Search Results - "Suto, Mark J."

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion by Sharma, Jyoti, Du, Ming, Wong, Eric, Mutyam, Venkateshwar, Li, Yao, Chen, Jianguo, Wangen, Jamie, Thrasher, Kari, Fu, Lianwu, Peng, Ning, Tang, Liping, Liu, Kaimao, Mathew, Bini, Bostwick, Robert J., Augelli-Szafran, Corinne E., Bihler, Hermann, Liang, Feng, Mahiou, Jerome, Saltz, Josef, Rab, Andras, Hong, Jeong, Sorscher, Eric J., Mendenhall, Eric M., Coppola, Candice J., Keeling, Kim M., Green, Rachel, Mense, Martin, Suto, Mark J., Rowe, Steven M., Bedwell, David M.

“…Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also…”
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Discovery of a novel inhibitor of kinesin-like protein KIFC1 by Zhang, Wei, Zhai, Ling, Wang, Yimin, Boohaker, Rebecca J, Lu, Wenyan, Gupta, Vandana V, Padmalayam, Indira, Bostwick, Robert J, White, E Lucile, Ross, Larry J, Maddry, Joseph, Ananthan, Subramaniam, Augelli-Szafran, Corinne E, Suto, Mark J, Xu, Bo, Li, Rongbao, Li, Yonghe

“…Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of…”
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Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease by Murphy-Ullrich, Joanne E., Suto, Mark J.

“…Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with global inhibitors of TGF-β have been disappointing,…”
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GLI1 Inhibitor SRI-38832 Attenuates Chemotherapeutic Resistance by Downregulating NBS1 Transcription in BRAFV600E Colorectal Cancer by Zhang, Ruowen, Ma, Jinlu, Avery, Justin T., Sambandam, Vijaya, Nguyen, Theresa H., Xu, Bo, Suto, Mark J., Boohaker, Rebecca J.

“…Resistance to radiation and chemotherapy in colorectal cancer (CRC) patients contribute significantly to refractory disease and disease progression. Herein, we…”
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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Ptak, Roger G., Cai, Zhaohui, Huang, Chunsheng, Peng, Junzhong, Kalkeri, Raj, Suto, Mark J.

“…Approximately 257 million people chronically infected with hepatitis B virus (HBV) worldwide are at risk of developing hepatocellular carcinoma (HCC). However,…”
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The wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer by King, Taj D., Suto, Mark J., Li, Yonghe

“…Breast cancer continues to be a serious health problem particularly in developed countries. Of particular concern is triple negative breast cancer (TNBC) which…”
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Identification of Cytoprotective Small-Molecule Inducers of Heme-Oxygenase-1 by Ghajar-Rahimi, Gelare, Traylor, Amie M, Mathew, Bini, Bostwick, James R, Nebane, N Miranda, Zmijewska, Anna A, Esman, Stephanie K, Thukral, Saakshi, Zhai, Ling, Sambandam, Vijaya, Cowell, Rita M, Suto, Mark J, George, James F, Augelli-Szafran, Corinne E, Agarwal, Anupam

“…Acute kidney injury (AKI) is a major public health concern with significant morbidity and mortality and no current treatments beyond supportive care and…”
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Janet A. Houghton, PhD: In Memoriam (1952–2017) by Suto, Mark J.

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Frizzled7 as an emerging target for cancer therapy by King, Taj D., Zhang, Wei, Suto, Mark J., Li, Yonghe

“…Wnt proteins are secreted glycoproteins that bind to the N-terminal extra-cellular cysteine-rich domain of the Frizzled (Fzd) receptor family. The Fzd…”
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Identification of an Anti-diabetic, Orally Available Small Molecule that Regulates TXNIP Expression and Glucagon Action by Thielen, Lance A., Chen, Junqin, Jing, Gu, Moukha-Chafiq, Omar, Xu, Guanlan, Jo, SeongHo, Grayson, Truman B., Lu, Brian, Li, Peng, Augelli-Szafran, Corinne E., Suto, Mark J., Kanke, Matt, Sethupathy, Praveen, Kim, Jason K., Shalev, Anath

“…Diabetes is characterized by hyperglycemia, loss of functional islet beta cell mass, deficiency of glucose-lowering insulin, and persistent alpha cell…”
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Development of novel small molecules for the treatment of ALS by Mathew, Bini, Ruiz, Pedro, Pathak, Vibha, Suto, Mark J.

“…[Display omitted] Amyotrophic lateral sclerosis (ALS) is a rare and progressive neurodegenerative disease with unknown etiology. It is caused by the…”
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Inhibition of Transforming Growth Factor-β Activation Diminishes Tumor Progression and Osteolytic Bone Disease in Mouse Models of Multiple Myeloma by Lu, Ailing, Pallero, Manuel A, Lei, Weiqi, Hong, Huixian, Yang, Yang, Suto, Mark J, Murphy-Ullrich, Joanne E

“…Transforming growth factor (TGF)-β supports multiple myeloma progression and associated osteolytic bone disease. Conversion of latent TGF-β to its biologically…”
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Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain by Zhang, Wei, Lu, Wenyan, Ananthan, Subramaniam, Suto, Mark J, Li, Yonghe

“…Frizzled (Fzd) proteins are seven transmembrane receptors that belong to a novel and separated family of G-protein-coupled receptors (GPCRs). The Fzd receptors…”
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Process Development and Optimization for Production of a Potassium Ion Channel Blocker, ICA-17043 by Mobele, Bingidimi I, Venkatraman, Sripathy, McNaughton-Smith, Grant, Gibb, Cameron, Ulysse, Luckner G, Lindmark, Carl A, Shaw, Stephen, Marron, Brian, Spear, Kerry, Suto, Mark J

“…A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized…”
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Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit by Oliva, Claudia R, Zhang, Wei, Langford, Cathy, Suto, Mark J, Griguer, Corinne E

“…Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes…”
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Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Increasing TSP-1-Dependent TGFβ1 Activation and Suppressing Immunity in Bone Marrow by Zhang, Chao, Xu, Xiaoxuan, Trotter, Timothy N, Gowda, Pramod S, Lu, Yun, Suto, Mark J, Javed, Amjad, Murphy-Ullrich, Joanne E, Li, Juan, Yang, Yang

“…Multiple myeloma is a plasma cell malignancy that thrives in the bone marrow (BM). The proteasome inhibitor bortezomib is one of the most effective first-line…”
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Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations by Mutyam, Venkateshwar, Du, Ming, Xue, Xiaojiao, Keeling, Kim M, White, E Lucile, Bostwick, J Robert, Rasmussen, Lynn, Liu, Bo, Mazur, Marina, Hong, Jeong S, Falk Libby, Emily, Liang, Feng, Shang, Haibo, Mense, Martin, Suto, Mark J, Bedwell, David M, Rowe, Steven M

“…Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). Several agents are known…”
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Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals by Yatchang, Marina Fosso, Mathew, Bini, Srivastava, Ritesh K., Khan, Jasim, Muzaffar, Suhail, Zhang, Sixue, Wu, Mousheng, Zhai, Ling, Ruiz, Pedro, Agarwal, Anupam, Bostwick, James R., Suto, Mark J., Athar, Mohammad, Augelli-Szafran, Corinne E.

“…[Display omitted] Arsenicals belong to the class of chemical warfare agents known as vesicants, which are highly reactive, toxic and cause robust inflammatory…”
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Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β by Suto, Mark J, Gupta, Vandana, Mathew, Bini, Zhang, Wei, Pallero, Manuel A, Murphy-Ullrich, Joanne E

“…TGF-β has been a target of interest for the treatment of fibrotic diseases and certain cancers. Approaches to target TGF-β include antagonists of the active…”
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Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells by Oliva, Claudia R., Markert, Tahireh, Ross, Larry J., White, E. Lucile, Rasmussen, Lynn, Zhang, Wei, Everts, Maaike, Moellering, Douglas R., Bailey, Shannon M., Suto, Mark J., Griguer, Corinne E.

“…The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory…”
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