Polymers used in pharmaceutical industry for oral delivery: insight to synthesis, structure–activity relationship, and recent applications

Polymers used in pharmaceutical industry for oral delivery: insight to synthesis, structure–activity relationship, and recent applications

For a long time, polymers have played a critical role in the pharmaceutical industry for developing safe, effective, and deliverable dosage forms. Among all the dosage forms oral dosage form remains the most widely used, prescribed, and produced ones. The present review articles comprehensively desc...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Vol. 81; no. 18; pp. 16373 - 16413
Main Authors: Mori, Dhaval, Dudhat, Kiran, Soniwala, Moinuddin, Parmar, Ramesh, Suthar, Devi, Jayani, Rutvi, Shah, Sunny, Borkhataria, Chetan, Patel, Kalpesh, Dudhrejiya, Ashwin
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2024
Springer Nature B.V
Subjects:
Cellulose acetate
Characterization and Evaluation of Materials
Chemical synthesis
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Dosage
Drug delivery systems
Drug dosages
Gels
Glucose
Hydrogen bonds
Industrial development
Microspheres
Organic Chemistry
Pharmaceutical industry
Pharmaceuticals
Physical Chemistry
Polymer Sciences
Polymers
Review Paper
Soft and Granular Matter
Tablets
Polymer
Synthetic polymers
Degree of substitution
Semi-synthetic cellulose
Cellulose
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Summary:For a long time, polymers have played a critical role in the pharmaceutical industry for developing safe, effective, and deliverable dosage forms. Among all the dosage forms oral dosage form remains the most widely used, prescribed, and produced ones. The present review articles comprehensively describe various natural, semi-synthetic, and synthetic polymers used to prepare oral solid dosage forms. Along with describing a method for isolation and preparation of all the polymers, this article also explains in detail the key physicochemical properties that make them suitable for the particular dosage form. The article specifically deals with the formulation of conventional tablets, sustained-release matrix tablets, solid dispersions, and other miscellaneous dosage forms such as microspheres and oral gels. Furthermore, the article also provides a detailed discussion of the factors that influence the selection of the appropriate polymer and formulation method. This review article is expected to be a valuable resource for researchers, scientists, and professionals in the pharmaceutical industry who are interested in using polymers for developing effective and safe oral solid dosage forms.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-024-05509-1