Search Results - "Sutherland, Duncan E. K"

Safety of Lutetium-177 prostate-specific membrane antigen-617 (PSMA-617) radioligand therapy in the setting of severe renal impairment: a case report and literature review by Sutherland, Duncan E. K., Kashyap, Raghava, Jackson, Price, Buteau, James P., Murphy, Declan G., Kelly, Brian, Spain, Lavinia, Sandhu, Shahneen, Azad, Arun A., Medhurst, Elizabeth, Kong, Grace, Hofman, Michael S.

“…Reported here is a case of rapidly progressive metastatic castration-resistant prostate cancer treated with [177Lu]Lu-PSMA-617 in the setting of severe renal…”
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Survival predictors of 177Lu-Dotatate peptide receptor radionuclide therapy (PRRT) in patients with progressive well-differentiated neuroendocrine tumors (NETS) by Swiha, Mina M., Sutherland, Duncan E. K., Sistani, Golmehr, Khatami, Alireza, Abazid, Rami M., Mujoomdar, Amol, Wiseman, Daniele P., Romsa, Jonathan G., Reid, Robert H., Laidley, David T.

“…Purpose 177 Lu-Dotatate is an emerging treatment modality for patients with unresectable or metastatic well-differentiated NETs. This study examines survival…”
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Metal Selectivity of the Escherichia coli Nickel Metallochaperone, SlyD by Kaluarachchi, Harini, Siebel, Judith F, Kaluarachchi-Duffy, Supipi, Krecisz, Sandra, Sutherland, Duncan E. K, Stillman, Martin J, Zamble, Deborah B

“…SlyD is a Ni(II)-binding protein that contributes to nickel homeostasis in Escherichia coli. The C-terminal domain of SlyD contains a rich variety of…”
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Noncooperative Metalation of Metallothionein 1a and Its Isolated Domains with Zinc by Sutherland, Duncan E. K, Summers, Kelly L, Stillman, Martin J

“…Mammalian metallothioneins (MTs) are a family of small cysteine-rich proteins capable of binding 7 Zn2+ or Cd2+ ions into two distinct domains: an N-terminal…”
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Single Domain Metallothioneins: Supermetalation of Human MT 1a by Sutherland, Duncan E. K, Willans, Mathew J, Stillman, Martin J

“…Metallothioneins are a family of small, cysteine rich proteins that have been implicated in a range of roles including toxic metal detoxification, protection…”
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Single-Domain Metallothioneins: Evidence of the Onset of Clustered Metal Binding Domains in Zn-rhMT 1a by Summers, Kelly L, Sutherland, Duncan E. K, Stillman, Martin J

“…Mammalian metallothioneins bind up to seven Zn2+ ions in two distinct domains: an N-terminal β-domain that binds three Zn2+ ions and a C-terminal α-domain that…”
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Challenging conventional wisdom: single domain metallothioneins by Sutherland, Duncan E. K, Stillman, Martin J

“…Metallothioneins (MT) are a family of small cysteine rich proteins that have been implicated in a range of roles including toxic metal detoxification,…”
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Efficacy of 177Lu-Dotatate Induction and Maintenance Therapy of Various Types of Neuroendocrine Tumors: A Phase II Registry Study by Sistani, Golmehr, Sutherland, Duncan E. K., Mujoomdar, Amol, Wiseman, Daniele P., Khatami, Alireza, Tsvetkova, Elena, Reid, Robert H., Laidley, David T.

“…Peptide receptor radionuclide therapy (PRRT) has been recently established as a treatment option for progressive gastro-entero-pancreatic neuroendocrine tumors…”
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The Ni(II)-Binding Properties of the Metallochaperone SlyD by Kaluarachchi, Harini, Sutherland, Duncan E. K, Young, Alex, Pickering, Ingrid J, Stillman, Martin J, Zamble, Deborah B

“…Metallochaperones are essential for the safe and targeted delivery of necessary yet toxic metal cofactors to their respective protein partners. In this study…”
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Supermetalation of the β Domain of Human Metallothionein 1a by Sutherland, Duncan E. K, Willans, Mathew J, Stillman, Martin J

“…Metallothionein has been implicated in a number of functions, including toxic metal detoxification, as a metal chaperone and in metal ion homeostasis. In this…”
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Prolonged response to vismodegib in a patient with systemic medulloblastoma metastases by Climans, Seth A, Macdonald, David R, Sutherland, Duncan EK, Mason, Warren P

“…Some patients with metastatic medulloblastoma can be successfully treated with targeted therapy. We report the case of a 42-year-old woman who was diagnosed…”
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Role of FDG PET/CT in Management of Patients with Prostate Cancer by Sutherland, Duncan E K, Azad, Arun A, Murphy, Declan G, Eapen, Renu S, Kostos, Louise, Hofman, Michael S

“…Prostate cancer is the second most common cancer in men worldwide. [ F]FDG PET/CT imaging, a well-known and effective technique for detecting malignancies, has…”
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The "magic numbers" of metallothionein by Sutherland, Duncan E K, Stillman, Martin J

“…Metallothioneins (MT) are a family of small cysteine rich proteins, which since their discovery in 1957, have been implicated in a range of roles including…”
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It’s a small world after all: A Canadian resident’s perspective on COVID-19 by Sutherland, Duncan E.K.

“…COVID-19 has infected millions of people, with an estimated total dead in the hundreds of thousands. This has significantly impacted health care, including who…”
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Stabilization of protein structure through [pi]-[pi] interaction in the second coordination sphere of pseudoazurin by Yamaguchi, Takahide, Nihei, Yuko, Sutherland, Duncan E K, Stillman, Martin J, Kohzuma, Takamitsu

“…Noncovalent, weak interactions in the second coordination sphere of the copper active site of Pseudoazurin (PAz) from Achromobacter cycloclastes were examined…”
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Stabilization of protein structure through π–π interaction in the second coordination sphere of pseudoazurin by Yamaguchi, Takahide, Nihei, Yuko, Sutherland, Duncan E. K., Stillman, Martin J., Kohzuma, Takamitsu

“…Noncovalent, weak interactions in the second coordination sphere of the copper active site of Pseudoazurin (PAz) from Achromobacter cycloclastes were examined…”
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Modeling the Zn2+ and Cd2+ metalation mechanism in mammalian metallothionein 1a by Sutherland, Duncan E.K., Summers, Kelly L., Stillman, Martin J.

“…[Display omitted] ► ESI-mass spectral data provide key information about the metalation mechanism of MT. ► Metal ion speciation as a function of metals added…”
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Cu(I) binding properties of a designed metalloprotein by Xie, Fei, Sutherland, Duncan E.K., Stillman, Martin J., Ogawa, Michael Y.

“…The Cu(I) binding properties of the designed peptide C16C19-GGY are reported. This peptide was designed to form an α-helical coiled-coil but modified to…”
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Modeling the Zn(2+) and Cd(2+) metalation mechanism in mammalian metallothionein 1a by Sutherland, Duncan E K, Summers, Kelly L, Stillman, Martin J

“…Mammalian metallothioneins (MTs) are a family of small cysteine rich proteins believed to have a number of physiological functions, including both metal ion…”
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Noncooperative cadmium(II) binding to human metallothionein 1a by Sutherland, Duncan E.K., Stillman, Martin J.

“…The two-domain (βα) mammalian metallothionein binds seven divalent metals, however, the binding mechanism is not well characterized and recent reports require…”
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