Search Results - "Sutton, Brian J"

Multi-faceted immunoglobulin M meets its elusive receptor by Sutton, Brian J.

“…Immunoglobulin M (IgM) is the most ancient antibody class and key mediator of the primary immune response. New structures reveal how it binds to its only…”
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Human IgG4: a structural perspective by Davies, Anna M., Sutton, Brian J.

“…Summary IgG4, the least represented human IgG subclass in serum, is an intriguing antibody with unique biological properties, such as the ability to undergo…”
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Aggressive angiomyxoma by Sutton, Brian J, Laudadio, Jennifer

“…Aggressive angiomyxoma is a rare mesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive…”
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Structural Determinants of Unique Properties of Human IgG4-Fc by Davies, Anna M., Rispens, Theo, Ooijevaar-de Heer, Pleuni, Gould, Hannah J., Jefferis, Roy, Aalberse, Rob C., Sutton, Brian J.

“…Human IgG4, normally the least abundant of the four subclasses of IgG in serum, displays a number of unique biological properties. It can undergo heavy-chain…”
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IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2‐specific IgE by Santos, Alexandra F., BARBOSA MORAIS, NUNO LUÍS, Hurlburt, Barry K., Ramaswamy, Sneha, Hemmings, Oliver, Kwok, Matthew, O’Rourke, Colin, Bahnson, Henry T., Cheng, Hsiaopo, James, Louisa, Gould, Hannah J., Sutton, Brian J., Maleki, Soheila J., Lack, Gideon

“…© 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under…”
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The evolution of flexibility and function in the Fc domains of IgM, IgY, and IgE by Calvert, Rosaleen A, Nyamboya, Rosemary A, Beavil, Andrew J, Sutton, Brian J

“…Antibody Fc regions harbour the binding sites for receptors that mediate effector functions following antigen engagement by the Fab regions. An extended…”
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Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab by Davies, Anna M., Allan, Elizabeth G., Keeble, Anthony H., Delgado, Jean, Cossins, Benjamin P., Mitropoulou, Alkistis N., Pang, Marie O.Y., Ceska, Tom, Beavil, Andrew J., Craggs, Graham, Westwood, Marta, Henry, Alistair J., McDonnell, James M., Sutton, Brian J.

“…Immunoglobulin E and its interactions with receptors FcɛRI and CD23 play a central role in allergic disease. Omalizumab, a clinically approved therapeutic…”
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Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange by Rispens, Theo, Davies, Anna M., Ooijevaar-de Heer, Pleuni, Absalah, Samira, Bende, Onno, Sutton, Brian J., Vidarsson, Gestur, Aalberse, Rob C.

“…Interdomain interactions between the CH3 domains of antibody heavy chains are the first step in antibody assembly and are of prime importance for maintaining…”
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IgG4 Characteristics and Functions in Cancer Immunity by Crescioli, Silvia, Correa, Isabel, Karagiannis, Panagiotis, Davies, Anna M., Sutton, Brian J., Nestle, Frank O., Karagiannis, Sophia N.

“…IgG4 is the least abundant subclass of IgG in normal human serum, but elevated IgG4 levels are triggered in response to a chronic antigenic stimulus and…”
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Differences between Human and Mouse IgM Fc Receptor (FcµR) by Kubagawa, Hiromi, Skopnik, Christopher M., Al-Qaisi, Khlowd, Calvert, Rosaleen A., Honjo, Kazuhito, Kubagawa, Yoshiki, Teuber, Ruth, Aliabadi, Pedram Mahmoudi, Enghard, Philipp, Radbruch, Andreas, Sutton, Brian J.

“…Both non-immune “natural” and antigen-induced “immune” IgM are important for protection against pathogens and for regulation of immune responses to…”
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IgE Antibodies: From Structure to Function and Clinical Translation by Sutton, Brian J, Davies, Anna M, Bax, Heather J, Karagiannis, Sophia N

“…Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic reactions, and their powerful effector functions activated through…”
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Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps by Chen, Jiun-Bo, PhD, James, Louisa K., PhD, Davies, Anna M., PhD, Wu, Yu-Chang Bryan, PhD, Rimmer, Joanne, FRCS, Lund, Valerie J., MS, FRCS, Chen, Jou-Han, MS, McDonnell, James M., PhD, Chan, Yih-Chih, PhD, Hutchins, George H., BSci, Chang, Tse Wen, PhD, Sutton, Brian J., DPhil, Kariyawasam, Harsha H., FRCP, PhD, Gould, Hannah J., PhD

“…Background Chronic rhinosinusitis with nasal polyps is associated with local immunoglobulin hyperproduction and the presence of IgE antibodies against…”
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Identification of Amino Acid Residues in Human IgM Fc Receptor (FcµR) Critical for IgM Binding by Skopnik, Christopher M, Al-Qaisi, Khlowd, Calvert, Rosaleen A, Enghard, Philipp, Radbruch, Andreas, Sutton, Brian J, Kubagawa, Hiromi

“…Both non-immune "natural" and antigen-induced "immune" IgM are important for protection against infections and for regulation of immune responses to…”
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Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcεRI by Dhaliwal, Balvinder, Yuan, Daopeng, Pang, Marie O. Y, Henry, Alistair J, Cain, Katharine, Oxbrow, Amanda, Fabiane, Stella M, Beavil, Andrew J, McDonnell, James M, Gould, Hannah J, Sutton, Brian J

“…The role of IgE in allergic disease mechanisms is performed principally through its interactions with two receptors, FcεRI on mast cells and basophils, and…”
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Mechanism of the Antigen-Independent Cytokinergic SPE-7 IgE Activation of Human Mast Cells in Vitro by Bax, Heather J., Bowen, Holly, Dodev, Tihomir S., Sutton, Brian J., Gould, Hannah J.

“…Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The ‘dogma’ is that IgE molecules merely sensitise mast cells by…”
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Crystal structures of murine and human Histamine-Releasing Factor (HRF/TCTP) and a model for HRF dimerisation in mast cell activation by Doré, Katy A., Kashiwakura, Jun-ichi, McDonnell, James M., Gould, Hannah J., Kawakami, Toshiaki, Sutton, Brian J., Davies, Anna M.

“…•First crystal structure of murine HRF solved.•Crystal structure of human HRF solved at the highest resolution yet reported.•Human HRF structure contains a…”
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Antibody mimetics: promising complementary agents to animal-sourced antibodies by Baloch, Abdul Rasheed, Baloch, Abdul Wahid, Sutton, Brian J, Zhang, Xiaoying

“…Despite their wide use as therapeutic, diagnostic and detection agents, the limitations of polyclonal and monoclonal antibodies have inspired scientists to…”
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Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility by Tomatis, Pablo E, Fabiane, Stella M, Simona, Fabio, Carloni, Paolo, Sutton, Brian J, Vila, Alejandro J

“…Protein evolution is crucial for organismal adaptation and fitness. This process takes place by shaping a given 3-dimensional fold for its particular…”
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THE BIOLOGY OF IGE AND THE BASIS OF ALLERGIC DISEASE by Gould, Hannah J, Sutton, Brian J, Beavil, Andrew J, Beavil, Rebecca L, McCloskey, Natalie, Coker, Heather A, Fear, David, Smurthwaite, Lyn

“…Allergic individuals exposed to minute quantities of allergen experience an immediate response. Immediate hypersensitivity reflects the permanent sensitization…”
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Soluble CD23 controls IgE synthesis and homeostasis in human B cells by Cooper, Alison M, Hobson, Philip S, Jutton, Mark R, Kao, Michael W, Drung, Binia, Schmidt, Boris, Fear, David J, Beavil, Andrew J, McDonnell, James M, Sutton, Brian J, Gould, Hannah J

“…CD23, the low-affinity receptor for IgE, exists in membrane and soluble forms. Soluble CD23 (sCD23) fragments are released from membrane (m)CD23 by the…”
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