Search Results - "Suter, Scott R"

Structure-Guided Control of siRNA Off-Target Effects by Suter, Scott R, Sheu-Gruttadauria, Jessica, Schirle, Nicole T, Valenzuela, Rachel, Ball-Jones, Alexi A, Onizuka, Kazumitsu, MacRae, Ian J, Beal, Peter A

“…Short interfering RNAs (siRNAs) are promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA…”
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TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length by Hu, Tiannan, Suter, Scott R., Mumbleau, Madeline M., Beal, Peter A.

“…[Display omitted] Toll-like receptor 8 (TLR8) is an important component of the human innate immune system that recognizes single stranded RNA (ssRNA). Recent…”
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Guide Strand 3′-End Modifications Regulate siRNA Specificity by Valenzuela, Rachel A. P., Onizuka, Kazumitsu, Ball-Jones, Alexi A., Hu, Tiannan, Suter, Scott R., Beal, Peter A.

“…Short interfering RNA (siRNA)‐triggered gene knockdown through the RNA interference (RNAi) pathway is widely used to study gene function, and siRNA‐based…”
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Base Modification Strategies to Modulate Immune Stimulation by an siRNA by Valenzuela, Rachel Anne P., Suter, Scott R., Ball-Jones, Alexi A., Ibarra-Soza, José M., Zheng, Yuxuan, Beal, Peter A.

“…Immune stimulation triggered by siRNAs is one of the major challenges in the development of safe RNAi‐based therapeutics. Within an immunostimulatory siRNA…”
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Imaging Intracellular S‑Adenosyl Methionine Dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-Based Sensor by Li, Xing, Mo, Liuting, Litke, Jacob L, Dey, Sourav Kumar, Suter, Scott R, Jaffrey, Samie R

“…To understand the role of intracellular metabolites in cellular processes, it is important to measure the dynamics and fluxes of small molecules in living…”
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Ester modification at the 3′ end of anti-microRNA oligonucleotides increases potency of microRNA inhibition by Pham, Kevin M., Suter, Scott R., Lu, Shannon S., Beal, Peter A.

“…[Display omitted] MicroRNAs (miRNAs) are short noncoding RNAs that play a fundamental role in gene regulation. Deregulation of miRNA expression has a strong…”
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Imaging Intracellular SAM dynamics in Live Mammalian Cells with a Genetically Encoded Red Fluorescent RNA-based Sensor by Li, Xing, Mo, Liuting, Litke, Jacob L., Dey, Sourav Kumar, Suter, Scott R., Jaffrey, Samie R.

“…In order to understand the role of intracellular metabolites in cellular processes, it is important to measure the dynamics and fluxes of small molecules in…”
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