Search Results - "Susan J. Atkinson"

Individual Timp Deficiencies Differentially Impact Pro-MMP-2 Activation by English, Jane L., Kassiri, Zamaneh, Koskivirta, Ilpo, Atkinson, Susan J., Di Grappa, Marco, Soloway, Paul D., Nagase, Hideaki, Vuorio, Eero, Murphy, Gillian, Khokha, Rama

“…Membrane-type matrix metalloproteinases (MT-MMPs) have emerged as key enzymes in tumor cell biology. The importance of MT1-MMP, in particular, is highlighted…”
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The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition by Rapti, Magdalini, Atkinson, Susan J, Lee, Meng-Huee, Trim, Andrew, Moss, Marcia, Murphy, Gillian

“…ADAM (a disintegrin and metalloproteinase) 10 is a key member of the ADAM family of disintegrin and metalloproteinases which process membrane-associated…”
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Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing by Gilliver, Stephen C, Ruckshanthi, Jayalath P D, Atkinson, Susan J, Ashcroft, Gillian S

“…Excessive proteolytic activity is a feature of chronic wounds such as venous ulcers, in which resolution of the inflammatory response fails and restorative…”
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Early detection of risk of reading difficulties using a working memory assessment battery by Atkinson, Susan J., Martin, Colin R.

“…Research suggests a role for aspects of the working memory system in reading. While much of the evidence points to a role for working memory capacity and the…”
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MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells by Atkinson, Susan J, Roghi, Christian, Murphy, Gillian

“…The hemopexin-like domain of membrane-type matrix metalloproteinase-1 (MT1-MMP) enables MT1-MMP to form oligomers that facilitate the activation of pro-matrix…”
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Examining the expectations of early years' teachers in the U.A.E. regarding a successful start to school for children with and without special educational needs by Takriti, Rachel A., Elhoweris, Hala, Atkinson, Susan J.

“…Starting school has been shown to correlate with later school outcomes. The success of the transition of special educational needs (SEN) pupils depends on the…”
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Teachers' perceptions of successful transition to school for children with and without Downs Syndrome in the UAE and England by Atkinson, Susan J., Takriti, Rachel A., Elhoweris, Hala

“…The experience of transition into school has been shown to correlate with later school outcomes, with a successful experience resulting in later positive…”
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Teachers' expectations of children with Down Syndrome starting school in the United Arab Emirates or United Kingdom by Takriti, Rachel A., Atkinson, Susan J., Elhoweris, Hala

“…Starting school has been shown to correlate with later school outcomes. Teachers working in early years' settings either in the United Arab Emirates (UAE) or…”
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MT1-MMP on the cell surface causes focal degradation of gelatin films by d'Ortho, Marie-Pia, Stanton, Heather, Butler, Michael, Atkinson, Susan J, Murphy, Gillian, Hembry, Rosalind M

“…The membrane-type matrix metalloproteinases (MT-MMPs) are a subclass of the matrix metalloproteinase (MMP) family which uniquely possess a C-terminal…”
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Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain by Patterson, Margaret L, Atkinson, Susan J, Knäuper, Vera, Murphy, Gillian

“…In view of the essential role of the hemopexin domain of the traditional interstitial collagenases, MMP-1, -8, -13 and MT1-MMP (MMP-14), in determining…”
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Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes (∗) by Atkinson, Susan J., Crabbe, Thomas, Cowell, Susan, Ward, Robin V., Butler, Michael J., Sato, Hiroshi, Seiki, Motoharu, Reynolds, John J., Murphy, Gillian

“…Membrane-type matrix metalloproteinase (MT-MMP) messenger RNA and protein expression were shown to be elevated in human fibroblasts following treatment with…”
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Assessment of gelatinase expression and activity in articular cartilage by Hembry, Rosalind M, Atkinson, Susan J, Murphy, Gillian

“…Two methods for the assessment of the expression of gelatinases A and B, MMP-2 and MMP-9, in articular cartilage are described. Immunohistochemical analysis of…”
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A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs by Rossello, Armando, Nuti, Elisa, Catalani, Maria Pia, Carelli, Paolo, Orlandini, Elisabetta, Rapposelli, Simona, Tuccinardi, Tiziano, Atkinson, Susan J., Murphy, Gillian, Balsamo, Aldo

“…Starting from the potent MMP-2/MMP-14 inhibitor ( R)- 1 we describe new dimeric compounds of type 2, which are able to give an inhibitor–enzyme interaction…”
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Perivascular Cells Regulate Endothelial Membrane Type-1 Matrix Metalloproteinase Activity by Lafleur, Marc A., Forsyth, Peter A., Atkinson, Susan J., Murphy, Gillian, Edwards, Dylan R.

“…Angiogenic stimuli selectively induced expression of membrane type-1 matrix metalloproteinase (MT1-MMP) transcripts and protein in human umbilical vein…”
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Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species by LAFLEUR, Marc A., HOLLENBERG, Morley D., ATKINSON, Susan J., KNÄUPER, Vera, MURPHY, Gillian, EDWARDS, Dylan R.

“…Thrombin, a critical enzyme in the coagulation cascade, has also been associated with angiogenesis and activation of the zymogen form of matrix…”
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Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes by Ward, R V, Atkinson, S J, Slocombe, P M, Docherty, A J, Reynolds, J J, Murphy, G

“…We report that monolayers of human fibroblasts stimulated with concanavalin A were able to activate 72 kDa progelatinase but not 95 kDa progelatinase. The…”
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The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation by Will, Horst, Atkinson, Susan J., Butler, Georgina S., Smith, Bryan, Murphy, Gillian

“…It has been proposed that the cell-mediated activation of progelatinase A requires binding of the C-terminal domain of the proenzyme to a membrane-associated…”
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The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A by Butler, Georgina S., Butler, Michael J., Atkinson, Susan J., Will, Horst, Tamura, Tatsuya, van Westrum, Steven Schade, Crabbe, Thomas, Clements, John, d'Ortho, Marie-Pia, Murphy, Gillian

“…We have used C-terminal domain mutants to further define the role of interactions of progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in…”
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The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3 by Will, H, Atkinson, S J, Butler, G S, Smith, B, Murphy, G

“…It has been proposed that the cell-mediated activation of progelatinase A requires binding of the C-terminal domain of the proenzyme to a membrane-associated…”
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The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study by Butler, G S, Butler, M J, Atkinson, S J, Will, H, Tamura, T, Schade van Westrum, S, Crabbe, T, Clements, J, d'Ortho, M P, Murphy, G

“…We have used C-terminal domain mutants to further define the role of interactions of progelatinase A and membrane type 1 matrix metalloproteinase (MT1 MMP) in…”
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