Search Results - "Suttle, B."

Species Interactions Reverse Grassland Responses to Changing Climate by Suttle, K.B, Thomsen, Meredith A, Power, Mary E

“…Predictions of ecological response to climate change are based largely on direct climatic effects on species. We show that, in a California grassland, species…”
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Relationships between pazopanib exposure and clinical safety and efficacy in patients with advanced renal cell carcinoma by Suttle, A B, Ball, H A, Molimard, M, Hutson, T E, Carpenter, C, Rajagopalan, D, Lin, Y, Swann, S, Amado, R, Pandite, L

“…Background: Pazopanib, an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor…”
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Conservation when nothing stands still: moving targets and biodiversity offsets by Bull, Joseph W, Suttle, Kenwyn B, Singh, Navinder J, Milner-Gulland, EJ

“…Conservation is particularly difficult to implement for "moving targets", such as migratory species or landscapes subject to environmental change. Traditional…”
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Importance of Baseline Specification in Evaluating Conservation Interventions and Achieving No Net Loss of Biodiversity by BULL, J. W, GORDON, A, LAW, E. A, SUTTLE, K. B, MILNER‐GULLAND, E. J

“…There is an urgent need to improve the evaluation of conservation interventions. This requires specifying an objective and a frame of reference from which to…”
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Comparing biodiversity offset calculation methods with a case study in Uzbekistan by Bull, J.W., Milner-Gulland, E.J., Suttle, K.B., Singh, N.J.

“…•We apply various existing biodiversity offset methodologies to a common case study.•We use data from 40years of natural gas extraction and impact in NW…”
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Proteogenomic analyses indicate bacterial methylotrophy and archaeal heterotrophy are prevalent below the grass root zone by Butterfield, Cristina N, Li, Zhou, Andeer, Peter F, Spaulding, Susan, Thomas, Brian C, Singh, Andrea, Hettich, Robert L, Suttle, Kenwyn B, Probst, Alexander J, Tringe, Susannah G, Northen, Trent, Pan, Chongle, Banfield, Jillian F

“…Annually, half of all plant-derived carbon is added to soil where it is microbially respired to CO . However, understanding of the microbiology of this process…”
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Pollinators as mediators of top-down effects on plants by Suttle, Kenwyn B.

“…This paper explores the idea that predators may disrupt plant–pollinator relationships and consequently inhibit reproduction in flowering plants. Amidst…”
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How Fine Sediment in Riverbeds Impairs Growth and Survival of Juvenile Salmonids by Kenwyn B. Suttle, Power, Mary E., Levine, Jonathan M., Camille Mc Neely

“…Although excessive loading of fine sediments into rivers is well known to degrade salmonid spawning habitat, its effects on rearing juveniles have been…”
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A Phase I Study of the Pharmacokinetic and Safety Profiles of Oral Pazopanib With a High-Fat or Low-Fat Meal in Patients With Advanced Solid Tumors by Heath, E I, Chiorean, E G, Sweeney, C J, Hodge, J P, Lager, J J, Forman, K, Malburg, L, Arumugham, T, Dar, M M, Suttle, A B, Gainer, S D, LoRusso, P

“…Pazopanib is an oral angiogenesis inhibitor of vascular endothelial growth factor (VEGF) receptor, platelet‐derived growth factor receptor, and cytokine…”
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Phase I study of weekly paclitaxel in combination with pazopanib and lapatinib in advanced solid malignancies by Tan, A R, Dowlati, A, Stein, M N, Jones, S F, Infante, J R, Bendell, J, Kane, M P, Levinson, K T, Suttle, A B, Burris III, H A

“…Background: We assessed the maximum tolerated regimen (MTR) and dose-limiting toxicities of pazopanib and lapatinib in combination with weekly paclitaxel, and…”
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Pazopanib exposure decreases as a result of an ifosfamide-dependent drug–drug interaction: results of a phase I study by Hamberg, P, Boers-Sonderen, M J, van der Graaf, W T A, de Bruijn, P, Suttle, A B, Eskens, F A L M, Verweij, J, van Herpen, C M L, Sleijfer, S

“…Background: The vascular endothelial growth factor receptor (VEGFR) pathway plays a pivotal role in solid malignancies and is probably involved in chemotherapy…”
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Ecological resistance, seed density and their interactions determine patterns of invasion in a California coastal grassland by Thomsen, Meredith A, D'Antonio, Carla M, Suttle, Kenwyn B, Sousa, Wayne P

“…Relatively little experimental evidence is available regarding how ecological resistance and propagule density interact in their effects on the establishment…”
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Preclinical Modeling of Tumor Growth and Angiogenesis Inhibition to Describe Pazopanib Clinical Effects in Renal Cell Carcinoma by Ouerdani, A, Struemper, H, Suttle, AB, Ouellet, D, Ribba, B

“…The objective was to leverage tumor size data from preclinical experiments to propose a model of tumor growth and angiogenesis inhibition for the analysis of…”
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Ambient changes exceed treatment effects on plant species abundance in global change experiments by Langley, J. Adam, Chapman, Samantha K., La Pierre, Kimberly J., Avolio, Meghan, Bowman, William D., Johnson, David S., Isbell, Forest, Wilcox, Kevin R., Foster, Bryan L., Hovenden, Mark J., Knapp, Alan K., Koerner, Sally E., Lortie, Christopher J., Megonigal, James P., Newton, Paul C. D., Reich, Peter B., Smith, Melinda D., Suttle, Kenwyn B., Tilman, David

“…The responses of species to environmental changes will determine future community composition and ecosystem function. Many syntheses of global change…”
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Grassland responses to increased rainfall depend on the timescale of forcing by Sullivan, Martin J. P., A.Thomsen, Meredith, Suttle, K. B.

“…Forecasting impacts of future climate change is an important challenge to biologists, both for understanding the consequences of different emissions…”
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An Evaluation of the Drug Interaction Potential of Pazopanib, an Oral Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, Using a Modified Cooperstown 5+1 Cocktail in Patients With Advanced Solid Tumors by Goh, B C, Reddy, N J, Dandamudi, U B, Laubscher, K H, Peckham, T, Hodge, J P, Suttle, A B, Arumugham, T, Xu, Y, Xu, C‐F, Lager, J, Dar, M M, Lewis, L D

“…Pazopanib, an oral inhibitor of vascular endothelial growth factor receptor, platelet‐derived growth factor receptor, and c‐kit kinases, inhibits multiple…”
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Effects of Top Predator Species on Direct and Indirect Interactions in a Food Web by Schmitz, Oswald J., Suttle, K. Blake

“…Current theory on trophic interactions in food webs assumes that ecologically similar species can be treated collectively as a single functional unit such as a…”
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Quantifying habitat impacts of natural gas infrastructure to facilitate biodiversity offsetting by Jones, Isabel L., Bull, Joseph W., Milner‐Gulland, Eleanor J., Esipov, Alexander V., Suttle, Kenwyn B.

“…Habitat degradation through anthropogenic development is a key driver of biodiversity loss. One way to compensate losses is “biodiversity offsetting” (wherein…”
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72 (PB060): TYRA-300, an oral, FGFR3-selective inhibitor: Preliminary pharmacokinetic and pharmacodynamic analysis from SURF301, the multicenter open-label phase 1/2 study of TYRA-300 in advanced urothelial carcinoma and other solid tumors with activating FGFR3 alterations by Loriot, Y., Zhang, A., Hansen, A., Mantia, C., Boni, V., Weickhardt, A., Yu, E.Y., Robert, M., Iyer, G., Murtha, A., Owens, S., Suttle, B., Vandekerkhove, G., Wyatt, A., Gammon, G., Burn, T., Tran, B.

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Production of succinic acid by Anaerobiospirillum succiniciproducens by Nghiem, N.P, Davison, B.H, Suttle, B.E, Richardson, G.R

“…The effect of an external supply of carbon dioxide and pH on the production of succinic acid by Anaerobiospirillum succiniciproducens was studied. In a rich…”
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