Stereoselective syntheses of siphonarienal and siphonarienone

[Display omitted] The asymmetric total synthesis of marine polypropionate natural products siphonarienal and siphonarienone has been achieved from a common precursor 3. The key transformations of this synthesis are the diastereoselective oxidative kinetic resolution, Wittig olefination, Grignard rea...

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Bibliographic Details
Published in:	Tetrahedron: asymmetry Vol. 26; no. 17; pp. 885 - 890
Main Authors:	Ghanty, Supriya, Suresh Kumar, Chinta Krinda, Reddy, B.V. Subba
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 15-09-2015
Online Access:	Get full text
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Summary:	[Display omitted] The asymmetric total synthesis of marine polypropionate natural products siphonarienal and siphonarienone has been achieved from a common precursor 3. The key transformations of this synthesis are the diastereoselective oxidative kinetic resolution, Wittig olefination, Grignard reaction, and Evans asymmetric alkylation for the installation of a third stereogenic center of the target molecules from commercially available starting materials.
ISSN:	0957-4166 1362-511X
DOI:	10.1016/j.tetasy.2015.07.001