Search Results - "Sussan, Thomas E"

Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model by Sussan, Thomas E, Gajghate, Sachin, Thimmulappa, Rajesh K, Ma, Jinfang, Kim, Jung-Hyun, Sudini, Kuladeep, Consolini, Nicola, Cormier, Stephania A, Lomnicki, Slawo, Hasan, Farhana, Pekosz, Andrew, Biswal, Shyam

“…Electronic cigarettes (E-cigs) have experienced sharp increases in popularity over the past five years due to many factors, including aggressive marketing,…”
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Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function by Sussan, Thomas E, Gajghate, Sachin, Chatterjee, Samit, Mandke, Pooja, McCormick, Sarah, Sudini, Kuladeep, Kumar, Sarvesh, Breysse, Patrick N, Diette, Gregory B, Sidhaye, Venkataramana K, Biswal, Shyam

“…Asthma development and pathogenesis are influenced by the interactions of airway epithelial cells and innate and adaptive immune cells in response to…”
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Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice by Sussan, Thomas E, Jun, Jonathan, Thimmulappa, Rajesh, Bedja, Djahida, Antero, Maria, Gabrielson, Kathleen L, Polotsky, Vsevolod Y, Biswal, Shyam

“…Oxidative stress and inflammation are two critical factors that drive the formation of plaques in atherosclerosis. Nrf2 is a redox-sensitive transcription…”
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Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4 by DRAGER, Luciano F, QIAOLING YAO, SCHWARTZ, Alan R, HALBERG, Nils, SCHERER, Philipp E, SEMENZA, Gregg L, POWELL, David R, POLOTSKY, Vsevolod Y, HERNANDEZ, Karen L, SHIN, Mi-Kyung, BEVANS-FONTI, Shannon, GAY, Jason, SUSSAN, Thomas E, JUN, Jonathan C, MYERS, Allen C, OLIVECRONA, Gunilla

“…Obstructive sleep apnea is a risk factor for dyslipidemia and atherosclerosis, which have been attributed to chronic intermittent hypoxia (CIH). Intermittent…”
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Targeting Nrf2 with the Triterpenoid CDDO-Imidazolide Attenuates Cigarette Smoke-Induced Emphysema and Cardiac Dysfunction in Mice by Sussan, Thomas E., Rangasamy, Tirumalai, Blake, David J., Malhotra, Deepti, El-Haddad, Hazim, Bedja, Djahida, Yates, Melinda S., Kombairaju, Ponvijay, Yamamoto, Masayuki, Liby, Karen T., Sporn, Michael B., Gabrielson, Kathleen L., Champion, Hunter C., Tuder, Rubin M., Kensler, Thomas W., Biswal, Shyam, Wogan, Gerald N.

“…Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a…”
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Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice by Fujihara, Masashi, Nagai, Norihiro, Sussan, Thomas E, Biswal, Shyam, Handa, James T

“…The purpose of this study was to determine whether mice exposed to chronic cigarette smoke develop features of early age-related macular degeneration (AMD)…”
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Electronic cigarette use behaviors and motivations among smokers and non-smokers by Sussan, Thomas E, Shahzad, Fatima G, Tabassum, Eefa, Cohen, Joanna E, Wise, Robert A, Blaha, Michael J, Holbrook, Janet T, Biswal, Shyam

“…The use of electronic cigarettes (EC) has risen exponentially over the past decade, including among never smokers, and ECs are now the most popular tobacco…”
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Source of biomass cooking fuel determines pulmonary response to household air pollution by Sussan, Thomas E, Ingole, Vijendra, Kim, Jung-Hyun, McCormick, Sarah, Negherbon, Jesse, Fallica, Jonathan, Akulian, Jason, Yarmus, Lonny, Feller-Kopman, David, Wills-Karp, Marsha, Horton, Maureen R, Breysse, Patrick N, Agrawal, Anurag, Juvekar, Sanjay, Salvi, Sundeep, Biswal, Shyam

“…Approximately 3 billion people-half the worldwide population-are exposed to extremely high concentrations of household air pollution due to the burning of…”
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Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity by Sussan, Thomas E., Sudini, Kuladeep, Talbot, C. Conover, Wang, Xiaobin, Wills-Karp, Marsha, Burd, Irina, Biswal, Shyam

“…Preterm birth (PTB) is the leading cause of neonatal mortality, and surviving infants are at increased risk for lifelong disabilities. Intrauterine…”
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Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke‐induced mouse model of COPD by Robison, Patrick, Sussan, Thomas E., Chen, Hegang, Biswal, Shyam, Schneider, Martin F., Hernández‐Ochoa, Erick O.

“…ABSTRACT Introduction Respiratory and locomotor skeletal muscle dysfunction are common findings in chronic obstructive pulmonary disease (COPD); however, the…”
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Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke by Thimmulappa, Rajesh K., Gang, Xing, Kim, Jung-Hyun, Sussan, Thomas E., Witztum, Joseph L., Biswal, Shyam

“…► Cigarette smoking impair macrophage bacterial phagocytosis but mechanisms unclear. ► Cigarette smoke (CS) exposure increase oxidized phospholipids (Ox-PLs)…”
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Correction to: electronic cigarette use behaviors and motivations among smokers and non-smokers by Sussan, Thomas E, Shahzad, Fatima G, Tabassum, Eefa, Cohen, Joanna E, Wise, Robert A, Blaha, Michael J, Holbrook, Janet T, Biswal, Shyam

“…After publication of the article [1], it has been brought to our attention that there is a funding acknowledgement missing. The authors would also like to…”
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Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle by Kombairaju, Ponvijay, Kerr, Jaclyn P, Roche, Joseph A, Pratt, Stephen J P, Lovering, Richard M, Sussan, Thomas E, Kim, Jung-Hyun, Shi, Guoli, Biswal, Shyam, Ward, Christopher W

“…Oxidative stress is a critical disease modifier in the muscular dystrophies. Recently, we discovered a pathway by which mechanical stretch activates NADPH…”
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Airborne Particulate Matter Induces Nonallergic Eosinophilic Sinonasal Inflammation in Mice by Ramanathan, Jr, Murugappan, London, Jr, Nyall R, Tharakan, Anuj, Surya, Nitya, Sussan, Thomas E, Rao, Xiaoquan, Lin, Sandra Y, Toskala, Elina, Rajagopalan, Sanjay, Biswal, Shyam

“…Exposure to airborne particulate matter (PM) has been linked to aggravation of respiratory symptoms, increased risk of cardiovascular disease, and all-cause…”
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Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome by Sussan, Thomas E, Yang, Annan, Li, Fu, Ostrowski, Michael C, Reeves, Roger H

“…Epidemiological studies spanning more than 50 yr reach conflicting conclusions as to whether there is a lower incidence of solid tumours in people with trisomy…”
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Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression by Sussan, Thomas E, Pletcher, Mathew T, Murakami, Yoshinori, Reeves, Roger H

“…Introduction of cDNA or genomic clones of the tumor suppressor in lung cancer 1 (TSLC1) gene into the non-small cell lung cancer line, A549, reverses…”
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Using Evidence Integration Techniques in the Development of Health-Based Occupational Exposure Levels by Lent, Emily May, Sussan, Thomas E., Leach, Glenn J., Johnson, Mark S.

“…Development of toxicology-based criteria such as occupational exposure levels (OELs) are rarely straightforward. This process requires a rigorous review of the…”
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Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome by Sussan, Thomas E., Yang, Annan, Li, Fu, Ostrowski, Michael C., Reeves, Roger H.

“…Down's syndrome cancers Some epidemiological studies have suggested that individuals with Down's syndrome (who carry three copies of chromosome 21, known as…”
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Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova‐induced sinonasal inflammation by London, Nyall R., Tharakan, Anuj, Mendiola, Michelle, Chen, Mengfei, Dobzanski, Alex, Sussan, Thomas E., Zaykaner, Michael, Han, Andrew H., Lane, Andrew P., Sidhaye, Venkataramana, Biswal, Shyam, Ramanathan, Murugappan

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Deletion of Nrf2 enhances susceptibility to eosinophilic sinonasal inflammation in a murine model of rhinosinusitis by London, Nyall R., Tharakan, Anuj, Mendiola, Michelle, Sussan, Thomas E., Chen, Mengfei, Dobzanski, Alex, Lane, Andrew P., Sidhaye, Venkataramana, Biswal, Shyam, Ramanathan, Murugappan

“…Background Oxidative stress exacerbates lower airway diseases including asthma and chronic obstructive pulmonary disease (COPD); however, its role in upper…”
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