Search Results - "Sutton, Keith A"

The flagellar protein Enkurin is required for mouse sperm motility and for transport through the female reproductive tract by Jungnickel, Melissa K, Sutton, Keith A, Baker, Mark A, Cohen, Michael G, Sanderson, Michael J, Florman, Harvey M

“…Enkurin was identified initially in mouse sperm where it was suggested to act as an intracellular adaptor protein linking membrane calcium influx to…”
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polycystin-1 controls postcopulatory reproductive selection in mice by Sutton, Keith A, Jungnickel, Melissa K, Florman, Harvey M

“…Pkdrej, a member of the polycystin-1 gene family, is expressed only in the male germ line. Male mice that are homozygous for a targeted mutation in the Pkdrej…”
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Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation1 by Goodson, Summer G, Qiu, Yunping, Sutton, Keith A, Xie, Guoxiang, Jia, Wei, O'Brien, Deborah A

“…Although substantial evidence exists that sperm ATP production via glycolysis is required for mammalian sperm function and male fertility, conflicting reports…”
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Functional characterization of PKDREJ, a male germ cell-restricted polycystin by Sutton, Keith A., Jungnickel, Melissa K., Ward, Christopher J., Harris, Peter C., Florman, Harvey M.

“…Polycystin‐1 regulates a number of cellular processes through the formation of complexes with the polycystin‐2 ion channel or with other signal transduction…”
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What can we learn about fertilization from cystic fibrosis? by Florman, Harvey M, Jungnickel, Melissa K, Sutton, Keith A

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Metabolic Substrates Exhibit Differential Effects on Functional Parameters of Mouse Sperm Capacitation by GOODSON, Summer G, YUNPING QIU, SUTTON, Keith A, GUOXIANG XIE, WEI JIA, O'BRIEN, Deborah A

“…Although substantial evidence exists that sperm ATP production via glycolysis is required for mammalian sperm function and male fertility, conflicting reports…”
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Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF by Brown, Sean G., Publicover, Stephen J., Mansell, Steven A., Lishko, Polina V., Williams, Hannah L., Ramalingam, Mythili, Wilson, Stuart M., Barratt, Christopher L.R., Sutton, Keith A., Da Silva, Sarah Martins

“…Abstract STUDY QUESTION Are significant abnormalities in outward (K+) conductance and resting membrane potential (Vm) present in the spermatozoa of patients…”
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Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa by Williams, Hannah L., Mansell, Steven, Alasmari, Wardah, Brown, Sean G., Wilson, Stuart M., Sutton, Keith A., Miller, Melissa R., Lishko, Polina V., Barratt, Christopher L.R., Publicover, Steven J., Martins da Silva, Sarah

“…STUDY QUESTION Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their…”
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Regulating the acrosome reaction by Florman, Harvey M, Jungnickel, Melissa K, Sutton, Keith A

“…The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in…”
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Phosphoinositide-dependent pathways in mouse sperm are regulated by egg ZP3 and drive the acrosome reaction by Jungnickel, Melissa K., Sutton, Keith A., Wang, Yanli, Florman, Harvey M.

“…Sperm of many animals must complete an exocytotic event, the acrosome reaction, in order to fuse with eggs. In mammals, acrosome reactions are triggered during…”
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Sexual selection and the adaptive evolution of PKDREJ protein in primates and rodents by Vicens, Alberto, Gómez Montoto, Laura, Couso-Ferrer, Francisco, Sutton, Keith A, Roldan, Eduardo R S

“…PKDREJ is a testis-specific protein thought to be located on the sperm surface. Functional studies in the mouse revealed that loss of PKDREJ has effects on…”
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Shedding Light on Sperm pHertility by Florman, Harvey M., Jungnickel, Melissa K., Sutton, Keith A.

“…The acquisition of fertilization capacity by sperm is regulated by intracellular pH (pH i), but the transport pathways that regulate pH i are not well…”
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Rapid evolution of a homeodomain: evidence for positive selection by Sutton, K A, Wilkinson, M F

“…One often-noted feature of homeobox genes is the conservation of the homeodomain among orthologous genes from distantly related species. This sequence…”
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Evolution of the voltage sensor domain of the voltage-sensitive phosphoinositide phosphatase VSP/TPTE suggests a role as a proton channel in eutherian mammals by Sutton, Keith A, Jungnickel, Melissa K, Jovine, Luca, Florman, Harvey M

“…The voltage-sensitive phosphoinositide phosphatases provide a mechanism to couple changes in the transmembrane electrical potential to intracellular signal…”
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Enkurin is a novel calmodulin and TRPC channel binding protein in sperm by Sutton, Keith A., Jungnickel, Melissa K., Wang, Yanli, Cullen, Kay, Lambert, Stephen, Florman, Harvey M.

“…The TRPC cation channel family has been implicated in receptor- or phospholipase C (PLC)-mediated Ca2+ entry into animal cells. These channels are present in…”
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"Know thyself" by Sutton, Keith A., Jungnickel, Melissa K.

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Coup d'oeil of sperm by Florman, Harvey M., Cao, Wenlei, Jungnickel, Melissa K., Sutton, Keith A., Tsai, Pei-Shiue

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In the Beginning: Lessons from Fertilization in Mice and Worms by Jungnickel, Melissa K, Sutton, Keith A, Florman, Harvey M

“…Sexual reproduction proceeds by fertilization; formation of new individuals by the union of haploid gametes. Recent reports in Cell and in Developmental Cell…”
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How to attract a sperm by Kirkman-Brown, Jackson C, Sutton, Keith A, Florman, Harvey M

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Of fertility, cystic fibrosis and the bicarbonate ion by Sutton, Keith A, Jungnickel, Melissa K, Florman, Harvey M

“…Mammalian sperm require activation within the female reproductive tract to fertilize eggs, and bicarbonate is essential for this process in vitro. A recent…”
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