Search Results - "Sutton, Henry J."

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response by McNamara, Hayley A., Idris, Azza H., Sutton, Henry J., Vistein, Rachel, Flynn, Barbara J., Cai, Yeping, Wiehe, Kevin, Lyke, Kirsten E., Chatterjee, Deepyan, KC, Natasha, Chakravarty, Sumana, Lee Sim, B. Kim, Hoffman, Stephen L., Bonsignori, Mattia, Seder, Robert A., Cockburn, Ian A.

“…Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the…”
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Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans by Sutton, Henry J., Aye, Racheal, Idris, Azza H., Vistein, Rachel, Nduati, Eunice, Kai, Oscar, Mwacharo, Jedida, Li, Xi, Gao, Xin, Andrews, T. Daniel, Koutsakos, Marios, Nguyen, Thi H.O., Nekrasov, Maxim, Milburn, Peter, Eltahla, Auda, Berry, Andrea A., KC, Natasha, Chakravarty, Sumana, Sim, B. Kim Lee, Wheatley, Adam K., Kent, Stephen J., Hoffman, Stephen L., Lyke, Kirsten E., Bejon, Philip, Luciani, Fabio, Kedzierska, Katherine, Seder, Robert A., Ndungu, Francis M., Cockburn, Ian A.

“…The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total…”
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Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes by Chatterjee, Deepyan, Lewis, Fiona J., Sutton, Henry J., Kaczmarski, Joe A., Gao, Xin, Cai, Yeping, McNamara, Hayley A., Jackson, Colin J., Cockburn, Ian A.

“…Antibodies targeting the NANP/NVDP repeat domain of the Plasmodium falciparum circumsporozoite protein (CSPRepeat) can protect against malaria. However, it has…”
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T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein by Fisher, Camilla R, Sutton, Henry J, Kaczmarski, Joe A, McNamara, Hayley A, Clifton, Ben, Mitchell, Joshua, Cai, Yeping, Dups, Johanna N, D'Arcy, Nicholas J, Singh, Mandeep, Chuah, Aaron, Peat, Thomas S, Jackson, Colin J, Cockburn, Ian A

“…The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing…”
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A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice by Boast, Brigette, Miosge, Lisa A, Kuehn, Hye Sun, Cho, Vicky, Athanasopoulos, Vicki, McNamara, Hayley A, Sontani, Yovina, Mei, Yan, Howard, Debbie, Sutton, Henry J, Omari, Sofia A, Yu, Zhijia, Nasreen, Mariam, Andrews, T Daniel, Cockburn, Ian A, Goodnow, Christopher C, Rosenzweig, Sergio D, Enders, Anselm

“…IKZF1 (IKAROS) is essential for normal lymphopoiesis in both humans and mice. Previous mouse models have demonstrated the dual role for IKZF1 in both B and T…”
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Long-primed germinal centres with enduring affinity maturation and clonal migration by Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torres, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., Crotty, Shane

“…Germinal centres are the engines of antibody evolution. Here, using human immunodeficiency virus (HIV) Env protein immunogen priming in rhesus monkeys followed…”
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Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation by Sutton, Henry J, Gao, Xin, Kelly, Hannah G, Parker, Brian J, Lofgren, Mariah, Dacon, Cherrelle, Chatterjee, Deepyan, Seder, Robert A, Tan, Joshua, Idris, Azza H, Neeman, Teresa, Cockburn, Ian A

“…Long-lived plasma cells (PCs) secrete antibodies that can provide sustained immunity against infection. High-affinity cells are proposed to preferentially…”
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Immunological memory diversity in the human upper airway by Ramirez, Sydney I., Faraji, Farhoud, Hills, L. Benjamin, Lopez, Paul G., Goodwin, Benjamin, Stacey, Hannah D., Sutton, Henry J., Hastie, Kathryn M., Saphire, Erica Ollmann, Kim, Hyun Jik, Mashoof, Sara, Yan, Carol H., DeConde, Adam S., Levi, Gina, Crotty, Shane

“…The upper airway is an important site of infection, but immune memory in the human upper airway is poorly understood, with implications for COVID-19 and many…”
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Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype by Aye, Racheal, Sutton, Henry J., Nduati, Eunice W., Kai, Oscar, Mwacharo, Jedida, Musyoki, Jennifer, Otieno, Edward, Wambua, Juliana, Bejon, Philip, Cockburn, Ian A., Ndungu, Francis M.

“…Atypical memory B cells (aMBCs) are found in elevated numbers in individuals exposed to malaria. A key question is whether malaria induces aMBCs as a result of…”
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Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates by Steichen, Jon M, Phung, Ivy, Salcedo, Eugenia, Ozorowski, Gabriel, Willis, Jordan R, Baboo, Sabyasachi, Liguori, Alessia, Cottrell, Christopher A, Torres, Jonathan L, Madden, Patrick J, Ma, Krystal M, Sutton, Henry J, Lee, Jeong Hyun, Kalyuzhniy, Oleksandr, Allen, Joel D, Rodriguez, Oscar L, Adachi, Yumiko, Mullen, Tina-Marie, Georgeson, Erik, Kubitz, Michael, Burns, Alison, Barman, Shawn, Mopuri, Rohini, Metz, Amanda, Altheide, Tasha K, Diedrich, Jolene K, Saha, Swati, Shields, Kaitlyn, Schultze, Steven E, Smith, Melissa L, Schiffner, Torben, Burton, Dennis R, Watson, Corey T, Bosinger, Steven E, Crispin, Max, Yates, 3rd, John R, Paulson, James C, Ward, Andrew B, Sok, Devin, Crotty, Shane, Schief, William R

“…Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However,…”
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Embracing diversity gives antibodies the power to bind by Sutton, Henry J, Pepper, Marion, Cockburn, Ian A

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Author Correction: Long-primed germinal centres with enduring affinity maturation and clonal migration by Lee, Jeong Hyun, Sutton, Henry J., Cottrell, Christopher A., Phung, Ivy, Ozorowski, Gabriel, Sewall, Leigh M., Nedellec, Rebecca, Nakao, Catherine, Silva, Murillo, Richey, Sara T., Torres, Jonathan L., Lee, Wen-Hsin, Georgeson, Erik, Kubitz, Michael, Hodges, Sam, Mullen, Tina-Marie, Adachi, Yumiko, Cirelli, Kimberly M., Kaur, Amitinder, Allers, Carolina, Fahlberg, Marissa, Grasperge, Brooke F., Dufour, Jason P., Schiro, Faith, Aye, Pyone P., Kalyuzhniy, Oleksandr, Liguori, Alessia, Carnathan, Diane G., Silvestri, Guido, Shen, Xiaoying, Montefiori, David C., Veazey, Ronald S., Ward, Andrew B., Hangartner, Lars, Burton, Dennis R., Irvine, Darrell J., Schief, William R., Crotty, Shane

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Embracing diversity gives antibodies the power to bind: Antibody insertions aid binding by Sutton, Henry J, Pepper, Marion, Cockburn, Ian A

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Vaccine priming of rare HIV broadly neutralizing antibody precursors in non-human primates by Steichen, Jon M, Phung, Ivy, Salcedo, Eugenia, Ozorowski, Gabriel, Willis, Jordan R., Baboo, Sabyasachi, Liguori, Alessia, Cottrell, Christopher A., Torres, Jonathan L., Madden, Patrick J., Ma, Krystal M., Sutton, Henry J., Lee, Jeong Hyun, Kalyuzhniy, Oleksandr, Allen, Joel D., Rodriguez, Oscar L., Adachi, Yumiko, Mullen, Tina-Marie, Georgeson, Erik, Kubitz, Michael, Burns, Alison, Barman, Shawn, Mopuri, Rohini, Metz, Amanda, Altheide, Tasha K., Diedrich, Jolene K., Saha, Swati, Shields, Kaitlyn, Schultze, Steven E., Smith, Melissa L., Schiffner, Torben, Burton, Dennis R., Watson, Corey T., Bosinger, Steven E., Crispin, Max, Yates, John R., Paulson, James C., Ward, Andrew B., Sok, Devin, Crotty, Shane, Schief, William R.

“…Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV) and…”
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