Search Results - "Susana Hernández-García"

Filanesib for the treatment of multiple myeloma by Algarín, Esperanza Macarena, Hernández-García, Susana, Garayoa, Mercedes, Ocio, Enrique M

“…: Kinesin spindle protein (KSP) is indispensable for the proper separation of spindle poles during mitosis. Importantly, this protein is expressed only in…”
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Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma by Algarín, Esperanza M, Díaz-Tejedor, Andrea, Mogollón, Pedro, Hernández-García, Susana, Corchete, Luis A, San-Segundo, Laura, Martín-Sánchez, Montserrat, González-Méndez, Lorena, Schoumacher, Marie, Banquet, Sebastien, Kraus-Berthier, Laurence, Kloos, Ioana, Derreal, Alix, Halilovic, Ensar, Maacke, Heiko, Gutiérrez, Norma C, Mateos, María-Victoria, Paíno, Teresa, Garayoa, Mercedes, Ocio, Enrique M

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The kinesin spindle protein inhibitor filanesib enhances the activity of pomalidomide and dexamethasone in multiple myeloma by Hernández-García, Susana, San-Segundo, Laura, González-Méndez, Lorena, Corchete, Luis A, Misiewicz-Krzeminska, Irena, Martín-Sánchez, Montserrat, López-Iglesias, Ana-Alicia, Algarín, Esperanza Macarena, Mogollón, Pedro, Díaz-Tejedor, Andrea, Paíno, Teresa, Tunquist, Brian, Mateos, María-Victoria, Gutiérrez, Norma C, Díaz-Rodriguez, Elena, Garayoa, Mercedes, Ocio, Enrique M

“…Kinesin spindle protein inhibition is known to be an effective therapeutic approach in several malignancies. Filanesib (ARRY-520), an inhibitor of this…”
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Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair by López-Iglesias, Ana-Alicia, Herrero, Ana B, Chesi, Marta, San-Segundo, Laura, González-Méndez, Lorena, Hernández-García, Susana, Misiewicz-Krzeminska, Irena, Quwaider, Dalia, Martín-Sánchez, Montserrat, Primo, Daniel, Paíno, Teresa, Bergsagel, P Leif, Mehrling, Thomas, González-Díaz, Marcos, San-Miguel, Jesús F, Mateos, María-Victoria, Gutiérrez, Norma C, Garayoa, Mercedes, Ocio, Enrique M

“…Despite recent advances in the treatment of multiple myeloma (MM), the prognosis of most patients remains poor, and resistance to traditional and new drugs…”
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Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone by López-Iglesias, Ana-Alicia, González-Méndez, Lorena, San-Segundo, Laura, Herrero, Ana B, Hernández-García, Susana, Martín-Sánchez, Montserrat, Gutiérrez, Norma C, Paíno, Teresa, Avilés, Pablo, Mateos, María-Victoria, San-Miguel, Jesús F, Garayoa, Mercedes, Ocio, Enrique M

“…Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment…”
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Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer by Hernández-García, Susana, González, Verena, Sanz, Eduardo, Pandiella, Atanasio

“…One of the most aggressive breast cancer subtypes includes tumors with high expression of HER2. Gene expression and functional studies have shown a link…”
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Antitumoral effect of Ocoxin on acute myeloid leukemia by Díaz-Rodríguez, Elena, Hernández-García, Susana, Sanz, Eduardo, Pandiella, Atanasio

“…Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy whose incidence is growing in developed countries. In the relapse setting, very…”
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Physical training in chronic heart failure: pathophysiology and clinical evolution by Rivas Estany, Eduardo, Hernández García, Susana

“…Chronic heart failure has become one of the main global health problems; 23 million people suffer from this disease worldwide and age of onset has varied…”
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Protein Translation Inhibition is Involved in the Activity of the Pan-PIM Kinase Inhibitor PIM447 in Combination with Pomalidomide-Dexamethasone in Multiple Myeloma by Paíno, Teresa, González-Méndez, Lorena, San-Segundo, Laura, Corchete, Luis A., Hernández-García, Susana, Díaz-Tejedor, Andrea, Algarín, Esperanza M., Mogollón, Pedro, Martín-Sánchez, Montserrat, Gutiérrez, Norma C., Mateos, María-Victoria, Garayoa, Mercedes, Ocio, Enrique M.

“…Background: Proviral Insertion site for Moloney murine leukemia virus (PIM) kinases are overexpressed in hematologic malignancies, including multiple myeloma…”
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Antimyeloma Action of the Multikinase Inhibitor TG02 by Álvarez-Fernández, Stela, Hernández-García, Susana, Chen, Xi, Ocio, Enrique M., Paiva, Bruno, Meshow, Kay R., Cheatham, Lynn A., Burrows, Francis, San Miguel, Jesús F., Pandiella, Atanasio

“…Abstract 4062 Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable, despite recent advances in its treatment…”
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Acadesine Inhibits Proliferation and Induces Apoptosis In Multiple Myeloma Cells, and Synergizes with Standard of Care Antimyeloma Agents by Hernández-García, Susana, de Frias, Mercè, Campàs, Clara, Paiva, Bruno, Ocio, Enrique M., Miguel, Jesús F. San, Pandiella, Atanasio

“…Abstract 5023 Multiple myeloma (MM) is a malignancy characterized by the accumulation of plasma cells. The disease represents the second most common…”
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Fase de convalecencia en la rehabilitación cardíaca. Protocolo de actuación by Hernández García, Susana

“…La fase de convalecencia de la rehabilitación cardíaca tiene como propósito fundamental mejorar la capacidad funcional y fomentar un cambio del estilo de vida…”
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Rehabilitación cardiovascular y su efecto en la calidad de vida luego de intervencionismo coronario percutáneo by Andrade Ruiz, Henry, Rivas Estany, Eduardo, Hernández García, Susana, Campos Vera, Nelson Alfredo, Rodriguez Nande, Lidia, Castillo Diez, Elisa

“…Evaluar los efectos de la rehabilitación cardiovascular en la calidad de vida después del intervencionismo coronario percutáneo en la provincia de Manabí,…”
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Efecto del entrenamiento físico en pacientes con insuficiencia cardiaca crónica y fracción de eyección del ventrículo izquierdo deprimida by Peña Bofill, Vanessa, Rivas Estany, Eduardo, Hernández García, Susana, Sorio Valdés, Biolkis, Mustelier Oquendo, José Á, Larrinaga Sandrino, Vanessa, Rodriguez Nande, Lidia, Campos Vera, Nelson Alfredo

“…La utilización del entrenamiento de resistencia a la fuerza muscular en pacientes con insuficiencia cardiaca crónica y fracción de eyección deprimida (IC-FED)…”
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Fase hospitalaria de la rehabilitación cardíaca. Protocolo para la cirugía cardíaca by Prendes Lago, Elisabeth, Rivas Estany, Eduardo, Hernández García, Susana, Mustelier Oquendo, José Á

“…Cardiac rehabilitation in the hospitalization phase, in patients scheduled for surgery, has progressed over the years. Based on the knowledge and scientific…”
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Abstract 1291: The novel c-MYC inhibitor IDP-121 exhibits strong anti-myeloma effect by Krzeminski, Patryk, González-Méndez, Lorena, Segundo, Laura San, Mogollón, Pedro, Diaz, Andrea, Hernández-García, Susana, Algarín, Macarena, Martín-Sánchez, Montserrat, Cochete, Luis, Paino, Teresa, Esteban, Santiago, Nevola, Laura, Gutiérrez, Norma C., Mateos, Mª-Victoria, Garayoa, Mercedes, Ocio, Enrique M.

“…Multiple myeloma (MM) is a blood malignancy having its origin in differentiated B cells.1 The overall survival of MM patients has clearly improved with the use…”
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The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care by Paíno, Teresa, Garcia-Gomez, Antonio, González-Méndez, Lorena, San-Segundo, Laura, Hernández-García, Susana, López-Iglesias, Ana-Alicia, Algarín, Esperanza M, Martín-Sánchez, Montserrat, Corbacho, David, Ortiz-de-Solorzano, Carlos, Corchete, Luis A, Gutiérrez, Norma C, Maetos, María-Victoria, Garayoa, Mercedes, Ocio, Enrique M

“…PIM kinases are a family of serine/threonine kinases recently proposed as therapeutic targets in oncology. In the present work, we have investigated the…”
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Antimyeloma Effect of the Simultaneous Inhibition of MCL-1 (with S63845) and BCL-2 (with Venetoclax) in the Presence of the Microenvironment by Algarín, Esperanza M, Díaz-Tejedor, Andrea, Mogollón, Pedro, Hernández-García, Susana, Corchete, Luis, San-Segundo, Laura, Martín-Sánchez, Montserrat, González-Méndez, Lorena, Schoumacher, Marie, Banquet, Sébastien, Kraus-Berthier, Laurence, Kloos, Ioana, Halilovic, Ensar, Maacke, Heiko, Gutierrez, Norma C., Mateos, Maria-Victoria, Paíno, Teresa, Garayoa, Mercedes, Ocio, Enrique M.

“…Background: Venetoclax is a BCL-2 inhibitor particularly effective in patients with multiple myeloma (MM) harboring the t(11;14). However, resistance to…”
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Evaluación funcional de un programa de entrenamiento físico en pacientes infartados con disfunción sistólica severa del ventrículo izquierdo by Eduardo Rivas Estany, Nelson Campos Vera, José Barrera Sarduy, Susana Hernández García, Alexander Valdés Martín, Vanessa Peña Bofill, Elizabeth Prendes Lago

“…Resumen: Objetivo: Evaluar la factibilidad y los efectos sobre la capacidad funcional de un programa de entrenamiento físico supervisado, aplicado en pacientes…”
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Mechanisms Underlying the Synergistic Interaction of Filanesib with Pomalidomide and Dexamethasone (FPD) in Multiple Myeloma by Hernández-García, Susana, San-Segundo, Laura, González-Méndez, Lorena, Martín-Sánchez, Montserrat, Corchete, Luis A, Paíno, Teresa, López-Iglesias, Ana Alicia, Algarín, Esperanza Macarena, Garayoa, Mercedes, Tunquist, Brian, Gutierrez, Norma C, Mateos, Maria-Victoria, Ocio, Enrique M

“…Introduction: Filanesib (ARRY-520) is a novel inhibitor of the "kinesin spindle protein" (KSP), which has demonstrated efficacy in heavily pretreated patients…”
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