Search Results - "Sutlu, T."

Natural killer cell‐based immunotherapy in cancer: current insights and future prospects by Sutlu, T., Alici, E.

“… As our understanding of the molecular mechanisms governing natural killer (NK) cell activity increases, their potential in cancer immunotherapy is growing…”
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Clinical impact of chromosomal aberrations in multiple myeloma by Nahi, H., Sutlu, T., Jansson, M., Alici, E., Gahrton, G.

“…  Nahi H., Sutlu T., Jansson M., Alici E., Gahrton G. (Karolinska Institutet, Karolinska University Hospital Huddinge; Hematology Centre, Karolinska…”
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Delivery of short interfering RNA using endosomolytic cell-penetrating peptides by Lundberg, Pontus, El-Andaloussi, S, Sütlü, T, Johansson, H, Langel, Ü

“…Cell-penetrating peptides (CPPs) are peptides able to promote uptake of various cargos, including proteins and plasmids. Advances in recent years imply the…”
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Safety analysis of ex vivo-expanded NK and NK-like T cells administered to cancer patients: a phase I clinical study by Barkholt, Lisbeth, Alici, Evren, Conrad, Reka, Sutlu, Tolga, Gilljam, Mari, Stellan, Birgitta, Christensson, Birger, Guven, Hayrettin, Björkström, Niklas K, Söderdahl, Gunnar, Cederlund, Kerstin, Kimby, Eva, Aschan, Johan, Ringdén, Olle, Ljunggren, Hans-Gustaf, Dilber, M Sirac

“…The chimeric state after allogeneic hematopoietic stem cell transplantation provides a platform for adoptive immunotherapy using donor-derived immune cells…”
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The prognostic significance of 8p21 deletion in multiple myeloma by Sutlu, T., Alici, E., Jansson, M., Wallblom, A., Dilber, M. S., Gahrton, G., Nahi, H.

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Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy by Sutlu, Tolga, Nyström, Sanna, Gilljam, Mari, Stellan, Birgitta, Applequist, Steven E, Alici, Evren

“…Adoptive immunotherapy with genetically modified natural killer (NK) cells is a promising approach for cancer treatment. Yet, optimization of highly efficient…”
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Engineering antigen‐specific NK cell lines against the melanoma‐associated antigen tyrosinase via TCR gene transfer by Parlar, Ayhan, Sayitoglu, Ece Canan, Ozkazanc, Didem, Georgoudaki, Anna‐Maria, Pamukcu, Cevriye, Aras, Mertkaya, Josey, Benjamin J., Chrobok, Michael, Branecki, Suzanne, Zahedimaram, Pegah, Ikromzoda, Lolai, Alici, Evren, Erman, Batu, Duru, Adil D., Sutlu, Tolga

“…Introduction of Chimeric Antigen Receptors to NK cells has so far been the main practical method for targeting NK cells to specific surface antigens. In…”
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Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D by Sayitoglu, Ece Canan, Georgoudaki, Anna-Maria, Chrobok, Michael, Ozkazanc, Didem, Josey, Benjamin J, Arif, Muhammad, Kusser, Kim, Hartman, Michelle, Chinn, Tamara M, Potens, Renee, Pamukcu, Cevriye, Krueger, Robin, Zhang, Cheng, Mardinoglu, Adil, Alici, Evren, Temple, Harry Thomas, Sutlu, Tolga, Duru, Adil Doganay

“…Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many are chemo- and radiotherapy resistant, thus conventional treatments…”
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CD38 Down-Regulation on Ex Vivo Activated and Expanded NK Cells for Cell Therapy Persists after Infusion by Nahi, Hareth, Chrobook, Michael, Meinke, Stephan, Gran, Charlotte, Marquardt, Nicole, Afram, Gabriel, Sutlu, Tolga, Gilljam, Mari, Stellan, Birgitta, Wagner, Arnika Kathleen, Walther-Jallow, Lilian, Liwing, Johan, Klimkowska, Monika, Gahrton, Goesta, Ljungman, Per, Ljunggren, Hans-Gustaf, Alici, Evren

“…Introduction: Immunotherapies are gaining more and more importance in the treatment of multiple myeloma (MM). Antibodies directed against MM antigens like…”
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Identification and strategic targeting of key anti-viral defense mechanisms in Natural Killer cells by Sayitoglu, Ece Canan, Ozkazanc, Didem, Sarac, Aydan, Parlar, Ayhan, Alici, Evren, Erman, Batu, Duru, Adil Doganay, Sutlu, Tolga

“…Abstract While genetic modification of lymphocytes proves to be an efficient approach in immunotherapy, commonly used lentiviral vectors are haunted by the…”
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Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components by Alici, Evren, Sutlu, Tolga, Björkstrand, Bo, Gilljam, Mari, Stellan, Birgitta, Nahi, Hareth, Quezada, Hernan Concha, Gahrton, Gösta, Ljunggren, Hans-Gustaf, Dilber, M. Sirac

“…Multiple myeloma (MM) is an incurable plasma cell malignancy with poor outcome. The most promising therapeutic options currently available are combinations of…”
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Clinical-grade, large-scale, feeder-free expansion of highly active human natural killer cells for adoptive immunotherapy using an automated bioreactor by Sutlu, Tolga, Stellan, Birgitta, Gilljam, Mari, Quezada, Hernan Concha, Nahi, Hareth, Gahrton, Gösta, Alici, Evren

“…Abstract Background aims Natural killer (NK) cell-based adoptive immunotherapy is a promising approach for the treatment of cancer. Ex vivo expansion and…”
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Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma by Nahi, Hareth, Chrobok, Michael, Meinke, Stephan, Gran, Charlotte, Marquardt, Nicole, Afram, Gabriel, Sutlu, Tolga, Gilljam, Mari, Stellan, Birgitta, Wagner, Arnika K., Blomberg, Pontus, Holmqvist, Per-Henrik, Walther-Jallow, Lilian, Mellström, Karin, Liwing, Johan, Gustafsson, Charlotte, Månsson, Robert, Klimkowska, Monika, Gahrton, Gösta, Lund, Johan, Ljungman, Per, Ljunggren, Hans-Gustaf, Alici, Evren

“…Few approaches have been made toward exploring autologous NK cells in settings of cancer immunotherapy. Here, we demonstrate the feasibility of infusing…”
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Functional Assessment for Clinical Use of Serum-Free Adapted NK-92 Cells by Chrobok, Michael, Dahlberg, Carin I M, Sayitoglu, Ece Canan, Beljanski, Vladimir, Nahi, Hareth, Gilljam, Mari, Stellan, Birgitta, Sutlu, Tolga, Duru, Adil Doganay, Alici, Evren

“…Natural killer (NK) cells stand out as promising candidates for cellular immunotherapy due to their capacity to kill malignant cells. However, the therapeutic…”
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Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model by Bestas, Burcu, Moreno, Pedro M D, Blomberg, K Emelie M, Mohammad, Dara K, Saleh, Amer F, Sutlu, Tolga, Nordin, Joel Z, Guterstam, Peter, Gustafsson, Manuela O, Kharazi, Shabnam, Piątosa, Barbara, Roberts, Thomas C, Behlke, Mark A, Wood, Matthew J A, Gait, Michael J, Lundin, Karin E, El Andaloussi, Samir, Månsson, Robert, Berglöf, Anna, Wengel, Jesper, Smith, C I Edvard

“…X-linked agammaglobulinemia (XLA) is an inherited immunodeficiency that results from mutations within the gene encoding Bruton's tyrosine kinase (BTK). Many…”
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Deletion of Chromosomal Region 8p21 Confers Resistance to Bortezomib and Is Associated with Upregulated Decoy TRAIL Receptor Expression in Patients with Multiple Myeloma by Duru, Adil Doganay, Sutlu, Tolga, Wallblom, Ann, Uttervall, Katarina, Lund, Johan, Stellan, Birgitta, Gahrton, Gösta, Nahi, Hareth, Alici, Evren

“…Loss of the chromosomal region 8p21 negatively effects survival in patients with multiple myeloma (MM) that undergo autologous stem cell transplantation…”
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Ex vivo expansion of natural killer cells: a question of function by Sutlu, Tolga, Alici, Evren

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Clinical impact of chromosomal aberrations in multiple myeloma: Review: Impact of chromosomal aberrations in MM by Nahi, H., Sutlu, T., Jansson, M., Alici, E., Gahrton, G.

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86P Effect of chemotherapy-induced autophagic secretome on natural killer cell activity by Karlitepe, A., Celik, E., Sütlü, T., Süzek, T., Kilic Eren, M.K.

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In search of the molecular consequences of 8p21 deletion in multiple myeloma: commentary on Gmidéne et al by Sutlu, Tolga, Alici, Evren, Gahrton, Gösta, Nahi, Hareth

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