Search Results - "Sutcliffe, Diane J"

A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts by Escudero-Ferruz, Paula, Ontiveros, Neus, Cano-Estrada, Claudia, Sutcliffe, Diane J, Jinnah, H A, Torres, Rosa J, López, José M

“…Lesch-Nyhan disease (LND) is a severe neurological disorder caused by the genetic deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGprt), an…”
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Induced pluripotent stem cells from subjects with Lesch-Nyhan disease by Sutcliffe, Diane J., Dinasarapu, Ashok R., Visser, Jasper E., Hoed, Joery den, Seifar, Fatemeh, Joshi, Piyush, Ceballos-Picot, Irene, Sardar, Tejas, Hess, Ellen J., Sun, Yan V., Wen, Zhexing, Zwick, Michael E., Jinnah, H. A.

“…Lesch-Nyhan disease (LND) is an inherited disorder caused by pathogenic variants in the HPRT1 gene, which encodes the purine recycling enzyme…”
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Magnetic Targeting of Human Mesenchymal Stem Cells with Internalized Superparamagnetic Iron Oxide Nanoparticles by Landázuri, Natalia, Tong, Sheng, Suo, Jin, Joseph, Giji, Weiss, Daiana, Sutcliffe, Diane J., Giddens, Don P., Bao, Gang, Taylor, W. Robert

“…Cell therapies offer exciting new opportunities for effectively treating many human diseases. However, delivery of therapeutic cells by intravenous injection,…”
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Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease by López, José M., Outtrim, Esther L., Fu, Rong, Sutcliffe, Diane J., Torres, Rosa J., Jinnah, H. A.

“…Lesch-Nyhan disease (LND), caused by a deficient salvage purine pathway, is characterized by severe neurological manifestations and uric acid overproduction…”
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Striatal Subregion-selective Dysregulated Dopamine Receptor-mediated Intracellular Signaling in a Model of DOPA-responsive Dystonia by Roman, Kaitlyn M., Briscione, Maria A., Donsante, Yuping, Ingram, Jordan, Fan, Xueliang, Bernhard, Douglas, Campbell, Simone A., Downs, Anthony M., Gutman, David, Sardar, Tejas A., Bonno, Sofia Q., Sutcliffe, Diane J., Jinnah, H.A., Hess, Ellen J.

“…•Dopamine-mediated intracellular signal is dysregulated in dystonia.•Abnormal intracellular signaling was differentially regulated in striatal subregions.•ERK…”
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Exploration of potential immune mechanisms in cervical dystonia by Scorr, Laura M., Kilic-Berkmen, Gamze, Sutcliffe, Diane J., Dinasarapu, Ashok R., McKay, J. Lucas, Bagchi, Pritha, Powell, Michael D., Boss, Jeremy M., Cereb, Nezih, Little, Marian, Gragert, Loren, Hanfelt, John, McKeon, Andrew, Tyor, William, Jinnah, H.A.

“…Although there are many possible causes for cervical dystonia (CD), a specific etiology cannot be identified in most cases. Prior studies have suggested a…”
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Abnormalities of neural stem cells in Lesch-Nyhan disease by Dinasarapu, Ashok R., Sutcliffe, Diane J., Seifar, Fatemeh, Visser, Jasper E., Jinnah, H. A.

“…Lesch-Nyhan disease (LND) is a neurodevelopmental disorder caused by variants in the HPRT1 gene, which encodes the enzyme hypoxanthine-guanine phosphoribosyl…”
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Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis by Cribbs, Sushma K., Sutcliffe, Diane J., Taylor, William R., Rojas, Mauricio, Easley, Kirk A., Tang, Li, Brigham, Kenneth L., Martin, Greg S.

“…Purpose Endothelial dysfunction is a primary contributor to sepsis-related organ dysfunction and death. In sepsis animal models, endothelial progenitor cells…”
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Circulating proangiogenic cell activity is associated with cardiovascular disease risk by Mavromatis, Kreton, Aznaouridis, Konstantinos, Al Mheid, Ibhar, Veledar, Emir, Dhawan, Saurabh, Murrow, Jonathan R, Forghani, Zohreh, Sutcliffe, Diane J, Ghasemzadeh, Nima, Alexander, R Wayne, Taylor, W Robert, Quyyumi, Arshed A

“…Vascular injury mobilizes bone marrow-derived proangiogenic cells into the circulation, where these cells can facilitate vascular repair and new vessel…”
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Proangiogenic cell colonies grown in vitro from human peripheral blood mononuclear cells by Mavromatis, Kreton, Sutcliffe, Diane J, Joseph, Giji, Alexander, R Wayne, Waller, Edmund K, Quyyumi, Arshed A, Taylor, W Robert

“…Although multiple culture assays have been designed to identify endothelial progenitor cells (EPCs), the phenotype of cells grown in culture often remains…”
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Contributions of Purine Synthesis and Recycling During Brain Development: Relevance to Lesch Nyhan Disease (S39.009) by Seifar, Fatemeh, Sutcliffe, Diane J., Joshi, Piyush, Jinnah, Hyder. A.

“…Abstract only…”
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Striatal ERK is Activated in Response to L‐DOPA Administration in a Knock‐in Mouse Model of DOPA‐Responsive Dystonia by Briscione, Maria, Donsante, Christine, Fan, Xueliang, Campbell, Simone, Bernhard, Douglas, Downs, Anthony, Gutman, David, Sardar, Tejas, Shannon, Alec, Sutcliffe, Diane J., Jinnah, H.A., Hess, Ellen J.

“…Abnormal dopamine (DA) neurotransmission is associated with many dystonic disorders; however, the precise nature of the defects in DA transmission that result…”
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Abstract 1749: Endothelial Progenitor Cells and Vascular Endothelial Function Follow a Parallel Circadian Pattern by Mheid, Ibhar Al, Aznaouridis, Konstantinos, Patel, Riyaz, Shirazi, Farheen, Sutcliffe, Diane J, Taylor, W. R, Alexander, R. W, Quyyumi, Arshed

“…Abstract only Background: Endothelial Progenitor Cells (EPCs) are mobilized in response to endothelial injury and their counts correlate with endothelial…”
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Assessment of Cytogenetic Response to Folic Acid Deprivation in Rat Lymphocytes by B. Bhaskar Gollapudi, Diane J. Sutcliffe, Sinha, Anil K.

“…Rat lymphocyte cultures were initiated in minimal essential medium containing 0, 0.01, 1.0, or 10 mg/l of folic acid to investigate the influence of folic acid…”
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