

“…Autophagy can protect cancer cells from acute starvation and enhance resistance to chemotherapy. Previously, we reported that autophagy plays a critical role…”
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Abstract 2482A: ARHI (DIRAS3) downregulates Ras-MAPK signaling and inhibits transformation of NIH3T3 cells through direct interaction with GTP-bound Ras by Sutton, Margie N.

“…Somatic mutation of Ras was the first genetic alteration documented to drive human oncogenesis. Activating mutations of H-Ras, N-Ras, or K-Ras are associated…”
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Abstract A43: DIRAS1 and DIRAS2 are tumor suppressor candidates that inhibit cell growth, motility, and proliferation while regulating autophagy in ovarian cancer by Sutton, Margie N., Lu, Zhen, Bast, Robert C.

“…Among the three members of the DIRAS family, DIRAS3 (also known as Aplasia Ras Homolog Member I; ARHI) has been best characterized. DIRAS3 is a maternally…”
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The Role of VEGF, IL-8 and IGF in Sustaining Autophagic DIRAS3-induced Dormant Ovarian Cancer Xenografts by Mao, Weiqun, Peters, Haley L., Sutton, Margie N., Orozco, Aaron F., Pang, Lan, Yang, Hailing, Lu, Zhen, Bast, Robert C.

“…Over the last 3 decades, despite improvement in 5-year survival for patients with ovarian cancer, the overall cure rate of approximately 35% has not changed…”
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Abstract 1669: DIRAS family members inhibit cell growth and proliferation while inducing autophagy in human ovarian cancer cells by Sutton, Margie N., Lu, Zhen, Bast, Robert C.

“…Among the three members of the DIRAS family, DIRAS3 (also known as AplasiaRasHomolog Member I; ARHI) has been best characterized. ARHI is a maternally…”
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