Optimizing Production, Characterization, and In Vitro Behavior of Silymarin-Eudragit Electrosprayed Fiber for Anti-Inflammatory Effects: A Chemical Study

Inflammatory Bowel Disease (IBD) is a chronic condition that affects approximately 1.6 million Americans. While current polyphenols for treating IBD can be expensive and cause unwanted side effects, there is an opportunity regarding a new drug/polymer formulation using silymarin and an electrospray...

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Published in:	Bioengineering (Basel) Vol. 11; no. 9; p. 864
Main Authors:	Madiyar, Foram, Suskavcevic, Liam, Daugherty, Kaitlyn, Weldon, Alexis, Ghate, Sahil, O'Brien, Takara, Melendez, Isabel, Morgan, Karl, Boetcher, Sandra, Namilae, Lasya
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-09-2024 MDPI
Subjects:	Acids Anti-inflammatory diet Anti-inflammatory drugs Antioxidants Bioavailability Biopolymers Calorimetry Cellulose acetate Colon Cytokines Differential scanning calorimetry drug–polymer complex Electric fields electrospray Electrospraying Encapsulation Enzymes Flavonoids Fourier transforms Free radicals Growth factors Inflammatory bowel disease Inflammatory bowel diseases Infrared spectrophotometers Infrared spectroscopy Investigations Lipids Medical prognosis Microencapsulation Microfibers Nanoparticles Particle size Phytochemicals Polymers Polyphenols Scanning electron microscopy Side effects Silymarin Spectrophotometry Missouri drug–polymer complex silymarin electrospray microencapsulation inflammatory bowel disease
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Summary:	Inflammatory Bowel Disease (IBD) is a chronic condition that affects approximately 1.6 million Americans. While current polyphenols for treating IBD can be expensive and cause unwanted side effects, there is an opportunity regarding a new drug/polymer formulation using silymarin and an electrospray procedure. Silymarin is a naturally occurring polyphenolic flavonoid antioxidant that has shown promising results as a pharmacological agent due to its antioxidant and hepatoprotective characteristics. This study aims to produce a drug-polymer complex named the SILS100-Electrofiber complex, using an electrospray system. The vertical set-up of the electrospray system was optimized at a 1:10 of silymarin and Eudragit S100 polymer to enhance surface area and microfiber encapsulation. The SILS100-Electrofiber complex was evaluated using drug release kinetics via UV Spectrophotometry, Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Differential Scanning Calorimetry (DSC). Drug loading, apparent solubility, and antioxidant activity were also evaluated. The study was successful in creating fiber-like encapsulation of the silymarin drug with strand diameters ranging from 5-7 μm, with results showing greater silymarin release in Simulated Intestinal Fluid (SIF) compared to Simulated Gastric Fluid (SGF). Moving forward, this study aims to provide future insight into the formulation of drug-polymer complexes for IBD treatment and targeted drug release using electrospray and microencapsulation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2306-5354 2306-5354
DOI:	10.3390/bioengineering11090864