Search Results - "Sutton, Caroline E."

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases by Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

“…A selective, small-molecule inhibitor of NLRP3 suppresses activation of the inflammasome in vitro and in vivo and attenuates inflammatory disease. The NOD-like…”
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Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine by Ross, Pádraig J, Sutton, Caroline E, Higgins, Sarah, Allen, Aideen C, Walsh, Kevin, Misiak, Alicja, Lavelle, Ed C, McLoughlin, Rachel M, Mills, Kingston H G

“…Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One…”
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Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease by Sutton, Caroline E., Finlay, Conor M., Raverdeau, Mathilde, Early, James O., DeCourcey, Joseph, Zaslona, Zbigniew, O’Neill, Luke A. J., Mills, Kingston H. G., Curtis, Annie M.

“…The transcription factor BMAL1 is a core component of the molecular clock, regulating biological pathways that drive 24 h (circadian) rhythms in behaviour and…”
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Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis by Dunne, Aisling, Ross, Pádraig J, Pospisilova, Eva, Masin, Jiri, Meaney, Aoife, Sutton, Caroline E, Iwakura, Yoichiro, Tschopp, Jurg, Sebo, Peter, Mills, Kingston H G

“…Inflammasome-mediated IL-1beta production is central to the innate immune defects that give rise to certain autoinflammatory diseases and may also be…”
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PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection by Baran, Marcin, Feriotti, Claudia, McGinley, Aoife, Carlile, Simon R., Jiang, Zhaozhao, Calderon-Gonzalez, Ricardo, Dumigan, Amy, Sá-Pessoa, Joana, Sutton, Caroline E., Kearney, Jay, McLoughlin, Rachel M., Mills, Kingston H.G., Fitzgerald, Katherine A., Bengeochea, Jose A., Bowie, Andrew G.

“…PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. We…”
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Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease by Brereton, Corinna F, Sutton, Caroline E, Lalor, Stephen J, Lavelle, Ed C, Mills, Kingston H. G

“…IL-17-producing CD4(+) T (Th17) cells are pathogenic in many autoimmune diseases. The induction and expansion of Th17 cells is directed by cytokines, including…”
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Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity by Angiari, Stefano, Runtsch, Marah C., Sutton, Caroline E., Palsson-McDermott, Eva M., Kelly, Beth, Rana, Nisha, Kane, Harry, Papadopoulou, Gina, Pearce, Erika L., Mills, Kingston H.G., O'Neill, Luke A.J.

“…Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of…”
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Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells by McGinley, Aoife M., Sutton, Caroline E., Edwards, Sarah C., Leane, Charlotte M., DeCourcey, Joseph, Teijeiro, Ana, Hamilton, John A., Boon, Louis, Djouder, Nabil, Mills, Kingston H.G.

“…Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is…”
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IL‐17‐producing γδ T cells and innate lymphoid cells by Sutton, Caroline E., Mielke, Lisa A., Mills, Kingston H. G.

“…The inflammatory cytokine IL‐17 plays a critical role in immunity to infection and is involved in the inflammatory pathology associated with certain autoimmune…”
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Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation by Mielke, Lisa A, Jones, Sarah A, Raverdeau, Mathilde, Higgs, Rowan, Stefanska, Anna, Groom, Joanna R, Misiak, Alicja, Dungan, Lara S, Sutton, Caroline E, Streubel, Gundula, Bracken, Adrian P, Mills, Kingston H G

“…Retinoic acid (RA), a vitamin A metabolite, modulates mucosal T helper cell responses. Here we examined the role of RA in regulating IL-22 production by γδ T…”
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PD‐1 regulation of pathogenic IL‐17‐secreting γδ T cells in experimental autoimmune encephalomyelitis by Leane, Charlotte M., Sutton, Caroline E., Moran, Barry, Mills, Kingston H.G.

“…The PD‐1‐PD‐L1 immune checkpoint helps to maintain self‐tolerance and prevent the development of autoimmune diseases. Immune checkpoint inhibitors are…”
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A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans by Edwards, Sarah C, Sutton, Caroline E, Ladell, Kristin, Grant, Emma J, McLaren, James E, Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L, Lalor, Stephen J, Ribot, Julie C, Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A, Thomas, Paul G, McLoughlin, Rachel M, Mills, Kingston H G

“…T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in…”
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Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation by Hughes, Mark M., Hooftman, Alexander, Angiari, Stefano, Tummala, Padmaja, Zaslona, Zbigniew, Runtsch, Marah C., McGettrick, Anne F., Sutton, Caroline E., Diskin, Ciana, Rooke, Melissa, Takahashi, Shuhei, Sundararaj, Srinivasan, Casarotto, Marco G., Dahlstrom, Jane E., Palsson-McDermott, Eva M., Corr, Sinead C., Mills, Kingston H.G., Preston, Roger J.S., Neamati, Nouri, Xie, Yiyue, Baell, Jonathan B., Board, Philip G., O’Neill, Luke A.J.

“…The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the…”
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Therapeutic potential of targeting IL-17 by Jones, Sarah A, Sutton, Caroline E, Cua, Daniel, Mills, Kingston H G

“…A June 2012 meeting in Dublin, Ireland, showcased advances in the understanding of the role of IL-17 and related cytokines in host immunity and how these…”
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Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production by Brereton, Corinna F, Sutton, Caroline E, Ross, Pádraig J, Iwakura, Yoichiro, Pizza, Mariagrazia, Rappuoli, Rino, Lavelle, Ed C, Mills, Kingston H G

“…Escherichia coli heat-labile enterotoxin (LT) is a powerful mucosal adjuvant; however, it is associated with toxic effects when delivered intranasally, and its…”
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Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production by Masters, Seth L, Mielke, Lisa A, Cornish, Ann L, Sutton, Caroline E, O'Donnell, Joanne, Cengia, Louise H, Roberts, Andrew W, Wicks, Ian P, Mills, Kingston H G, Croker, Ben A

“…Reports describing the effect of interferon‐γ (IFNγ) on interleukin‐1β (IL‐1β) production are conflicting. We resolve this controversy by showing that IFNγ…”
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Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction by Pindjakova, Jana, Hanley, Shirley A, Duffy, Michelle M, Sutton, Caroline E, Weidhofer, Gudrun A, Miller, Melinda N, Nath, Karl A, Mills, Kingston H G, Ceredig, Rhodri, Griffin, Matthew D

“…Interleukin 17A-secreting T-helper 17 (Th17) cells are pathogenic in inflammatory kidney diseases, but their intrarenal regulation is poorly understood. In…”
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Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity by Sutton, Caroline E., Lalor, Stephen J., Sweeney, Cheryl M., Brereton, Corinna F., Lavelle, Ed C., Mills, Kingston H.G.

“…Th17 cells, CD4+ T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the…”
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Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity by Lalor, Stephen J., Dungan, Lara S., Sutton, Caroline E., Basdeo, Sharee A., Fletcher, Jean M., Mills, Kingston H. G.

“…Abstract IL-1β plays a critical role in promoting IL-17 production by γδ and CD4 T cells. However, IL-1–targeted drugs, although effective against…”
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41 by Edwards, Sarah C., Sutton, Caroline E., Mills, Kingston H.G.

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