Search Results - "Sutherland, Claire L."

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors by Meininger, David, Zalameda, Leeanne, Liu, Yichin, Stepan, Lara P., Borges, Luis, McCarter, John D., Sutherland, Claire L.

“…Indoleamine 2,3-dioxygenase (IDO1) catalyzes the first step in tryptophan breakdown along the kynurenine pathway. Therapeutic inhibition of IDO1 is receiving…”
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Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity by Dunn, Claire, Chalupny, N Jan, Sutherland, Claire L, Dosch, Stephanie, Sivakumar, P V, Johnson, David C, Cosman, David

“…The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC)…”
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UL16-Binding Proteins, Novel MHC Class I-Related Proteins, Bind to NKG2D and Activate Multiple Signaling Pathways in Primary NK Cells by Sutherland, Claire L, Chalupny, N. Jan, Schooley, Kenneth, VandenBos, Tim, Kubin, Marek, Cosman, David

“…The UL16-binding proteins (ULBPs) are a novel family of MHC class I-related molecules that were identified as targets of the human CMV glycoprotein, UL16. We…”
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A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function by Armstrong, Allison P, Tometsko, Mark E, Glaccum, Moira, Sutherland, Claire L, Cosman, David, Dougall, William C

“…Signaling through receptor activator of nuclear factor-κB (RANK) is essential for the differentiation and activation of osteoclasts, the cell principally…”
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The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions by Sutherland, Claire L., Chalupny, N. Jan, Cosman, David

“…The UL16‐binding proteins (ULBPs) are a novel family of MHC class I‐related molecules (MICs) that were identified based on their ability to bind to the human…”
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Neuropathology of a Case With Fatal CAR T-Cell-Associated Cerebral Edema by Torre, Matthew, Solomon, Isaac H, Sutherland, Claire L, Nikiforow, Sarah, DeAngelo, Daniel J, Stone, Richard M, Vaitkevicius, Henrikas, Galinsky, Ilene A, Padera, Robert F, Trede, Nikolaus, Santagata, Sandro

“…Abstract Chimeric antigen receptor (CAR) T cells are a new and powerful class of cancer immunotherapeutics that have shown potential for the treatment of…”
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Expression of Trop2 Cell Surface Glycoprotein in Normal and Tumor Tissues: Potential Implications as a Cancer Therapeutic Target by Stepan, Lara P., Trueblood, Esther S., Hale, Kari, Babcook, John, Borges, Luis, Sutherland, Claire L.

“…Trop2 is a cell-surface glycoprotein reported to be overexpressed in various types of adenocarcinomas with minimal expression in normal tissues. Recent…”
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ULBPs, Novel MHC Class I–Related Molecules, Bind to CMV Glycoprotein UL16 and Stimulate NK Cytotoxicity through the NKG2D Receptor by Cosman, David, Müllberg, Jürgen, Sutherland, Claire L., Chin, Wilson, Armitage, Richard, Fanslow, William, Kubin, Marek, Chalupny, N.Jan

“…The human cytomegalovirus glycoprotein, UL16, binds to two members of a novel family of molecules, the ULBPs, and to the MHC class I homolog, MICB. The ULBPs…”
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ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15 by Sutherland, Claire L., Rabinovich, Brian, Chalupny, N. Jan, Brawand, Pierre, Miller, Robert, Cosman, David

“…ULBPs are human ligands for NKG2D, an activating receptor expressed on natural killer (NK) cells, NK1.1+ T cells, and T cells. ULBPs are expressed by a variety…”
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Dendritic cell survival and maturation are regulated by different signaling pathways by Rescigno, M, Martino, M, Sutherland, C L, Gold, M R, Ricciardi-Castagnoli, P

“…Although dendritic cell (DC) activation is a critical event for the induction of immune responses, the signaling pathways involved in this process have not…”
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ULBP4 is a novel ligand for human NKG2D by Jan Chalupny, N, Sutherland, Claire L, Lawrence, William A, Rein-Weston, Annie, Cosman, David

“…The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor…”
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Listeria monocytogenes Invasion of Epithelial Cells Requires the MEK-1/ERK-2 Mitogen-Activated Protein Kinase Pathway by TANG, P, SUTHERLAND, C. L, GOLD, M. R, FINLAY, B. B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Tumor gene signature associated with neurotoxicity in R/R B-ALL patients treated with JCAR015, a CD19-directed CAR T cell product by Olson, N. Eric, Ragan, Seamus P., Ponko, Stefan, Trede, Nikolaus S., Stern, Howard Marvin, Sutherland, Claire L.

“…Abstract only…”
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Pharmacokinetic, Pharmacodynamic and Blood Analytes Associated with Clinical Response and Safety in Relapsed/Refractory Aggressive B-NHL Patients Treated with JCAR017 by Heipel, Mark, Smith, Jeffrey, Brown, William, Karimi, Mandana, Xie, Benhuai, Li, Daniel, Albertson, Tina, Garcia, Jacob, Devries, Todd, Sutherland, Claire L

“…Introduction: JCAR017 is a CD19-directed 4-1BB CAR T cell product administered in a defined composition at a precise dose of CD8 and CD4 CAR T cells. TRANSCEND…”
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Predicting Clinical Response and Safety of JCAR017 in B-NHL Patients: Potential Importance of Tumor Microenvironment Biomarkers and CAR T-Cell Tumor Infiltration by Swanson, Christina, Do, Trevor, Merrigan, Samantha, Lonning, Shaparak, Merriam, Kim, Prentiss, Joshua, Sridar, Janani, Sutherland, Claire L, Xie, Benhuai, Pham, Minh, Li, Daniel, Albertson, Tina, Stern, Howard M, Moulis, Sharon

“…▪ Introduction: JCAR017 is a CD19-directed 4-1BB CAR T-cell product administered in a defined composition at a precise dose of CD8 and CD4 CAR T cells…”
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Patient Characteristics and Pre-Infusion Biomarkers of Inflammation Correlate with Clinical Outcomes after Treatment with the Defined Composition, CD19-Targeted CAR T Cell Product, JCAR017 by Siddiqi, Tanya, Abramson, Jeremy S., Li, Daniel, Brown, William, Devries, Todd, Dave, Kedar, Garcia, Jacob, Palomba, Maria Lia, Gordon, Leo I., Lunning, Matthew A., Arnason, Jon E., Wang, Michael, Forero-Torres, Andres, Maloney, David G., Albertson, Tina, Sutherland, Claire L

“…▪ Introduction JCAR017 is a CD19-directed 4-1BB CAR T cell product candidate administered in a defined composition at a precise dose of CD8 and CD4 CAR T…”
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Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor by Sutherland, CL, Heath, AW, Pelech, SL, Young, PR, Gold, MR

“…B cell antigen receptor (BCR)-induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40. We have used this cell line to…”
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An 11-amino acid sequence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun N-terminal kinase, activation of MAPKAP kinase-2, phosphorylation of I kappa B alpha, and protection of WEHI-231 cells from anti-IgM-induced growth arrest by Sutherland, C L, Krebs, D L, Gold, M R

“…We have previously shown that CD40 causes strong activation of the c-Jun N-terminal kinase (JNK), the p38 mitogen-activated protein kinases (MAPK) and MAPKAP…”
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Purification and identification of tyrosine-phosphorylated proteins from B lymphocytes stimulated through the antigen receptor by Gold, M R, Yungwirth, T, Sutherland, C L, Ingham, R J, Vianzon, D, Chiu, R, van Oostveen, I, Morrison, H D, Aebersold, R

“…The activation of protein tyrosine kinase (PTKs) and subsequent tyrosine phosphorylation of cellular proteins is a critical initial signal in the response of…”
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An 11-Amino Acid Sequence in the Cytoplasmic Domain of CD40 Is Sufficient for Activation of c-Jun N-Terminal Kinase, Activation of MAPKAP Kinase-2, Phosphorylation of I{kappa}B{alpha}, and Protection of WEHI-231 Cells from Anti-IgM-Induced Growth Arrest by Sutherland, Claire L, Krebs, Danielle L, Gold, Michael R

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