Search Results - "Sutton, Harold G"

Poly(ADP-Ribose) Polymerase Inhibitor Induces Accelerated Senescence in Irradiated Breast Cancer Cells and Tumors by EFIMOVA, Elena V, MAUCERI, Helena J, KRON, Stephen J, WEICHSELBAUM, Ralph R, GOLDEN, Daniel W, LABAY, Edwardine, BINDOKAS, Vytautas P, DARGA, Thomas E, CHAKRABORTY, Chaitali, CAMILO BARRETO-ANDRADE, Juan, CRAWLEY, Clayton, SUTTON, Harold G

“…Persistent DNA double-strand breaks (DSB) may determine the antitumor effects of ionizing radiation (IR) by inducing apoptosis, necrosis, mitotic catastrophe,…”
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STAT1 pathway mediates amplification of metastatic potential and resistance to therapy by Khodarev, Nikolai N, Roach, Paul, Pitroda, Sean P, Golden, Daniel W, Bhayani, Mihir, Shao, Michael Y, Darga, Thomas E, Beveridge, Mara G, Sood, Ravi F, Sutton, Harold G, Beckett, Michael A, Mauceri, Helena J, Posner, Mitchell C, Weichselbaum, Ralph R

“…Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constitutively…”
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Tumor endothelial inflammation predicts clinical outcome in diverse human cancers by Pitroda, Sean P, Zhou, Tong, Sweis, Randy F, Filippo, Matthew, Labay, Edwardine, Beckett, Michael A, Mauceri, Helena J, Liang, Hua, Darga, Thomas E, Perakis, Samantha, Khan, Sajid A, Sutton, Harold G, Zhang, Wei, Khodarev, Nikolai N, Garcia, Joe G N, Weichselbaum, Ralph R

“…Vascular endothelial cells contribute to the pathogenesis of numerous human diseases by actively regulating the stromal inflammatory response; however, little…”
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HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation by Efimova, Elena V, Ricco, Natalia, Labay, Edwardine, Mauceri, Helena J, Flor, Amy C, Ramamurthy, Aishwarya, Sutton, Harold G, Weichselbaum, Ralph R, Kron, Stephen J

“…Despite significant advances in combinations of radiotherapy and chemotherapy, altered fractionation schedules and image-guided radiotherapy, many cancer…”
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A Survivin-Associated Adaptive Response in Radiation Therapy by GRDINA, David J, MURLEY, Jeffrey S, MILLER, Richard C, MAUCERI, Helena J, SUTTON, Harold G, JIAN JIAN LI, WOLOSCHAK, Gayle E, WEICHSELBAUM, Ralph R

“…Adaptive responses can be induced in cells by very low doses of ionizing radiation resulting in an enhanced resistance to much larger exposures. The inhibitor…”
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Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation by Barreto-Andrade, Juan Camilo, Efimova, Elena V, Mauceri, Helena J, Beckett, Michael A, Sutton, Harold G, Darga, Thomas E, Vokes, Everett E, Posner, Mitchell C, Kron, Stephen J, Weichselbaum, Ralph R

“…Radiation therapy remains a promising modality for curative treatment of localized prostate cancer, but dose-limiting toxicities significantly limit its…”
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Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers by Labay, Edwardine, Mauceri, Helena J, Efimova, Elena V, Flor, Amy C, Sutton, Harold G, Kron, Stephen J, Weichselbaum, Ralph R

“…Radiation therapy remains a significant therapeutic modality in the treatment of cancer. An attractive strategy would be to enhance the benefits of ionizing…”
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A Manganese Superoxide Dismutase (SOD2)-Mediated Adaptive Response by Grdina, David J., Murley, Jeffrey S., Miller, Richard C., Mauceri, Helena J., Sutton, Harold G., Thirman, Michael J., Li, Jian Jian, Woloschak, Gayle E., Weichselbaum, Ralph R.

“…Very low doses of ionizing radiation, 5 to 100 mGy, can induce adaptive responses characterized by elevation in cell survival and reduction in micronuclei…”
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Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer by MA UCERI, Helena J, SUTTON, Harold G, DARGA, Thomas E, KOCHERGINSKY, Masha, KOCHANSKI, Joel, WEICHSELBAUM, Ralph R, VOKES, Everett E

“…Signaling pathways that activate mTOR (mammalian target of rapamycin) are altered in many human cancers and these alterations are associated with prognosis and…”
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Abstract 67: A novel survivin-mediated adaptive response induced by very low dose imaging-level exposures and radiation therapy by Murley, Jeffrey S., Miller, Richard C., Mauceri, Helena J., Sutton, Harold G., Weichselbaum, Ralph R., Grdina, David J.

“…Abstract Exposure of cells to a very low dose of ionizing radiation can induce an enhanced resistance or adaptive response to a subsequent larger radiation…”
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Abstract LB-363: DNA-damage foci persistence and accelerated senescence as determinants of radiosensitization by PARP inhibitors by Efimova, Elena V., Mauceri, Helena J., Barreto, Juan C., Labay, Edwardine, Sikora, Jacek, Takahashi, Satoe, Wolfgeher, Don W., Bindokas, Vytautas P., Darga, Thomas E., Beckett, Michael A., Sutton, Harold G., Vokes, Everett E., Posner, Mitchell C., Weichselbaum, Ralph R., Kron, Stephen J.

“…Abstract Along with apoptosis and necrosis, accelerated senescence may be a desirable outcome when replicative cancer cells undergo unrepairable DNA double…”
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Abstract 44: STAT1-dependent expression of genes and proteins involved in energy metabolism links tumor growth and radioresistance to the Warburg effect and predicts poor prognosis in cancer patients by Khodarev, Nikolai N., Pitroda, Sean P., Wakim, Bassam T., Golden, Daniel W., Beckett, Michael A., Mauceri, Helena J., Sutton, Harold G., Perakis, Samantha, Malik, Renuku, Wietholt, Christian, Pelizzari, Charles, Chen, Chin-Tu, Weichselbaum, Ralph R.

“…Abstract Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a…”
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The transfacial approach for combined anterior craniofacial tumor ablation by Panje, W R, Dohrmann, 3rd, G J, Pitcock, J K, Scher, N, Weichselbaum, R R, Sutton, Jr, H G, Vokes, E, Moss, J

“…The transfacial approach to the anterior cranial fossa for tumor removal provides for excellent surgical exposure, improved postoperative appearance, and a…”
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Computer-aided geometric reconstruction of Fletcher-Suit source positions by Li, S, Pelizzari, C A, Reft, C, Sutton, H G, Chen, G T

“…A computer-aided method for reconstruction of the source positions of a Fletcher-Suit applicator has been developed. The tandem source positions are determined…”
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A randomized study comparing two regimens of neoadjuvant and adjuvant chemotherapy in multimodal therapy for locally advanced head and neck cancer by Vokes, E E, Panje, W R, Mick, R, Kozloff, M F, Moran, W J, Sutton, H G, Goldman, M D, Tybor, A G, Weichselbaum, R R

“…Two regimens of neoadjuvant chemotherapy for previously untreated patients with locally advanced head and neck cancer were compared with the goal of…”
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Localized prostate cancer: use of serial prostate-specific antigen measurements during radiation therapy by Vijayakumar, S, Quadri, S F, Karrison, T G, Trinidad, C O, Chan, S K, Halpern, H J, Rubin, S J, Sutton, H G

“…The serum half-life of prostate-specific antigen (PSA) after radical prostatectomy is about 3 days; to the authors' knowledge, the PSA half-life during…”
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Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer by Vokes, E E, Haraf, D J, Weichselbaum, R R, McEvilly, J M, Sutton, H G, Panje, W R

“…Concomitant chemoradiotherapy has resulted in small increases in disease-free or overall survival for patients with advanced head and neck cancer when…”
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Preoperative radiotherapy followed by radical vulvectomy with inguinal lymphadenectomy for advanced vulvar carcinomas by Rotmensch, J, Rubin, S J, Sutton, H G, Javaheri, G, Halpern, H J, Schwartz, J L, Stewart, M, Weichselbaum, R R, Herbst, A L

“…A therapeutic alternative to exenteration for large locally advanced vulvar carcinoma involving the rectum, anus, or vagina is the use of preoperative…”
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Late effects of adjuvant radiotherapy for breast cancer by Ferguson, D J, Sutton, Jr, H G, Dawson, P J

“…Complications requiring in-hospital treatment were observed in 24 of 221 consecutively treated patients (11%) who were followed from 8 to 42 years after…”
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