Search Results - "Suresh, Bharathi"

CYLD destabilizes NoxO1 protein by promoting ubiquitination and regulates prostate cancer progression by Haq, Saba, Sarodaya, Neha, Karapurkar, Janardhan Keshav, Suresh, Bharathi, Jo, Jung Ki, Singh, Vijai, Bae, Yun Soo, Kim, Kye-Seong, Ramakrishna, Suresh

“…The NADPH oxidase (Nox) family of enzymes is solely dedicated in the generation of reactive oxygen species (ROS). ROS generated by Nox are involved in multiple…”
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Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer by Das, Soumyadip, Chandrasekaran, Arun Pandian, Suresh, Bharathi, Haq, Saba, Kang, Jae-Hyeok, Lee, Su-Jae, Kim, Jaewon, Kim, Jaesang, Lee, Sanghyuk, Kim, Hyongbum Henry, Kim, Kye-Seong, Ramakrishna, Suresh

“…Conventional screening methods for deubiquitinating enzymes (DUBs) have important limitations. A loss-of-function study based on the knockout of DUB genes in…”
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming by Ramakrishna, Suresh, Kim, Kye-Seong, Lee, Junwon, Suresh, Bharathi

“…Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must…”
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Protein Degradation and the Pathologic Basis of Phenylketonuria and Hereditary Tyrosinemia by Sarodaya, Neha, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh

“…A delicate intracellular balance among protein synthesis, folding, and degradation is essential to maintaining protein homeostasis or proteostasis, and it is…”
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USP48 Governs Cell Cycle Progression by Regulating the Protein Level of Aurora B by Antao, Ainsley Mike, Kaushal, Kamini, Das, Soumyadip, Singh, Vijai, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh

“…Deubiquitinating enzymes play key roles in the precise modulation of Aurora B—an essential cell cycle regulator. The expression of Aurora B increases before…”
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Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes by Chandrasekaran, Arun Pandian, Suresh, Bharathi, Kim, Hyongbum (Henry), Kim, Kye‐Seong, Ramakrishna, Suresh

“…Post‐translational modification by ubiquitin molecules is a key regulatory process for stem cell fate determination. Ubiquitination and deubiquitination are…”
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Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis by Chandrasekaran, Arun Pandian, Woo, Sang Hyeon, Sarodaya, Neha, Rhie, Byung Ho, Tyagi, Apoorvi, Das, Soumyadip, Suresh, Bharathi, Ko, Na Re, Oh, Seung Jun, Kim, Kye-Seong, Ramakrishna, Suresh

“…Cell division cycle 25A (Cdc25A) is a dual-specificity phosphatase that is overexpressed in several cancer cells and promotes tumorigenesis. In normal cells,…”
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CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis by Karapurkar, Janardhan Keshav, Kim, Min-Seong, Colaco, Jencia Carminha, Suresh, Bharathi, Sarodaya, Neha, Kim, Dong-Ho, Park, Chang-Hwan, Hong, Seok-Ho, Kim, Kye-Seong, Ramakrishna, Suresh

“…The repressor element-1 silencing transcription factor (REST), a master transcriptional repressor, is essential for maintenance, self-renewal, and…”
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E3 Ubiquitin Ligase APC/CCdh1 Regulation of Phenylalanine Hydroxylase Stability and Function by Tyagi, Apoorvi, Sarodaya, Neha, Kaushal, Kamini, Chandrasekaran, Arun Pandian, Antao, Ainsley Mike, Suresh, Bharathi, Rhie, Byung Ho, Kim, Kye Seong, Ramakrishna, Suresh

“…Phenylketonuria (PKU) is an autosomal recessive metabolic disorder caused by the dysfunction of the enzyme phenylalanine hydroxylase (PAH). Alterations in the…”
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E3 Ubiquitin Ligase APC/CCdh1 Negatively Regulates FAH Protein Stability by Promoting Its Polyubiquitination by Kaushal, Kamini, Woo, Sang Hyeon, Tyagi, Apoorvi, Kim, Dong Ha, Suresh, Bharathi, Kim, Kye-Seong, Ramakrishna, Suresh

“…Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the…”
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Ubiquitin Specific Protease 29 Functions as an Oncogene Promoting Tumorigenesis in Colorectal Carcinoma by Chandrasekaran, Arun Pandian, Suresh, Bharathi, Sarodaya, Neha, Ko, Na-Re, Oh, Seung-Jun, Kim, Kye-Seong, Ramakrishna, Suresh

“…Colorectal carcinoma is the third foremost cause of cancer-related deaths and accounts for 5.8% of all deaths globally. The molecular mechanisms of colon…”
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Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruption by Gopalappa, Ramu, Suresh, Bharathi, Ramakrishna, Suresh, Kim, Hyongbum (Henry)

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Cell-Penetrating Peptide-Mediated Delivery of Cas9 Protein and Guide RNA for Genome Editing by Suresh, Bharathi, Ramakrishna, Suresh, Kim, Hyongbum

“…The clustered, regularly interspaced, short palindromic repeat (CRISPR)-associated (Cas) system represents an efficient tool for genome editing. It consists of…”
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Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity by Ramakrishna, Suresh, Suresh, Bharathi, Bae, Su-Mi, Ahn, Woong-Shick, Lim, Key-Hwan, Baek, Kwang-Hyun

“…We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective…”
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Deubiquitylating enzymes as cancer stem cell therapeutics by Haq, Saba, Suresh, Bharathi, Ramakrishna, Suresh

“…The focus of basic and applied research on core stem cell transcription factors has paved the way to initial delineation of their characteristics, their…”
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Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruption by Gopalappa, Ramu, Suresh, Bharathi, Ramakrishna, Suresh, Kim, Hyongbum (Henry)

“…Abstract The use of paired Cas9 nickases instead of Cas9 nuclease drastically reduces off-target effects. Because both nickases must function for a nickase…”
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The Role of Deubiquitinating Enzymes in Primary Bone Cancer by Colaco, Jencia Carminha, Suresh, Bharathi, Kaushal, Kamini, Singh, Vijai, Ramakrishna, Suresh

“…Bone is a living, intricate, and dynamic tissue providing locomotion and protection of the body. It also performs hematopoiesis and mineral homeostasis…”
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role of deubiquitinating enzymes in apoptosis by Ramakrishna, Suresh, Suresh, Bharathi, Baek, Kwang-Hyun

“…It has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating enzymes (DUBs) have been…”
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Promising bio-composites of polypyrrole and chitosan: Surface protective and in vitro biocompatibility performance on 316L SS implants by Kumar, A. Madhan, Suresh, Bharathi, Das, Soumyadip, Obot, I.B., Adesina, Akeem Yusuf, Ramakrishna, Suresh

“…[Display omitted] •PPy/chitosan coatings were electrochemically deposited on 316L SS implants.•Porous surface morphology was obtained to enrich the…”
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Hybrid nanocomposite coatings from PEDOT and BN-TiO2 nanosheets: Enhanced invitro corrosion resistance, wettability and biocompatibility for biomedical applications by Kumar, A. Madhan, Khan, Abuzar, Hussein, M.A., Khan, Mohd Yusuf, Dafalla, Hatim, Suresh, Bharathi, Ramakrishna, Suresh

“…The aim of this study is to develop the polymer nanocomposite coatings based on conducting polymer and hexagonal boron nitride (BN) nanosheets to improve…”
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