Search Results - "Surve, Chinmay R."

A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis by Surve, Chinmay R., Lehmann, David, Smrcka, Alan V.

“…Our laboratory has identified a number of small molecules that bind to G protein βγ subunits (Gβγ) by competing for peptide binding to the Gβγ “hot spot.”…”
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A novel neuregulin - jagged1 paracrine loop in breast cancer transendothelial migration by Cabrera, Ramon M, Mao, Serena P H, Surve, Chinmay R, Condeelis, John S, Segall, Jeffrey E

“…The interaction of breast cancer cells with other cells in the tumor microenvironment plays an important role in metastasis. Invasion and intravasation, two…”
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Live tumor imaging shows macrophage induction and TMEM-mediated enrichment of cancer stem cells during metastatic dissemination by Sharma, Ved P., Tang, Binwu, Wang, Yarong, Duran, Camille L., Karagiannis, George S., Xue, Emily A., Entenberg, David, Borriello, Lucia, Coste, Anouchka, Eddy, Robert J., Kim, Gina, Ye, Xianjun, Jones, Joan G., Grunblatt, Eli, Agi, Nathan, Roy, Sweta, Bandyopadhyaya, Gargi, Adler, Esther, Surve, Chinmay R., Esposito, Dominic, Goswami, Sumanta, Segall, Jeffrey E., Guo, Wenjun, Condeelis, John S., Wakefield, Lalage M., Oktay, Maja H.

“…Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. Here, we…”
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Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ by Surve, Chinmay R, To, Jesi Y, Malik, Sundeep, Kim, Minsoo, Smrcka, Alan V

“…Activation of the Gi family of heterotrimeric guanine nucleotide-binding proteins (G proteins) releases βγ subunits, which are the major transducers of…”
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MenaINV dysregulates cortactin phosphorylation to promote invadopodium maturation by Weidmann, Maxwell D., Surve, Chinmay R., Eddy, Robert J., Chen, Xiaoming, Gertler, Frank B., Sharma, Ved P., Condeelis, John S.

“…Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the…”
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Abstract 976: Regulation of breast tumor metastasis by the dynamic interaction between the TMEM macrophage, tumor, and endothelial cells by Surve, Chinmay R., Harney, Allison, Wang, Yarong, Chen, Xiaoming, Sharma, Ved, Stanley, Richard, Oktay, Maja, Condeelis, John

“…Abstract Tumor cell intravasation is an essential step in the metastatic cascade, but its exact mechanism is not completely understood. We have previously…”
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Abstract 372: Macrophage contact-dependent stemness induction and progressive CSC enrichment during metastatic dissemination in breast cancer by Sharma, Ved P., Wang, Yarong, Tang, Binwu, Karagiannis, George S., Xue, Emily A., Entenberg, David, Borriello, Lucia, Coste, Anouchka, Jones, Joan G., Surve, Chinmay R., Esposito, Dominic, Oktay, Maja H., Wakefield, Lalage M., Condeelis, John S.

“…Abstract Background: Cancer stem cells (CSCs) play an important role during metastatic progression of breast cancer. However, little is known, at the single…”
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Abstract 972: Direct observation in living tumors shows macrophage-dependent induction and dissemination of cancer stem cells in breast cancer by Sharma, Ved P., Wang, Yarong, Tang, Binwu, Karagiannis, George S., Xue, Emily A., Entenberg, David, Borriello, Lucia, Coste, Anouchka, Surve, Chinmay R., Esposito, Dominic, Oktay, Maja H., Wakefield, Lalage M., Condeelis, John S.

“…Abstract Cancer stem cells (CSCs) play an important role during metastatic progression of breast cancer. However, the in vivo properties and dynamic behavior…”
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Abstract 898: Elucidation of the molecular mechanism of MenaINV expression, invadopodium maturation and tumor cell intravasation during breast cancer dissemination by TMEM by Weidmann, Maxwell D., Surve, Chinmay R., Pignatelli, Jeanine, Bravo-Cordero, Javier J., Karagiannis, George S., Oktay, Maja H., Condeelis, John S.

“…Abstract Numerous clinical studies have identified Tumor MicroEnvironment of Metastasis (TMEM) and MenaCalc as distinct but functionally interrelated…”
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Characterization of a Peptide Modulator of Gβγ Signaling Derived from Adenylyl Cyclase Type 2 by Velasquez, Monica Soto, Surve, Chinmay R., Perez, Minervo, Parker, Laurie L., Smrcka, Alan V., Watts, Val J.

“…Abstract only The objective of this study was to use a vector minigene strategy to explore the inhibitory action of a previously identified 20‐mer peptide on…”
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Mena INV dysregulates cortactin phosphorylation to promote invadopodium maturation by Weidmann, Maxwell D, Surve, Chinmay R, Eddy, Robert J, Chen, Xiaoming, Gertler, Frank B, Sharma, Ved P, Condeelis, John S

“…Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the…”
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