Search Results - "Sussman, Robyn"

Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma by Bosse, Kristopher R., Raman, Pichai, Zhu, Zhongyu, Lane, Maria, Martinez, Daniel, Heitzeneder, Sabine, Rathi, Komal S., Kendsersky, Nathan M., Randall, Michael, Donovan, Laura, Morrissy, Sorana, Sussman, Robyn T., Zhelev, Doncho V., Feng, Yang, Wang, Yanping, Hwang, Jennifer, Lopez, Gonzalo, Harenza, Jo Lynne, Wei, Jun S., Pawel, Bruce, Bhatti, Tricia, Santi, Mariarita, Ganguly, Arupa, Khan, Javed, Marra, Marco A., Taylor, Michael D., Dimitrov, Dimiter S., Mackall, Crystal L., Maris, John M.

“…We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-surface molecules in neuroblastoma that meet criteria for optimal…”
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Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy by Sotillo, Elena, Barrett, David M, Black, Kathryn L, Bagashev, Asen, Oldridge, Derek, Wu, Glendon, Sussman, Robyn, Lanauze, Claudia, Ruella, Marco, Gazzara, Matthew R, Martinez, Nicole M, Harrington, Colleen T, Chung, Elaine Y, Perazzelli, Jessica, Hofmann, Ted J, Maude, Shannon L, Raman, Pichai, Barrera, Alejandro, Gill, Saar, Lacey, Simon F, Melenhorst, Jan J, Allman, David, Jacoby, Elad, Fry, Terry, Mackall, Crystal, Barash, Yoseph, Lynch, Kristen W, Maris, John M, Grupp, Stephan A, Thomas-Tikhonenko, Andrei

“…The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can be targeted with chimeric antigen receptor-armed T cells (CART-19), but…”
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Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism by Oldridge, Derek A., Wood, Andrew C., Weichert-Leahey, Nina, Crimmins, Ian, Sussman, Robyn, Winter, Cynthia, McDaniel, Lee D., Diamond, Maura, Hart, Lori S., Zhu, Shizhen, Durbin, Adam D., Abraham, Brian J., Anders, Lars, Tian, Lifeng, Zhang, Shile, Wei, Jun S., Khan, Javed, Bramlett, Kelli, Rahman, Nazneen, Capasso, Mario, Iolascon, Achille, Gerhard, Daniela S., Guidry Auvil, Jaime M., Young, Richard A., Hakonarson, Hakon, Diskin, Sharon J., Thomas Look, A., Maris, John M.

“…A causal variant is identified at the LMO1 oncogene locus that drives the genetic association of LMO1 with neuroblastoma susceptibility; the causal SNP…”
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Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation by Petruk, Svetlana, Cai, Jingli, Sussman, Robyn, Sun, Guizhi, Kovermann, Sina K., Mariani, Samanta A., Calabretta, Bruno, McMahon, Steven B., Brock, Hugh W., Iacovitti, Lorraine, Mazo, Alexander

“…Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs during cell differentiation…”
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Primary Pulmonary Myxoid Sarcoma and Myxoid Angiomatoid Fibrous Histiocytoma: A Unifying Continuum With Shared and Distinct Features by Gui, Hongxing, Sussman, Robyn T., Jian, Bo, Brooks, John S., Zhang, Paul J.L.

“…Primary pulmonary myxoid sarcoma (PPMS) is a recently reported, exceedingly rare low-grade lung neoplasm characterized by reticular/lace-like growth of spindle…”
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The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2) by Sussman, Robyn T., Stanek, Timothy J., Esteso, Paul, Gearhart, John D., Knudsen, Karen E., McMahon, Steven B.

“…Pluripotent embryonic stem cells (ESCs) undergo self-renewal until stimulated to differentiate along specific lineage pathways. Many of the transcriptional…”
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USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression by SCHRECENGOST, Randy S, DEAN, Jeffry L, VISAKORPI, Tapio, DEMARZO, Angelo M, MCMAHON, Steven B, KNUDSEN, Karen E, GOODWIN, Jonathan F, SCHIEWER, Matthew J, URBAN, Mark W, STANEK, Timothy J, SUSSMAN, Robyn T, HICKS, Jessica L, BIRBE, Ruth C, DRAGANOVA-TACHEVA, Rossitza A

“…Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase to cancer development and progression in a select group…”
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NTRK point mutations and their functional consequences by Rogers, Corey, Morrissette, Jennifer J.D., Sussman, Robyn T.

“…•NTRK point mutations can be oncogenic driver or acquired resistance mutations.•Some point mutations in NTRK genes respond to targeted…”
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Validation of a Next-Generation Sequencing Assay Targeting RNA for the Multiplexed Detection of Fusion Transcripts and Oncogenic Isoforms by Sussman, Robyn T, Oran, Amanda R, Paolillo, Carmela, Lieberman, David, Morrissette, Jennifer J D, Rosenbaum, Jason N

“…Next-generation sequencing is a high-throughput method for detecting genetic abnormalities and providing prognostic and therapeutic information for patients…”
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Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice by Davis, Adam R., Stone, Sara L., Oran, Amanda R., Sussman, Robyn T., Bhattacharyya, Siddharth, Morrissette, Jennifer J.D., Bagg, Adam

“…Massively parallel sequencing (MPS) has become a viable diagnostic tool to interrogate genetic profiles of numerous tumors but has yet to be routinely adopted…”
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ROS1 alterations as a potential driver of gliomas in infant, pediatric, and adult patients by Meredith, David M., Cooley, Linda D., Dubuc, Adrian, Morrissette, Jennifer, Sussman, Robyn T., Nasrallah, MacLean P., Rathbun, Pamela, Yap, Kai Lee, Wadhwani, Nitin, Bao, Liming, Wolff, Daynna J., Ida, Cristiane, Sukhanova, Madina, Horbinski, Craig, Jennings, Lawrence J., Farooqi, Midhat, Gener, Melissa, Ginn, Kevin, Kam, Kwok Ling, Sasaki, Koji, Kanagal-Shamanna, Rashmi, Alexandrescu, Sanda, Brat, Daniel, Lu, Xinyan

“…Gliomas harboring oncogenic ROS1 alterations are uncommon and primarily described in infants. Our goal was to characterize the clinicopathological features and…”
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Rapid and Automated Semiconductor-Based Next-Generation Sequencing for Simultaneous Detection of Somatic DNA and RNA Aberrations in Myeloid Neoplasms by Sande, Christopher M., Wu, Rui, Yang, Guang, Sussman, Robyn T., Bigdeli, Ashkan, Rushton, Chase, Chitturi, Akshay, Patel, Jay, Szankasi, Philippe, Morrissette, Jennifer J.D., Lim, Megan S., Elenitoba-Johnson, Kojo S.J.

“…Evaluation of suspected myeloid neoplasms involves testing for recurrent, diagnostically and therapeutically relevant genetic alterations. Current molecular…”
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Correction: Targeted massively parallel sequencing of mature lymphoid neoplasms: assessment of empirical application and diagnostic utility in routine clinical practice by Davis, Adam R., Stone, Sara L., Oran, Amanda R., Sussman, Robyn T., Bhattacharyya, Siddharth, Morrissette, Jennifer J. D., Bagg, Adam

“…A Correction to this paper has been published: https://doi.org/10.1038/s41379-020-00733-2…”
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Epigenomic profiling of neuroblastoma cell lines by Upton, Kristen, Modi, Apexa, Patel, Khushbu, Kendsersky, Nathan M., Conkrite, Karina L., Sussman, Robyn T., Way, Gregory P., Adams, Rebecca N., Sacks, Gregory I., Fortina, Paolo, Diskin, Sharon J., Maris, John M., Rokita, Jo Lynne

“…Understanding the aberrant transcriptional landscape of neuroblastoma is necessary to provide insight to the underlying influences of the initiation,…”
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CAMKV Is a Candidate Immunotherapeutic Target in MYCN Amplified Neuroblastoma by Sussman, Robyn T, Rokita, Jo Lynne, Huang, Kevin, Raman, Pichai, Rathi, Komal S, Martinez, Daniel, Bosse, Kristopher R, Lane, Maria, Hart, Lori S, Bhatti, Tricia, Pawel, Bruce, Maris, John M

“…We developed a computational pipeline designed to use RNA sequencing ( = 136) and gene expression profiling ( = 250) data from neuroblastoma tumors to identify…”
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Differential killing of CD56-expressing cells by drug-conjugated human antibodies targeting membrane-distal and membrane-proximal non-overlapping epitopes by Feng, Yang, Wang, Yanping, Zhu, Zhongyu, Li, Wei, Sussman, Robyn T, Randall, Michael, Bosse, Kristopher R, Maris, John M, Dimitrov, Dimiter S

“…CD56 (NCAM, neural cell adhesion molecule) is over-expressed in many tumor types, including neuroblastoma, multiple myeloma, small cell lung cancer, ovarian…”
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Interpretative differences of combined cytogenetic and molecular profiling highlights differences between MRC and ELN classifications of AML by Sussman, Robyn T., Manning, Bryan, Ackerman, Daniel, Bigdeli, Ashkan, Pammer, Paige, Velu, Priya D., Luger, Selina M., Bagg, Adam, Carroll, Martin, Morrissette, Jennifer J.D.

“…•Correlation of cytogenetic prognostic risk stratification with mutations in newly diagnosed de novo Acute Myeloid Leukemia.•Correlation of cytogenetic…”
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Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the Non-SP, a higher expression of c-Myc and TRAIL-receptor DR4 by Sussman, Robyn T., Ricci, M. Stacey, Hart, Lori S., Sun, Shi Yong, El-Deiry, Wafik S.

“…Cancer stem cells are resistant to chemotherapy and provide an important target for drug development. We found that, surprisingly, the dye-effluxing side…”
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Validation of a next-generation sequencing oncology panel optimized for low input DNA by Sussman, Robyn T., Shaffer, Sydney, Azzato, Elizabeth M., DeSloover, Daniel, Farooqi, Midhat S., Meyer, Anders, Lieberman, David B., Bigdeli, Ashkan, Paolillo, Carmela, Ganapathy, Karthik, Sukhadia, Shrey, Rosenbaum, Jason N., Daber, Robert D., Morrissette, Jennifer J.D.

“…•Hotspot panel for poor quality and low input oncology specimens.•Assay input DNA as low as 0.5-1 ng. One caveat of next-generation sequencing (NGS)-based…”
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Inhibition of the Single Downstream Target BAG1 Activates the Latent Apoptotic Potential of MYC by Zhang, Xiao-Yong, Pfeiffer, Harla K., Mellert, Hestia S., Stanek, Timothy J., Sussman, Robyn T., Kumari, Alpana, Yu, Duonan, Rigoutsos, Isidore, Thomas-Tikhonenko, Andrei, Seidel, Hans E., Chodosh, Lewis A., Packham, Graham, Baserga, Renato, McMahon, Steven B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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