Search Results - "Sutherland, E Rand"

Overweight, Obesity, and Incident Asthma: A Meta-analysis of Prospective Epidemiologic Studies by Beuther, David A, Sutherland, E. Rand

“…Although obesity has been implicated as an asthma risk factor, there is heterogeneity in the published literature regarding its role in asthma incidence,…”
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A Large Subgroup of Mild-to-Moderate Asthma Is Persistently Noneosinophilic by WONG, Kelly, ICITOVIC, Nikolina, BOUSHEY, Homer A, LAZARUS, Stephen C, RAND SUTHERLAND, E, CHINCHILLI, Vernon M, FAHY, John V

“…Airway eosinophilia is typical of asthma, and many controller treatments target eosinophilic disease. Asthma is clinically heterogeneous, however, and a…”
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The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma by GOLEVA, Elena, JACKSON, Leisa P, KIRK HARRIS, J, ROBERTSON, Charles E, RAND SUTHERLAND, E, HALL, Clifton F, GOOD, James T, GELFAND, Erwin W, MARTIN, Richard J, LEUNG, Donald Y. M

“…The role of airway microbiome in corticosteroid response in asthma is unknown. To examine airway microbiome composition in patients with…”
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Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial by Wenzel, Sally, Prof, Castro, Mario, MD, Corren, Jonathan, MD, Maspero, Jorge, MD, Wang, Lin, PhD, Zhang, Bingzhi, PhD, Pirozzi, Gianluca, MD, Sutherland, E Rand, MD, Evans, Robert R, PharmD, Joish, Vijay N, PhD, Eckert, Laurent, PhD, Graham, Neil M H, MD, Stahl, Neil, PhD, Yancopoulos, George D, MD, Louis-Tisserand, Mariana, MD, Teper, Ariel, MD

“…Summary Background Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody, inhibits interleukin-4 and interleukin-13 signalling, key…”
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Obesity and Asthma by Beuther, David A, Weiss, Scott T, Sutherland, E. Rand

“…Asthma and obesity are prevalent disorders, each with a significant public health impact, and a large and growing body of literature suggests an association…”
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CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease by Rennard, Stephen I, Dale, David C, Donohue, James F, Kanniess, Frank, Magnussen, Helgo, Sutherland, E Rand, Watz, Henrik, Lu, Susan, Stryszak, Paul, Rosenberg, Elizabeth, Staudinger, Heribert

“…An antagonist (MK-7123) of the cytokine receptor CXCR2 reduces neutrophil chemotaxis and thus may alleviate airway inflammation in chronic obstructive…”
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Clinical phenotypes of chronic obstructive pulmonary disease and asthma: Recent advances by Carolan, Brendan J., MD, Sutherland, E. Rand, MD, MPH

“…Asthma and chronic obstructive pulmonary disease (COPD) are prevalent obstructive lung diseases, both of which are characterized by airflow limitation…”
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Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial by Thaçi, Diamant, Prof, Simpson, Eric L, MD, Beck, Lisa A, Prof, Bieber, Thomas, Prof, Blauvelt, Andrew, MD, Papp, Kim, MD, Soong, Weily, MD, Worm, Margitta, Univ-Prof, Szepietowski, Jacek C, Prof, Sofen, Howard, MD, Kawashima, Makoto, Prof, Wu, Richard, PhD, Weinstein, Steven P, MD, Graham, Neil M H, MD, Pirozzi, Gianluca, MD, Teper, Ariel, MD, Sutherland, E Rand, MD, Mastey, Vera, MS, Stahl, Neil, PhD, Yancopoulos, George D, MD, Ardeleanu, Marius, MD

“…Summary Background Data from early-stage studies suggested that interleukin (IL)-4 and IL-13 are requisite drivers of atopic dermatitis, evidenced by marked…”
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Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD) by Simpson, Eric L., MD, MCR, Gadkari, Abhijit, PhD, Worm, Margitta, MD, Soong, Weily, MD, Blauvelt, Andrew, MD, MBA, Eckert, Laurent, PhD, Wu, Richard, PhD, Ardeleanu, Marius, MD, Graham, Neil M.H., MD, PhD, Pirozzi, Gianluca, MD, PhD, Sutherland, E. Rand, MD, MPH, Mastey, Vera, BPharm, MS

“…Background Moderate to severe atopic dermatitis (AD) is associated with substantial patient burden despite current therapies. Objective We sought to evaluate…”
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Body Mass and Glucocorticoid Response in Asthma by Sutherland, E. Rand, Goleva, Elena, Strand, Matthew, Beuther, David A, Leung, Donald Y. M

“…Obesity may alter glucocorticoid response in asthma. To evaluate the relationship between body mass index (BMI, kg/m(2)) and glucocorticoid response in…”
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Asthma and atypical bacterial infection by Sutherland, E Rand, Martin, Richard J

“…A growing body of basic and clinical science implicates the atypical bacterial pathogens Mycoplasma pneumoniae and Chlamydophila (formerly Chlamydia)…”
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Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma by Huang, Yvonne J., MD, Nelson, Craig E., PhD, Brodie, Eoin L., PhD, DeSantis, Todd Z., MS, Baek, Marshall S., BS, Liu, Jane, MS, Woyke, Tanja, PhD, Allgaier, Martin, PhD, Bristow, Jim, MD, Wiener-Kronish, Jeanine P., MD, Sutherland, E. Rand, MD, MPH, King, Tonya S., PhD, Icitovic, Nikolina, MAS, Martin, Richard J., MD, Calhoun, William J., MD, Castro, Mario, MD, Denlinger, Loren C., MD, PhD, DiMango, Emily, MD, Kraft, Monica, MD, Peters, Stephen P., MD, PhD, Wasserman, Stephen I., MD, Wechsler, Michael E., MD, Boushey, Homer A., MD, Lynch, Susan V., PhD

“…Background Improvement in lung function after macrolide antibiotic therapy has been attributed to reduction in bronchial infection by specific bacteria…”
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Predictors of rehospitalization and death after a severe exacerbation of COPD by McGhan, Ryan, Radcliff, Tiffany, Fish, Ron, Sutherland, E Rand, Welsh, Carolyn, Make, Barry

“…Patients who survive a severe exacerbation of COPD are at high risk of rehospitalization for COPD and death. The objective of this study was to determine…”
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Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment by Hall, Ian P, Fowler, Andrew V, Gupta, Abhya, Tetzlaff, Kay, Nivens, Michael C, Sarno, Maria, Finnigan, Helen A, Bateman, Eric D, Rand Sutherland, E

“…Abstract The prostaglandin D2 (PGD2 ) receptor, CRTH2, plays a role in allergic airway inflammation. The efficacy of BI 671800, a CRTH2 antagonist, was…”
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Cluster analysis of obesity and asthma phenotypes by Sutherland, E Rand, Goleva, Elena, King, Tonya S, Lehman, Erik, Stevens, Allen D, Jackson, Leisa P, Stream, Amanda R, Fahy, John V, Leung, Donald Y M

“…Asthma is a heterogeneous disease with variability among patients in characteristics such as lung function, symptoms and control, body weight, markers of…”
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Management of Chronic Obstructive Pulmonary Disease by Sutherland, E. Rand, Cherniack, Reuben M

“…The goals of therapy for chronic obstructive pulmonary disease include relieving symptoms, improving abnormal physiology, and limiting complications, including…”
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Is there a link between obesity and asthma? by Kim, Sang-Ha, Sutherland, E Rand, Gelfand, Erwin W

“…Increasing epidemiological data identify a link between obesity and asthma incidence and severity. Based on experimental data, it is possible that shared…”
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Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma by Ono, Emiko, Dutile, Stefanie, Kazani, Shamsah, Wechsler, Michael E, Yang, Jun, Hammock, Bruce D, Douda, David Nobuhiro, Tabet, Yacine, Khaddaj-Mallat, Rayan, Sirois, Marco, Sirois, Chantal, Rizcallah, Edmond, Rousseau, Eric, Martin, Richard, Sutherland, E Rand, Castro, Mario, Jarjour, Nizar N, Israel, Elliot, Levy, Bruce D

“…Severe asthma is characterized by airway inflammatory responses associated with aberrant metabolism of arachidonic acid. Lipoxins (LX) are arachidonate-derived…”
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A trial of clarithromycin for the treatment of suboptimally controlled asthma by Sutherland, E. Rand, MD, MPH, King, Tonya S., PhD, Icitovic, Nikolina, MAS, Ameredes, Bill T., PhD, Bleecker, Eugene, MD, Boushey, Homer A., MD, Calhoun, William J., MD, Castro, Mario, MD, MPH, Cherniack, Reuben M., MD, Chinchilli, Vernon M., PhD, Craig, Timothy J., DO, Denlinger, Loren, MD, PhD, DiMango, Emily A., MD, Fahy, John V., MD, Israel, Elliot, MD, Jarjour, Nizar, MD, Kraft, Monica, MD, Lazarus, Stephen C., MD, Lemanske, Robert F., MD, Peters, Stephen P., MD, PhD, Ramsdell, Joe, MD, Sorkness, Christine A., PharmD, Szefler, Stanley J., MD, Walter, Michael J., MD, Wasserman, Stephen I., MD, Wechsler, Michael E., MD, MMSc, Chu, Hong Wei, MD, Martin, Richard J., MD

“…Background PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma. Objective…”
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Predictors of response to tiotropium versus salmeterol in asthmatic adults by Peters, Stephen P., MD, PhD, Bleecker, Eugene R., MD, Kunselman, Susan J., MA, Icitovic, Nikolina, MAS, Moore, Wendy C., MD, Pascual, Rodolfo, MD, Ameredes, Bill T., PhD, Boushey, Homer A., MD, Calhoun, William J., MD, Castro, Mario, MD, Cherniack, Reuben M., MD, Craig, Timothy, DO, Denlinger, Loren C., MD, PhD, Engle, Linda L., BS, DiMango, Emily A., MD, Israel, Elliot, MD, Kraft, Monica, MD, Lazarus, Stephen C., MD, Lemanske, Robert F., MD, Lugogo, Njira, MD, Martin, Richard J., MD, Meyers, Deborah A., PhD, Ramsdell, Joe, MD, Sorkness, Christine A., PharmD, Sutherland, E. Rand, MD, Wasserman, Stephen I., MD, Walter, Michael J., MD, Wechsler, Michael E., MD, Chinchilli, Vernon M., PhD, Szefler, Stanley J., MD

“…Background Tiotropium has activity as an asthma controller. However, predictors of a positive response to tiotropium have not been described. Objective We…”
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