Tamoxifen citrate loaded biodegradable poly(sebacic acid-co- ricinoleic acid) microparticles, in vitro characterization

Tamoxifen citrate loaded biodegradable poly(sebacic acid-co- ricinoleic acid) microparticles, in vitro characterization

The aim of the present investigation was to develop biodegradable microparticles of the antineoplastic drug, tamoxifen citrate, for the treatment of breast cancer, using poly(sebacic acid-co-ricinoleic acid) 70:30 w/w as a drug carrier. Drug loaded microparticles were prepared by utilizing solvent d...

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Bibliographic Details
Published in:Journal of drug delivery science and technology Vol. 21; no. 5; pp. 417 - 422
Main Authors: Hiremath, J.G., Rudani, C.G., Suthar, R.V., Domb, A.J.
Format: Journal Article
Language:English
Published: Paris Elsevier B.V 2011
Editions de santé
Subjects:
Biodegradable
Biological and medical sciences
Breast cancer
General pharmacology
Medical sciences
Microparticles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Poly(sebacic acid-co-ricinoleic acid)
Tamoxifen citrate
Tamoxifen citrate
Breast cancer
Biodegradable
Poly(sebacic acid-co-ricinoleic acid)
Microparticles
Antineoplastic agent
Breast disease
Pharmaceutical technology
Biodegradability
Antiestrogen
Citrate
Antihormone
Malignant tumor
In vitro
Tamoxifene
Sebacic acid
Characterization
Mammary gland diseases
Selective estrogen receptor modulator
Microparticle
Non steroid compound
Cancer
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Summary:The aim of the present investigation was to develop biodegradable microparticles of the antineoplastic drug, tamoxifen citrate, for the treatment of breast cancer, using poly(sebacic acid-co-ricinoleic acid) 70:30 w/w as a drug carrier. Drug loaded microparticles were prepared by utilizing solvent displacement technique and characterized for particle size and distribution, surface morphology, drug physical state and crystalline nature, entrapment efficiency, drug loading and in vitro release characteristics. Spherical microparticles were obtained with a smooth surface and a mean particle size of 1.0-1.6 μm. The entrapped tamoxifen citrate in microparticles has no evidence of any chemical or physical interaction with polymer and drug was in the form of amorphous state. In vitro release studies showed zero order and Korsmeyer-Peppas model release being exhibited. A significant difference in sustaining capacity was seen in microparticles with different drug loading. Sustained release effect was more pronounced in microparticles prepared with loading level.
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ISSN:1773-2247
DOI:10.1016/S1773-2247(11)50067-X