Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients

Abstract Interest exists in identifying the factors that specifically contribute to the increased prevalence of cardiovascular disease observed in psychiatric disease. The apolipoprotein-E (APOE) gene codes for a protein that has a key role in metabolism of cholesterol and triglycerides, with increa...

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Bibliographic Details
Published in:	European psychiatry Vol. 24; no. 7; pp. 456 - 463
Main Authors:	Clark, D, Skrobot, O.A, Adebiyi, I, Susce, M.T, de Leon, J, Blakemore, AI.F, Arranz, M.J
Format:	Journal Article
Language:	English
Published:	Paris Elsevier SAS 01-10-2009 Elsevier
Subjects:	Adult and adolescent clinical studies Alleles Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Antipsychotics APOE Apolipoproteins E - genetics Biological and medical sciences Blood and lymphatic vessels Body Mass Index Cardiology. Vascular system Cardiovascular disease Cardiovascular Diseases - genetics Diabetes Mellitus, Type 2 - genetics Genetic Carrier Screening Genetic Predisposition to Disease - genetics Genotype Homozygote Humans Hypercholesterolemia - genetics Hyperlipidemias - genetics Hypertension - genetics Internal Medicine Medical sciences Miscellaneous Neuropharmacology Obesity Obesity - genetics Pharmacology. Drug treatments Polymorphism, Genetic - genetics Polymorphism, Single Nucleotide - genetics Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Risk Factors Risperidone - adverse effects Risperidone - therapeutic use Schizophrenia Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia Obesity Antipsychotics Cardiovascular disease APOE Atypical antipsychotic Neuroleptic Psychotropic Pharmacotherapy Serotonine receptor Genetic determinism Psychosis Apolipoprotein E Cross sectional study Genetics Antagonist Risperidone Benzisoxazole derivatives Nutritional status Human Dopamine antagonist Serotonin antagonist Genetic variant Nutrition disorder Concomitant disease D2 Dopamine receptor Treatment Risk factor
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Summary:	Abstract Interest exists in identifying the factors that specifically contribute to the increased prevalence of cardiovascular disease observed in psychiatric disease. The apolipoprotein-E (APOE) gene codes for a protein that has a key role in metabolism of cholesterol and triglycerides, with increased levels of apoE found in specific areas of post-mortem schizophrenic brains. This study investigated whether apoE variants influence the prevalence of cardiovascular risk factors (obesity, diabetes and dyslipidaemia), in patients receiving antipsychotic treatment, due to extension of the risk seen in the general population, but also due to the role of the APOE gene in mediating antipsychotic-induced side effects. Seven polymorphisms (rs741780, rs483082, rs429358, rs7412, rs10119, rs439401 and rs405509) were genotyped in 427 American Caucasian patients who were either receiving, or had been prescribed risperidone. Our results support the hypothesis that APOE gene variants influence the prevalence of diabetes and possibly overweight in psychiatric patients. Unfortunately, due to the cross sectional nature of this study, the contribution of antipsychotic treatment was not determined. These associations warrant prospective study to assess interaction between APOE gene variants and the propensity of antipsychotics to induce cardiovascular risk factors.
ISSN:	0924-9338 1778-3585
DOI:	10.1016/j.eurpsy.2009.03.003