Magneto-luminescent nanocrystalline hydroxyapatite (Gd, Ho: HAp @Cu-NC) for prospective T1-T2 magnetic resonance imaging and fluorescence bioimaging

Magneto-luminescent nanocrystalline hydroxyapatite (Gd, Ho: HAp @Cu-NC) for prospective T1-T2 magnetic resonance imaging and fluorescence bioimaging

Herein, we report luminomagnetic nanocrystalline hydroxyapatite doped with paramagnetic labels and surface modified with luminescent copper nanoclusters. The dopant concentration is obtained through ICP-MS analysis as 4.99% of Gd 3+ and 0.61% of Ho 3+ . Upon excitation at 310 nm, nanocrystals exhibi...

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Bibliographic Details
Published in:Journal of materials research Vol. 38; no. 7; pp. 1963 - 1972
Main Authors: Devi, J. S., Surendran, Dancy, Syamchand, Sasidharanpillai S.
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 14-04-2023
Springer Nature B.V
Subjects:
Applied and Technical Physics
Biomaterials
Chemistry and Materials Science
Contrast agents
Copper
Fluorescence
Gadolinium
Holmium
Hydroxyapatite
Inorganic Chemistry
Magnetic resonance imaging
Magnetic saturation
Materials Engineering
Materials research
Materials Science
Medical imaging
Nanoclusters
Nanocrystals
Nanotechnology
Toxicity
Magneto-luminescent nanocrystals
Fluorescence bioimaging
Bimodal imaging
T1-T2 contrast agents
MRI
Biocompatibility
Hydroxyapatite
Luminomagnetic nanomaterials
Copper nanocluster
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Summary:Herein, we report luminomagnetic nanocrystalline hydroxyapatite doped with paramagnetic labels and surface modified with luminescent copper nanoclusters. The dopant concentration is obtained through ICP-MS analysis as 4.99% of Gd 3+ and 0.61% of Ho 3+ . Upon excitation at 310 nm, nanocrystals exhibit luminescence with emission maxima at 402 nm. The paramagnetic nanocrystals show saturation magnetization of 19.063 emu g −1 . The nanocrystals have potential in developing T1 and T2 bimodal MRI contrast agents due to remarkable longitudinal as well as transverse relaxivities, values of which are 12.25 s −1  mM −1 and 24.76 s −1  mM −1 respectively. The MTT assay and morphological examination on HeLa cells revealed non-toxicity of nanocrystals up to 250 µg/mL for 24 h incubation. It is investigated that nanocrystals are readily taken up by L929 mouse lung fibroblast cells. Said nanocrystals are potentially persuasive nanoprobes for bimodal MRI and fluorescence bioimaging. Graphical abstract
ISSN:0884-2914
2044-5326
DOI:10.1557/s43578-023-00933-x