Search Results - "Susorov, Denis"

Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM by Loveland, Anna B., Svidritskiy, Egor, Susorov, Denis, Lee, Soojin, Park, Alexander, Zvornicanin, Sarah, Demo, Gabriel, Gao, Fen-Biao, Korostelev, Andrei A.

“…Toxic dipeptide-repeat (DPR) proteins are produced from expanded G 4 C 2 repeats in the C9ORF72 gene, the most common genetic cause of amyotrophic lateral…”
Get full text

Eukaryotic translation elongation factor 2 (eEF2) catalyzes reverse translocation of the eukaryotic ribosome by Susorov, Denis, Zakharov, Nikita, Shuvalova, Ekaterina, Ivanov, Alexander, Egorova, Tatiana, Shuvalov, Alexey, Shatsky, Ivan N., Alkalaeva, Elena

“…During protein synthesis, a ribosome moves along the mRNA template and, using aminoacyl-tRNAs, decodes the template nucleotide triplets to assemble a protein…”
Get full text

Thermal unfolding of homodimers and heterodimers of different skeletal-muscle isoforms of tropomyosin by Matyushenko, Alexander M., Kleymenov, Sergey Y., Susorov, Denis S., Levitsky, Dmitrii I.

“…We applied differential scanning calorimetry (DSC) to investigate the structural properties of three isoforms of tropomyosin (Tpm), α, β, and γ, expressed from…”
Get full text

Structural and functional properties of αβ-heterodimers of tropomyosin with myopathic mutations Q147P and K49del in the β-chain by Matyushenko, Alexander M., Shchepkin, Daniil V., Susorov, Denis S., Nefedova, Victoria V., Kopylova, Galina V., Berg, Valentina Y., Kleymenov, Sergey Y., Levitsky, Dmitrii I.

“…Tropomyosin (Tpm) is an α-helical coiled-coil actin-binding protein that plays a key role in the Ca2+-regulated contraction of striated muscles. Two Tpm…”
Get full text

Upstream Open Reading Frames Located in the Leader of Protein Kinase Mζ mRNA Regulate Its Translation by Bal, Natalia V, Susorov, Denis, Chesnokova, Ekaterina, Kasianov, Artem, Mikhailova, Tatiana, Alkalaeva, Elena, Balaban, Pavel M, Kolosov, Peter

“…For protein synthesis that occurs locally in dendrites, the translational control mechanisms are much more important for neuronal functioning than the…”
Get full text

Termi-Luc: a versatile assay to monitor full-protein release from ribosomes by Susorov, Denis, Egri, Shawn, Korostelev, Andrei A

“…Termination of protein biosynthesis is an essential step of gene expression, during which a complete functional protein is released from the ribosome…”
Get full text

mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs) by Susorov, Denis, Echeverria, Dimas, Khvorova, Anastasia, Korostelev, Andrei A

“…Abstract Nonsense mutations account for >10% of human genetic disorders, including cystic fibrosis, Alagille syndrome, and Duchenne muscular dystrophy. A…”
Get full text

PABP enhances release factor recruitment and stop codon recognition during translation termination by Ivanov, Alexandr, Mikhailova, Tatyana, Eliseev, Boris, Yeramala, Lahari, Sokolova, Elizaveta, Susorov, Denis, Shuvalov, Alexey, Schaffitzel, Christiane, Alkalaeva, Elena

“…Poly(A)-binding protein (PABP) is a major component of the messenger RNA-protein complex. PABP is able to bind the poly(A) tail of mRNA, as well as translation…”
Get full text

RNA helicase DDX19 stabilizes ribosomal elongation and termination complexes by Mikhailova, Tatiana, Shuvalova, Ekaterina, Ivanov, Alexander, Susorov, Denis, Shuvalov, Alexey, Kolosov, Peter M, Alkalaeva, Elena

“…The human DEAD-box RNA-helicase DDX19 functions in mRNA export through the nuclear pore complex. The yeast homolog of this protein, Dbp5, has been reported to…”
Get full text

Stabilization of eukaryotic ribosomal termination complexes by deacylated tRNA by Susorov, Denis, Mikhailova, Tatiana, Ivanov, Alexander, Sokolova, Elizaveta, Alkalaeva, Elena

“…Stabilization of the ribosomal complexes plays an important role in translational control. Mechanisms of ribosome stabilization have been studied in detail for…”
Get full text

Structural and functional properties of αβ-heterodimers of tropomyosin with myopathic mutations Q147P and K49del in the β-chain by Matyushenko, Alexander M, Shchepkin, Daniil V, Susorov, Denis S, Nefedova, Victoria V, Kopylova, Galina V, Berg, Valentina Y, Kleymenov, Sergey Y, Levitsky, Dmitrii I

“…Tropomyosin (Tpm) is an α-helical coiled-coil actin-binding protein that plays a key role in the Ca -regulated contraction of striated muscles. Two Tpm…”
Get full text