Search Results - "Surti, Neha"

The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity by Seigal, Benjamin A, Connors, William H, Fraley, Andrew, Borzilleri, Robert M, Carter, Percy H, Emanuel, Stuart L, Fargnoli, Joseph, Kim, Kyoung, Lei, Ming, Naglich, Joseph G, Pokross, Matthew E, Posy, Shana L, Shen, Henry, Surti, Neha, Talbott, Randy, Zhang, Yong, Terrett, Nicholas K

“…Affinity selection screening of macrocycle libraries derived from DNA-programmed chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound…”
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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain by Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

“…Effective treatment of chronic pain, in particular neuropathic pain, without the side effects that often accompany currently available treatment options is an…”
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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors by Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

“…Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified as a therapeutic target for the potential treatment of…”
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Conversion of carbazole carboxamide based reversible inhibitors of Bruton’s tyrosine kinase (BTK) into potent, selective irreversible inhibitors in the carbazole, tetrahydrocarbazole, and a new 2,3-dimethylindole series by Liu, Qingjie, Batt, Douglas G., Chaudhry, Charu, Lippy, Jonathan S., Pattoli, Mark A., Surti, Neha, Xu, Songmei, Carter, Percy H., Burke, James R., Tino, Joseph A.

“…[Display omitted] •Electrophilic groups increased potency and selectivity of carbazole BTK inhibitors.•Related indole analogs retained this potency and further…”
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Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton’s tyrosine kinase (BTK) and Janus kinase 2 (JAK2) by Liu, Qingjie, Batt, Douglas G., Lippy, Jonathan S., Surti, Neha, Tebben, Andrew J., Muckelbauer, Jodi K., Chen, Lin, An, Yongmi, Chang, Chiehying, Pokross, Matt, Yang, Zheng, Wang, Haiqing, Burke, James R., Carter, Percy H., Tino, Joseph A.

“…[Display omitted] Four series of disubstituted carbazole-1-carboxamides were designed and synthesised as inhibitors of Bruton’s tyrosine kinase (BTK). 4,7- and…”
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Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases by Shi, Qing, Tebben, Andrew, Dyckman, Alaric J., Li, Hedy, Liu, Chunjian, Lin, James, Spergel, Steve, Burke, James R., McIntyre, Kim W., Olini, Gilbert C., Strnad, Joann, Surti, Neha, Muckelbauer, Jodi K., Chang, Chiehying, An, Yongmi, Cheng, Lin, Ruan, Qian, Leftheris, Katerina, Carter, Percy H., Tino, Joseph, De Lucca, George V.

“…Investigation of various heterocyclic core isosteres of imidazopyrazines 1 &2 yielded purine derivatives 3 &8 as potent and selective BTK inhibitors…”
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Leveraging the IncuCyte Technology for Higher-Throughput and Automated Chemotaxis Assays for Target Validation and Compound Characterization by Chen, Jing, Ribeiro, Bert, Li, Han, Myer, Larnie, Chase, Peter, Surti, Neha, Lippy, Jonathan, Zhang, Litao, Cvijic, Mary Ellen

“…Chemotaxis is the directional movement of cells in response to a chemical stimulus and is vital for many physiological processes, including immune responses,…”
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Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging by Shou, Wilson Z, Gerritz, Samuel W, Harden, David, Lawrence, R Michael, Chase, Peter, Chin, Jefferson, Surti, Neha, Lippy, Jonathan S, Weller, Harold N, Nielsen, Julia, Weerakoon, Darshani

“…Hits from high-throughput screening (HTS) assays are typically evaluated using cheminformatics and/or empirical approaches before a decision for follow-up…”
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