Search Results - "Susan Powell"

Sensorimotor gating deficits in “two-hit” models of schizophrenia risk factors by Khan, Asma, Powell, Susan B.

“…Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the…”
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The Relevance of Animal Models of Social Isolation and Social Motivation for Understanding Schizophrenia: Review and Future Directions by Powell, Susan B, Swerdlow, Neal R

“…Abstract Background and Hypotheses Social dysfunction in schizophrenia includes symptoms of withdrawal and deficits in social skills, social cognition, and…”
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C‐Reactive Protein: Marker of risk for post‐traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery by Friend, Samantha F., Nachnani, Rahul, Powell, Susan B., Risbrough, Victoria B.

“…Increasing evidence indicates that inflammation plays a role in PTSD and stress disorder pathophysiology. PTSD is consistently associated with higher…”
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Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model by Naviaux, Robert K, Zolkipli, Zarazuela, Wang, Lin, Nakayama, Tomohiro, Naviaux, Jane C, Le, Thuy P, Schuchbauer, Michael A, Rogac, Mihael, Tang, Qingbo, Dugan, Laura L, Powell, Susan B

“…Autism spectrum disorders (ASDs) are caused by both genetic and environmental factors. Mitochondria act to connect genes and environment by regulating…”
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Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia by Young, Jared W, Powell, Susan B, Risbrough, Victoria, Marston, Hugh M, Geyer, Mark A

“…Cognitive deficits in schizophrenia are among the core symptoms of the disease, correlate with functional outcome, and are not well treated with current…”
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Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model by Lai, Jessica IChi, Porcu, Alessandra, Romoli, Benedetto, Keisler, Maria, Manfredsson, Fredric P, Powell, Susan B, Dulcis, Davide

“…Previous work revealed an inverse correlation between tobacco smoking and Parkinson's disease (PD) that is associated with nicotine-induced neuroprotection of…”
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Behavioral and neurochemical consequences of cortical oxidative stress on parvalbumin-interneuron maturation in rodent models of schizophrenia by Powell, Susan B., Sejnowski, Terrence J., Behrens, M. Margarita

“…Oxidative stress, in response to the activation of the superoxide-producing enzyme Nox2, has been implicated in the schizophrenia-like behavioral dysfunction…”
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Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex by Amodeo, Dionisio A., Lai, Chi-Yu, Hassan, Omron, Mukamel, Eran A., Behrens, M. Margarita, Powell, Susan B.

“…Epidemiological studies suggest that the risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia is increased by prenatal…”
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Chronic presence of blood circulating anti-NMDAR1 autoantibodies impairs cognitive function in mice by Yue, William, Caldwell, Sorana, Risbrough, Victoria, Powell, Susan, Zhou, Xianjin

“…High titers of anti-NMDAR1 autoantibodies in brain cause anti-NMDAR1 encephalitis that displays psychiatric symptoms of schizophrenia and/or other psychiatric…”
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Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models by Deslauriers, Jessica, Powell, Susan B., Risbrough, Victoria B

“…•Animal models support role for peripheral and central immune signaling in anxiety/fear behavior.•Futures studies must address how specific immune mechanisms…”
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Prepulse inhibition and genetic mouse models of schizophrenia by Powell, Susan B., Zhou, Xianjin, Geyer, Mark A.

“…Mutant mouse models related to schizophrenia have been based primarily on the pathophysiology of schizophrenia, the known effects of antipsychotic drugs, and…”
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Acute serotonin 2A receptor activation impairs behavioral flexibility in mice by Amodeo, Dionisio A., Hassan, Omron, Klein, Landon, Halberstadt, Adam L., Powell, Susan B.

“…Serotonin 2A (5-HT2A) receptors are the primary site of action of hallucinogenic drugs and the target of atypical antipsychotics. 5-HT2A receptors are also…”
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Perioperative outcomes after laparoscopic cholecystectomy in elderly patients: a systematic review and meta-analysis by Kamarajah, Sivesh K., Karri, Santhosh, Bundred, James R., Evans, Richard P. T., Lin, Aaron, Kew, Tania, Ekeozor, Chinenye, Powell, Susan L., Singh, Pritam, Griffiths, Ewen A.

“…Background Laparoscopic cholecystectomy is increasingly performed in an ever ageing population; however, the risks are poorly quantified. The study aims to…”
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Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice by Halberstadt, Adam L, Koedood, Liselore, Powell, Susan B, Geyer, Mark A

“…Psilocin (4-hydroxy-N,N-dimethyltryptamine) is a hallucinogen that acts as an agonist at 5-HT1A, 5-HT2A, and 5-HT2C receptors. Psilocin is the active…”
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The novel ketamine analog methoxetamine produces dissociative-like behavioral effects in rodents by Halberstadt, Adam L., Slepak, Natalia, Hyun, James, Buell, Mahalah R., Powell, Susan B.

“…Rationale Methoxetamine (MXE) is a ketamine analog sold online that has been subject to widespread abuse for its dissociative and hallucinogenic effects…”
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Role of the 5-HT2A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice by Halberstadt, Adam L., Powell, Susan B., Geyer, Mark A.

“…The 5-HT2A receptor mediates the effects of serotonergic hallucinogens and may play a role in the pathophysiology of certain psychiatric disorders, including…”
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Role of Toll-like receptor 4 signaling in mast cell-mediated migraine pain pathway by Ramachandran, Roshni, Wang, Zhenping, Saavedra, Christian, DiNardo, Anna, Corr, Maripat, Powell, Susan B, Yaksh, Tony L

“…Degranulation of meningeal mast cells leading to the sensitization of trigeminal vascular afferent processing is believed to be one of the mechanisms…”
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Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models by Leffler, Abba E., Kuryatov, Alexander, Zebroski, Henry A., Powell, Susan R., Filipenko, Petr, Hussein, Adel K., Gorson, Juliette, Heizmann, Anna, Lyskov, Sergey, Tsien, Richard W., Poget, Sébastien F., Nicke, Annette, Lindstrom, Jon, Rudy, Bernardo, Bonneau, Richard, Holford, Mandë

“…Venom peptide toxins such as conotoxins play a critical role in the characterization of nicotinic acetylcholine receptor (nAChR) structure and function and…”
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Models of neurodevelopmental abnormalities in schizophrenia by Powell, Susan B

“…The neurodevelopmental hypothesis of schizophrenia asserts that the underlying pathology of schizophrenia has its roots in brain development and that these…”
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Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model by Naviaux, Jane C, Wang, Lin, Li, Kefeng, Bright, A Taylor, Alaynick, William A, Williams, Kenneth R, Powell, Susan B, Naviaux, Robert K

“…This study was designed to test a new approach to drug treatment of autism spectrum disorders (ASDs) in the Fragile X (Fmr1) knockout mouse model. We used…”
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