Search Results - "Susan L Welkos"

Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b by Terra, Jill K, Cote, Christopher K, France, Bryan, Jenkins, Amy L, Bozue, Joel A, Welkos, Susan L, LeVine, Steven M, Bradley, Kenneth A

“…Pathogenesis of Bacillus anthracis is associated with the production of lethal toxin (LT), which activates the murine Nalp1b/Nlrp1b inflammasome and induces…”
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Characterization of Burkholderia pseudomallei Strains Using a Murine Intraperitoneal Infection Model and In Vitro Macrophage Assays by Welkos, Susan L, Klimko, Christopher P, Kern, Steven J, Bearss, Jeremy J, Bozue, Joel A, Bernhards, Robert C, Trevino, Sylvia R, Waag, David M, Amemiya, Kei, Worsham, Patricia L, Cote, Christopher K

“…Burkholderia pseudomallei, the etiologic agent of melioidosis, is a gram-negative facultative intracellular bacterium. This bacterium is endemic in Southeast…”
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A Unique Set of the Burkholderia Collagen-Like Proteins Provides Insight into Pathogenesis, Genome Evolution and Niche Adaptation, and Infection Detection by Bachert, Beth A, Choi, Soo J, Snyder, Anna K, Rio, Rita V M, Durney, Brandon C, Holland, Lisa A, Amemiya, Kei, Welkos, Susan L, Bozue, Joel A, Cote, Christopher K, Berisio, Rita, Lukomski, Slawomir

“…Burkholderia pseudomallei and Burkholderia mallei, classified as category B priority pathogens, are significant human and animal pathogens that are highly…”
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Evaluation of two different vaccine platforms for immunization against melioidosis and glanders by Biryukov, Sergei S., Cote, Christopher K., Klimko, Christopher P., Dankmeyer, Jennifer L., Rill, Nathaniel O., Shoe, Jennifer L., Hunter, Melissa, Shamsuddin, Zain, Velez, Ivan, Hedrick, Zander M., Rosario-Acevedo, Raysa, Talyansky, Yuli, Schmidt, Lindsey K., Orne, Caitlyn E., Fetterer, David P., Burtnick, Mary N., Brett, Paul J., Welkos, Susan L., DeShazer, David

“…Burkholderia pseudomallei and the closely related species, Burkholderia mallei , produce similar multifaceted diseases which range from rapidly fatal to…”
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Characterization of pathogenesis of and immune response to Burkholderia pseudomallei K96243 using both inhalational and intraperitoneal infection models in BALB/c and C57BL/6 mice by Bearss, Jeremy J, Hunter, Melissa, Dankmeyer, Jennifer L, Fritts, Kristen A, Klimko, Christopher P, Weaver, Chris H, Shoe, Jennifer L, Quirk, Avery V, Toothman, Ronald G, Webster, Wendy M, Fetterer, David P, Bozue, Joel A, Worsham, Patricia L, Welkos, Susan L, Amemiya, Kei, Cote, Christopher K

“…Burkholderia pseudomallei, the etiologic agent of melioidosis, is a Gram negative bacterium designated as a Tier 1 threat. This bacterium is known to be…”
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Disease progression in mice exposed to low-doses of aerosolized clinical isolates of Burkholderia pseudomallei by Trevino, Sylvia R, Klimko, Christopher P, Reed, Matthew C, Aponte-Cuadrado, Michael J, Hunter, Melissa, Shoe, Jennifer L, Meyer, Joshua R, Dankmeyer, Jennifer L, Biryukov, Sergei S, Quirk, Avery V, Fritts, Kristen A, Kern, Steven J, Fetterer, David P, Kohler, Lara J, Toothman, Ronald G, Bozue, Joel A, Schellhase, Christopher W, Kreiselmeier, Norman, Daye, Sharon P, Welkos, Susan L, Soffler, Carl, Worsham, Patricia L, Waag, David M, Amemiya, Kei, Cote, Christopher K

“…Mouse models have been essential to generate supporting data for the research of infectious diseases. Burkholderia pseudomallei, the etiological agent of…”
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Roles of Macrophages and Neutrophils in the Early Host Response to Bacillus anthracis Spores in a Mouse Model of Infection by Cote, Christopher K, Van Rooijen, Nico, Welkos, Susan L

“…The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We…”
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Efficacy of Treatment with the Antibiotic Novobiocin against Infection with Bacillus anthracis or Burkholderia pseudomallei by Klimko, Christopher P, Welkos, Susan L, Shoe, Jennifer L, Mou, Sherry, Hunter, Melissa, Rill, Nathaniel O, DeShazer, David, Cote, Christopher K

“…The microbial pathogens and are unrelated bacteria, yet both are the etiologic agents of naturally occurring diseases in animals and humans and are classified…”
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Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei by Amemiya, Kei, Dankmeyer, Jennifer L, Bearss, Jeremy J, Zeng, Xiankun, Stonier, Spencer W, Soffler, Carl, Cote, Christopher K, Welkos, Susan L, Fetterer, David P, Chance, Taylor B, Trevino, Sylvia R, Worsham, Patricia L, Waag, David M

“…Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia…”
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Anthrax Toxins in Context of Bacillus anthracis Spores and Spore Germination by Cote, Christopher K, Welkos, Susan L

“…The interaction of anthrax toxin or toxin components with B. anthracis spores has been demonstrated. Germinating spores can produce significant amounts of…”
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Interrogation of the Burkholderia pseudomallei genome to address differential virulence among isolates by Challacombe, Jean F, Stubben, Chris J, Klimko, Christopher P, Welkos, Susan L, Kern, Steven J, Bozue, Joel A, Worsham, Patricia L, Cote, Christopher K, Wolfe, Daniel N

“…Infection by the Gram-negative pathogen Burkholderia pseudomallei results in the disease melioidosis, acquired from the environment in parts of southeast Asia…”
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Protection Elicited by Attenuated Live Yersinia pestis Vaccine Strains against Lethal Infection with Virulent Y. pestis by Cote, Christopher K, Biryukov, Sergei S, Klimko, Christopher P, Shoe, Jennifer L, Hunter, Melissa, Rosario-Acevedo, Raysa, Fetterer, David P, Moody, Krishna L, Meyer, Joshua R, Rill, Nathaniel O, Dankmeyer, Jennifer L, Worsham, Patricia L, Bozue, Joel A, Welkos, Susan L

“…The etiologic agent of plague, , is a globally distributed pathogen which poses both a natural and adversarial threat. Due largely to the rapid course and high…”
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Bacillus anthracis Spores of the bclA Mutant Exhibit Increased Adherence to Epithelial Cells, Fibroblasts, and Endothelial Cells but Not to Macrophages by Bozue, Joel, Moody, Krishna L, Cote, Christopher K, Stiles, Bradley G, Friedlander, Arthur M, Welkos, Susan L, Hale, Martha L

“…Bacillus anthracis is the causative agent of anthrax, and the spore form of the bacterium represents the infectious particle introduced into a host. The spore…”
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Roles of the Bacillus anthracis Spore Protein ExsK in Exosporium Maturation and Germination by SEVERSON, Kari M, MALLOZZI, Michael, BOZUE, Joel, WELKOS, Susan L, COTE, Christopher K, KNIGHT, Katherine L, DRIKS, Adam

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Immunization of Mice with Formalin-Inactivated Spores from Avirulent Bacillus cereus Strains Provides Significant Protection from Challenge with Bacillus anthracis Ames by Vergis, James M, Cote, Christopher K, Bozue, Joel, Alem, Farhang, Ventura, Christy L, Welkos, Susan L, O'Brien, Alison D

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The Impact of Age and Sex on Mouse Models of Melioidosis by Klimko, Christopher P, Treviño, Sylvia R, Moreau, Alicia M, Cuadrado, Michael J Aponte, Meyer, Joshua R, Fetterer, David P, Welkos, Susan L, Worsham, Patricia L, Kreiselmeier, Norman, Soffler, Carl, Cote, Christopher K

“…Mouse models have been used to generate critical data for many infectious diseases. In the case of , mouse models have been invaluable for bacterial…”
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Laser Scanning Confocal Microscopy Was Used to Validate the Presence of Burkholderia Pseudomallei or B. Mallei in Formalin-Fixed Paraffin Embedded Tissues by Amemiya, Kei, Zeng, Xiankun, Bearss, Jeremy J, Cote, Christopher K, Soffler, Carl, Bernhards, Robert C, Dankmeyer, Jennifer L, Ribot, Wilson J, Trevino, Sylvia R, Welkos, Susan L, Worsham, Patricia L, Waag, David M

“…and are Gram-negative, facultative intracellular bacteria that cause melioidosis and glanders, respectively. Currently, there are no vaccines for these two…”
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Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis by Terra, Jill K, France, Bryan, Cote, Christopher K, Jenkins, Amy, Bozue, Joel A, Welkos, Susan L, Bhargava, Ragini, Ho, Chi-Lee, Mehrabian, Margarete, Pan, Calvin, Lusis, Aldons J, Davis, Richard C, LeVine, Steven M, Bradley, Kenneth A

“…Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence…”
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Combinations of early generation antibiotics and antimicrobial peptides are effective against a broad spectrum of bacterial biothreat agents by Cote, Christopher K., Blanco, Irma I., Hunter, Melissa, Shoe, Jennifer L., Klimko, Christopher P., Panchal, Rekha G., Welkos, Susan L.

“…The misuse of infectious disease pathogens as agents of deliberate attack on civilians and military personnel is a serious national security concern, which is…”
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Venezuelan Equine Encephalitis Virus-Vectored Vaccines Protect Mice against Anthrax Spore Challenge by LEE, John S, HADJIPANAYIS, Angela G, WELKOS, Susan L

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