Biogenesis of micronuclei

Biogenesis of micronuclei

The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well...

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Bibliographic Details
Published in:Biochemistry (Moscow) Vol. 81; no. 5; pp. 453 - 464
Main Authors: Kisurina-Evgenieva, O. P., Sutiagina, O. I., Onishchenko, G. E.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-05-2016
Springer
Springer Nature B.V
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Biosynthesis
Cell Nucleus - chemistry
Cell Nucleus - genetics
Cell Nucleus - metabolism
Deoxyribonucleic acid
DNA
DNA Damage - drug effects
DNA Damage - radiation effects
DNA Repair
Gamma Rays
Genetics
Heterochromatin - chemistry
Heterochromatin - metabolism
Humans
Interphase
Life Sciences
Microbiology
Mutagens - toxicity
Nuclear Envelope - metabolism
Reactive Oxygen Species - metabolism
Reviews
replication
repair
micronucleus
transcription
elimination
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Description
Summary:The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by the chromosomal material localized inside these cell structures.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297916050035